Molecular Mechanisms of Steroid Hormone Action—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2328

Special Issue Editor


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Guest Editor
1. Chair of Active Ageing, University of Valencia, 46010 Valencia, Spain
2. Frailty and Cognitive Impairment—FROG Research Group, University of Valencia, 46010 Valencia, Spain
Interests: cognitive impairment; frailty syndrome; neurodevelopemntal disorders; depression; neuropathy; sleep; envirnomental factors; comorbidty; immune alterations; metabolic alterations; biomarkers
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Special Issue Information

Dear Colleague,

Steroid hormones are a versatile and structurally diverse class of molecules. They exert their effects as hormones, as cellular building material, and as signaling molecules in multiple processes. Recent studies have shown that steroids have pleiotropic effects and previously unknown physiological functions. They are involved in disease pathophysiology and play a pivotal role in inflammatory processes. Steroid-based therapy is frequently used in the treatment of several disorders, such as endocrine disorders, auto-immune diseases, inflammatory disorders, and cancer. Consolidated pharmacological approaches, as well as new clinical indications, are emerging for steroid-based therapy, and basic studies on their new mechanisms of action are warranted. This Special Issue is devoted to providing an update on research into steroid actions in the body and steroid-based therapy, from molecular perspectives to preclinical and clinical studies.

Dr. Omar Cauli
Guest Editor

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Keywords

  • oestrogen
  • androgens
  • thyroid
  • adrenal gland
  • menopause
  • cancer

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Published Papers (1 paper)

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23 pages, 1415 KiB  
Review
Molecular, Pathophysiological, and Clinical Aspects of Corticosteroid-Induced Neuropsychiatric Effects: From Bench to Bedside
by Sara Sofía-Avendaño-Lopez, Angela Johanna Rodríguez-Marín, Mateo Lara-Castillo, Juanita Agresott-Carrillo, Luna Estefanía Lara-Cortés, Juan Felipe Sánchez-Almanzar, Sophya Villamil-Cruz, Luis Carlos Rojas-Rodríguez, Daniel Felipe Ariza-Salamanca, Mariana Gaviria-Carrillo, Carlos Alberto Calderon-Ospina and Jesús Rodríguez-Quintana
Biomedicines 2024, 12(9), 2131; https://doi.org/10.3390/biomedicines12092131 - 19 Sep 2024
Viewed by 1622
Abstract
Corticosteroids are frequently prescribed across medical disciplines, yet they are associated with various adverse effects, including neuropsychiatric symptoms, documented since their introduction over 60 years ago. The cellular mechanisms underlying neuropsychiatric symptoms are complex and somewhat obscure, involving multiple pathways. Notably, they include [...] Read more.
Corticosteroids are frequently prescribed across medical disciplines, yet they are associated with various adverse effects, including neuropsychiatric symptoms, documented since their introduction over 60 years ago. The cellular mechanisms underlying neuropsychiatric symptoms are complex and somewhat obscure, involving multiple pathways. Notably, they include changes in excitability, cellular death of hippocampal and striatal neurons, and increased inflammation and oxidative stress. Clinical presentation varies, encompassing affective disorders (anxiety, euphoria, depression), psychotic episodes, and cognitive deficits. It is crucial to note that these manifestations often go unnoticed by treating physicians, leading to delayed detection of severe symptoms, complications, and underreporting. Discontinuation of corticosteroids constitutes the cornerstone of treatment, resolving symptoms in up to 80% of cases. Although the literature on this topic is scant, isolated cases and limited studies have explored the efficacy of psychotropic medications for symptomatic control and prophylaxis. Pharmacological intervention may be warranted in situations where corticosteroid reduction or withdrawal is not feasible or beneficial for the patient. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Steroid Hormone Action—2nd Edition)
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