Radio Nuclide Therapy: From Molecular to Cure

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2373

Special Issue Editor

Special Issue Information

Dear Colleagues,

After the introduction of radioiodine therapy for thyrotoxicosis and differentiated thyroid cancer in the middle of the last century, radionuclide therapy (RNT) underwent an enormous development exploring innovative ways.

Despite this, RNT faces many challenges and limitations:

  • A molecular vector with high affinity and specificity for the tumor target;
  • A nuclide, preferable a true theranostic, with the emission and effective half-life fitting with uptake rate and residence in the target;
  • The chelator and cages;
  • Nanogenerators;
  • Tumor cells kinetics and metabolism;
  • Cell radiobiology;
  • Combined use with chemotherapeutics, biological drugs and EBRT, beta and alpha sequence.

We cordially invite authors in the field to submit original research or review articles pertaining to this important and fast-progressing field of biomedicine.

Dr. Carlo Aprile
Guest Editor

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Keywords

  • alpha emission
  • beta emission
  • radiobiology
  • cancer therapy
  • radiopharmaceutical
  • internal radiotherapy
  • radionuclides
  • theranostic

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Published Papers (1 paper)

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Research

13 pages, 2912 KiB  
Article
Exploring the Potential of Zirconium-89 in Diagnostic Radiopharmaceutical Applications: An Analytical Investigation
by Ahmed M. A. Mostafa, Hesham M. H. Zakaly, Shams A. M. Issa, Mohamed A. M. Uosif, Ziyad A. Alrowaili and Michael V. Zhukovsky
Biomedicines 2023, 11(4), 1173; https://doi.org/10.3390/biomedicines11041173 - 13 Apr 2023
Cited by 1 | Viewed by 1770
Abstract
This study highlights the use of 89Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys, inflammations, and tumors, and [...] Read more.
This study highlights the use of 89Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys, inflammations, and tumors, and analyzes the maximum amount of nuclear transformation per Bq intake for each organ. The retention time of the maximum nuclear transformation and the absorbed doses of the drug in various organs and tissues are also examined. Data from clinical and laboratory studies on radiopharmaceuticals are used to estimate the coefficients of transition. The accumulation and excretion of the radiopharmaceutical in the organs is assumed to follow an exponential law. The coefficients of transition from the organs to the blood and vice versa are estimated using a combination of statistical programs and digitized data from the literature. WinAct and IDAC 2.1 software are used to calculate the distribution of the radiopharmaceutical in the human body and to estimate the absorbed doses in organs and tissues. The results of this study can provide valuable information for the biokinetic modeling of wide-spectrum diagnostic radiopharmaceuticals. The results show that 89Zr-oxalate has a high affinity for bones and a relatively low impact on healthy organs, making it helpful in targeting bone metastases. This study provides valuable information for further research on the development of this drug for potential clinical applications. Full article
(This article belongs to the Special Issue Radio Nuclide Therapy: From Molecular to Cure)
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