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Biomedicines
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Microbiota Implication in Endocrine-Related Diseases: From Development to Novel Therapeutic...
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Microbiota Implication in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 10557

Special Issue Editors

Dr. Serena Martinelli

E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy
Interests: oncology; metastasis; cell cultures; 3D models; cancer organoids; microbiota
Special Issues, Collections and Topics in MDPI journals
Dr. Giulia Nannini

E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy
Interests: immune system; cell cultures; microbiota; colorectal cancer; inflammatory diseases

Special Issue Information

Dear Colleagues,

Human microbiota, made up of trillions of microorganisms that reside in our bodies, has emerged as a key player in the development and progression of various diseases, including endocrine disorders. By comprehensively examining the interaction between microbiota and the endocrine system, this Special Issue wishes to elucidate the mechanisms by which microbiota disbiosis may contribute to the onset and progression of endocrine-related disease, with the ultimate aim of providing valuable insights into directions of future research and clinical interventions in this exciting field.

Dr. Serena Martinelli
Dr. Giulia Nannini
Guest Editors

Manuscript Submission Information

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Keywords

  • microbiota
  • endocrine-related cancers
  • hormones
  • endocrine pathology

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Published Papers (4 papers)

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Research

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27 pages, 39769 KiB  
Article
Uterine Commensal Peptostreptococcus Species Contribute to IDO1 Induction in Endometrial Cancer via Indoleacrylic Acid
by Qiong Wang, Yaqiong Liu, Weiwei Chen, Sha Chen, Minting Su, Yanqin Zheng, Wenjie Liu, Li Li, Liang Zeng, Quan Shi, Juan He, Yuanmin Qian, Xingcui Xuan, Qirong Wen, Gendie E. Lash and Kun Shi
Biomedicines 2024, 12(3), 573; https://doi.org/10.3390/biomedicines12030573 - 4 Mar 2024
Cited by 1 | Viewed by 1654
Abstract
Microbial dysbiosis has an increasingly appreciated impact on carcinogenesis, and the cervicovaginal microbiome plays a critical role in microenvironmental inflammation. Here, we investigated the involvement of the female genital tract Peptostreptococcus species in gynecological cancer via indoleacrylic acid (IAA). IAA production from Peptostreptococcus [...] Read more.
Microbial dysbiosis has an increasingly appreciated impact on carcinogenesis, and the cervicovaginal microbiome plays a critical role in microenvironmental inflammation. Here, we investigated the involvement of the female genital tract Peptostreptococcus species in gynecological cancer via indoleacrylic acid (IAA). IAA production from Peptostreptococcus species and the effect of bacterial culture on tumor growth in vivo were examined. The impact of IAA on cytokine production and indoleamine-2,3-dioxygenase 1 (IDO1) expression in an endometrial cancer (EC) cell line, as well as their effect on Treg and Teff cells, and M1 and M2 macrophage populations were examined in EC patients and tumor-grafted mice. Clinically, Peptostreptococcus species abundance, IAA, and IDO1 expression were verified in EC patients. The results showed that IAA production was induced in the uteri of BALB/c nude mice by Peptostreptococcus species transplantation, and the intratumoral injection of a conditioned medium from Peptostreptococcus cultures into tumor-grafted mice promoted tumor growth. IL-10 expression was upregulated by IAA; IFN-γ expression was increased by IL-10. IFN-γ induced IDO1 expression in the EC cell line. The co-culture of IDO1-expressing EC cells with peripheral blood mononuclear cells upregulated the Treg proportion and decreased the M1/M2 ratio. Clinically, P. anaerobius was more abundant amongst the uterine microbiota of EC patients than the control. The IAA, IDO1, and kynurenine/tryptophan ratios were all higher in EC tissue, and the M1/M2 ratio was lower. Our study sheds light on the link between IDO1 induction and uterine Peptostreptococcus dysbiosis and provides a potential rationale for the role of Peptostreptococcus species in immune tolerance induction in type I endometrial cancer. Full article
(This article belongs to the Special Issue Microbiota Implication in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches)
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16 pages, 1549 KiB  
Article
Maternal Exposure to Endocrine-Disrupting Chemicals: Analysis of Their Impact on Infant Gut Microbiota Composition
by Mirco Vacca, Francesco Maria Calabrese, Federica Loperfido, Beatrice Maccarini, Rosa Maria Cerbo, Eduardo Sommella, Emanuela Salviati, Luana Voto, Maria De Angelis, Gabriele Ceccarelli, Ilaria Di Napoli, Benedetta Raspini, Debora Porri, Elisa Civardi, Francesca Garofoli, Pietro Campiglia, Hellas Cena and Rachele De Giuseppe
Biomedicines 2024, 12(1), 234; https://doi.org/10.3390/biomedicines12010234 - 19 Jan 2024
Cited by 4 | Viewed by 1939
Abstract
Endocrine disruptors (EDCs) are chemicals that interfere with the endocrine system. EDC exposure may contribute to the development of obesity, type 2 diabetes, and cardiovascular diseases by impacting the composition of an infant’s gut microbiota during the first 1000 days of life. To [...] Read more.
Endocrine disruptors (EDCs) are chemicals that interfere with the endocrine system. EDC exposure may contribute to the development of obesity, type 2 diabetes, and cardiovascular diseases by impacting the composition of an infant’s gut microbiota during the first 1000 days of life. To explore the relationship between maternal urinary levels of Bisphenol-A and phthalates (UHPLC-MS/MS), and the composition of the infant gut microbiota (16S rDNA) at age 12 months (T3) and, retrospectively, at birth (T0), 1 month (T1), and 6 months (T2), stool samples from 20 infants breastfed at least once a day were analyzed. Metataxonomic bacteria relative abundances were correlated with EDC values. Based on median Bisphenol-A levels, infants were assigned to the over-exposed group (O, n = 8) and the low-exposed group (B, n = 12). The B-group exhibited higher gut colonization of the Ruminococcus torques group genus and the O-group showed higher abundances of Erysipelatoclostridium and Bifidobacterium breve. Additionally, infants were stratified as high-risk (HR, n = 12) or low-risk (LR, n = 8) exposure to phthalates, based on the presence of at least three phthalates with concentrations exceeding the cohort median values; no differences were observed in gut microbiota composition. A retrospective analysis of gut microbiota (T0–T2) revealed a disparity in β-diversity between the O-group and the B-group. Considering T0–T3, the Linear Discriminant Effect Size indicated differences in certain microbes between the O-group vs. the B-group and the HR-group vs. the LR-group. Our findings support the potential role of microbial communities as biomarkers for high EDC exposure levels. Nevertheless, further investigations are required to deeply investigate this issue. Full article
(This article belongs to the Special Issue Microbiota Implication in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches)
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Review

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42 pages, 1995 KiB  
Review
Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies
by Giada Marroncini, Laura Naldi, Serena Martinelli and Amedeo Amedei
Biomedicines 2024, 12(7), 1398; https://doi.org/10.3390/biomedicines12071398 - 24 Jun 2024
Cited by 3 | Viewed by 2321
Abstract
The functions of the gut are closely related to those of many other organs in the human body. Indeed, the gut microbiota (GM) metabolize several nutrients and compounds that, once released in the bloodstream, can reach distant organs, thus influencing the metabolic and [...] Read more.
The functions of the gut are closely related to those of many other organs in the human body. Indeed, the gut microbiota (GM) metabolize several nutrients and compounds that, once released in the bloodstream, can reach distant organs, thus influencing the metabolic and inflammatory tone of the host. The main microbiota-derived metabolites responsible for the modulation of endocrine responses are short-chain fatty acids (SCFAs), bile acids and glucagon-like peptide 1 (GLP-1). These molecules can (i) regulate the pancreatic hormones (insulin and glucagon), (ii) increase glycogen synthesis in the liver, and (iii) boost energy expenditure, especially in skeletal muscles and brown adipose tissue. In other words, they are critical in maintaining glucose and lipid homeostasis. In GM dysbiosis, the imbalance of microbiota-related products can affect the proper endocrine and metabolic functions, including those related to the gut–liver–pancreas axis (GLPA). In addition, the dysbiosis can contribute to the onset of some diseases such as non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), and type 2 diabetes (T2D). In this review, we explored the roles of the gut microbiota-derived metabolites and their involvement in onset and progression of these diseases. In addition, we detailed the main microbiota-modulating strategies that could improve the diseases’ development by restoring the healthy balance of the GLPA. Full article
(This article belongs to the Special Issue Microbiota Implication in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches)
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42 pages, 1151 KiB  
Review
Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches
by Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Alejandro Rubio-Zarapuz, Alexandra Martín-Rodríguez and José Francisco Tornero-Aguilera
Biomedicines 2024, 12(1), 221; https://doi.org/10.3390/biomedicines12010221 - 18 Jan 2024
Cited by 4 | Viewed by 3623
Abstract
This comprehensive review article delves into the critical role of the human microbiota in the development and management of endocrine-related diseases. We explore the complex interactions between the microbiota and the endocrine system, emphasizing the implications of microbiota dysbiosis for the onset and [...] Read more.
This comprehensive review article delves into the critical role of the human microbiota in the development and management of endocrine-related diseases. We explore the complex interactions between the microbiota and the endocrine system, emphasizing the implications of microbiota dysbiosis for the onset and progression of various endocrine disorders. The review aims to synthesize current knowledge, highlighting recent advancements and the potential of novel therapeutic approaches targeting microbiota-endocrine interactions. Key topics include the impact of microbiota on hormone regulation, its role in endocrine pathologies, and the promising avenues of microbiota modulation through diet, probiotics, prebiotics, and fecal microbiota transplantation. We underscore the importance of this research in advancing personalized medicine, offering insights for more tailored and effective treatments for endocrine-related diseases. Full article
(This article belongs to the Special Issue Microbiota Implication in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches)
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