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Biomedicines
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Diagnosis and Treatment of Skin Diseases in Light of Molecular...
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Diagnosis and Treatment of Skin Diseases in Light of Molecular Medicine

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 12956

Special Issue Editor

Dr. Olga Simionescu

E-Mail Website
Guest Editor
Chief of the First Clinic of Dermatology, Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, Colentina Hospital, 020125 Bucharest, Romania
Interests: skin cancer; dermoscopy; melanom; psoriasis; connective tissue diseases; venereology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dermatology is an ongoing field, with more and more precise reclassifications. This tremendous progress has a solid foundation: a greater understanding of molecular mechanisms. Nowadays, diagnostic methods have gained accuracy and enable rapid global interconnection between individuals within different continents. Targeting molecules in psoriasis, atopic dermatitis, and melanoma opens the door toward an immunological approach to the skin, an amazing immune organ. The escape mechanisms of sexually transmitted disease pathogens or detailed characterizations of herpetic viruses (e.g., Epstein–Barr as number four, CMV as number five) are topics of interest that move forward in this field.

We look forward to receiving original papers and literature reviews that use molecular medicine and clinical experience.

Dr. Olga Simionescu
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermoscopy
  • psoriasis
  • skin cancer
  • melanoma
  • BCC
  • SCC
  • cytokines
  • IHC
  • biologics

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Published Papers (4 papers)

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Research

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10 pages, 2564 KiB  
Article
Immunohistochemical Analysis of Single-Stranded DNA Binding Protein 2 in Non-Melanoma Skin Cancers
by Seongsik Bang, Hwangkyu Son, Hyebin Cha, Kihyuk Song, Hosub Park, Hyunsung Kim, Joo Yeon Ko, Jaekyung Myung and Seungsam Paik
Biomedicines 2023, 11(7), 1818; https://doi.org/10.3390/biomedicines11071818 - 25 Jun 2023
Viewed by 1267
Abstract
Single-stranded DNA binding protein 2 (SSBP2) is a tumor suppressor candidate. In this study, the expression level and clinicopathological significance of SSBP2 in squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were evaluated. We also identified biological pathways associated with a set [...] Read more.
Single-stranded DNA binding protein 2 (SSBP2) is a tumor suppressor candidate. In this study, the expression level and clinicopathological significance of SSBP2 in squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were evaluated. We also identified biological pathways associated with a set of genes potentially related to SSBP2. Immunohistochemistry (IHC) was performed on 70 SCC and 146 BCC cases to assess SSBP2 expression semi-quantitatively. In addition, the associations between SSBP2 expression and clinicopathological characteristics were analyzed. Gene ontology (GO) enrichment analysis was performed using publicly available data and web-based bioinformatics tools. Compared with BCC, SCC had a significantly low SSBP2 expression (p < 0.001). In total, 12 (17.1%) of the 70 SCC cases and 30 (20.5%) of the 146 BCC cases showed low SSBP2 expression. Among SCC cases, ulceration (p = 0.005) and a deep level of invasion (p = 0.012) showed an association with low SSBP2 expression. Local recurrence was slightly more common in the SCC subgroup with low SSBP2 expression, although the difference was not significant (p = 0.058). Using GO enrichment analysis, we identified several biological functions performed by a set of 36 genes in SCC. SSBP2 evaluation using IHC can be helpful in the differential diagnosis of SCC and BCC. SSBP2 expression was associated with tumor invasiveness in SCC. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Skin Diseases in Light of Molecular Medicine)
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Review

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18 pages, 14717 KiB  
Review
Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action
by Denisa Vladulescu, Lucian G. Scurtu, Anca Angela Simionescu, Francesca Scurtu, Marco I. Popescu and Olga Simionescu
Biomedicines 2024, 12(1), 7; https://doi.org/10.3390/biomedicines12010007 - 19 Dec 2023
Cited by 8 | Viewed by 7421
Abstract
Platelet-rich plasma (PRP) therapy has gained attention in the scientific field due to its potential regenerative effects and great benefit–risk ratio. This review extensively explores the most studied mechanisms of this therapy according to the etiopathogenesis of skin diseases: cellular proliferation, matrix formation, [...] Read more.
Platelet-rich plasma (PRP) therapy has gained attention in the scientific field due to its potential regenerative effects and great benefit–risk ratio. This review extensively explores the most studied mechanisms of this therapy according to the etiopathogenesis of skin diseases: cellular proliferation, matrix formation, regulation of inflammation, angiogenesis, collagen synthesis, and the remodeling of new tissue. Moreover, it draws on newly reported and lesser-known effects of PRP: its anti-apoptotic effects, immunological suppression, decrease in melanin synthesis, anti-microbial effects, overexpression of miR-155, antioxidant effects, and their involved pathways. This work aims to provide a complete update for understanding PRP’s benefits and clinical relevance in wound healing, alopecia, pigmentary disorders, scars, rejuvenation, lichen sclerosus, and other inflammatory dermatoses, based on the current evidence. Furthermore, recent reports with novel indications for PRP therapy are highlighted, and new potential pathways correlated with the pathogenesis of skin diseases are explored. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Skin Diseases in Light of Molecular Medicine)
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15 pages, 1469 KiB  
Review
Photodynamic Therapy in Pigmented Basal Cell Carcinoma—A Review
by Ewelina Mazur, Dominika Kwiatkowska and Adam Reich
Biomedicines 2023, 11(11), 3099; https://doi.org/10.3390/biomedicines11113099 - 20 Nov 2023
Cited by 2 | Viewed by 1336
Abstract
This review summarizes the effectiveness of photodynamic therapy (PDT) in the treatment of the pigmented subtype of basal cell carcinoma (BCC) based on the current literature. PDT is a light-activated treatment, non-invasive, that selectively destroys tumor cells and tissues via the interaction of [...] Read more.
This review summarizes the effectiveness of photodynamic therapy (PDT) in the treatment of the pigmented subtype of basal cell carcinoma (BCC) based on the current literature. PDT is a light-activated treatment, non-invasive, that selectively destroys tumor cells and tissues via the interaction of a photosensitizer, light, and molecular oxygen. It can induce cancer cell death through direct tumor vascular damage or via the induction of immune response. However, human skin is also an absorption and scattering medium since it contains hemoglobin and melanin that act as chromophores. Eumelanin can be considered a light-absorber and an intracellular antioxidant that can neutralize PDT-induced ROS and, therefore, decrease PDT success. Various factors, including tumor depth, the degree of pigmentation in malignant cells, and the individual’s skin phototype, can impact the outcome of this intricate biochemical process. It has been widely recognized that PDT exhibits limited efficacy in the treatment of pigmented lesions. However, new combination techniques such as curettage or debulking before PDT show promising results in the treatment of pigmented BCC. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Skin Diseases in Light of Molecular Medicine)
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Other

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33 pages, 8166 KiB  
Systematic Review
Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis
by Dóra Plázár, Fanni Adél Meznerics, Sára Pálla, Pálma Anker, Klára Farkas, András Bánvölgyi, Norbert Kiss and Márta Medvecz
Biomedicines 2023, 11(10), 2717; https://doi.org/10.3390/biomedicines11102717 - 6 Oct 2023
Cited by 2 | Viewed by 2155
Abstract
(1) Background: Genodermatoses are a clinically and genetically heterogenous group of inherited skin disorders. Diagnosing inherited skin diseases is a challenging task due to their rarity and diversity. Dermoscopy is a non-invasive, easily accessible, and rapid tool used in dermatology not only for [...] Read more.
(1) Background: Genodermatoses are a clinically and genetically heterogenous group of inherited skin disorders. Diagnosing inherited skin diseases is a challenging task due to their rarity and diversity. Dermoscopy is a non-invasive, easily accessible, and rapid tool used in dermatology not only for diagnostic processes but also for monitoring therapeutic responses. Standardized terminologies have been published for its proper use, reproducibility, and comparability of dermoscopic terms. (2) Methods: Here, we aimed to investigate dermoscopic features in various genodermatoses by conducting a systematic review and comparing its results to our own findings, data of patients diagnosed with genodermatoses at the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University. (3) Results: Our systematic search provided a total of 471 articles, of which 83 reported both descriptive and metaphoric dermoscopic terminologies of 14 genodermatoses. The literature data were then compared to the data of 119 patients with 14 genodermatoses diagnosed in our department. (4) Conclusion: Dermoscopy is a valuable tool in the diagnosis of genodermatoses, especially when symptoms are mild. To enable the use of dermoscopy as an auxiliary diagnostic method, existing standardized terminologies should be extended to more genodermatoses. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Skin Diseases in Light of Molecular Medicine)
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