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Biomedicines
Special Issues
Recent Advances in Arthritis and Tendinopathy
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Recent Advances in Arthritis and Tendinopathy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 9058

Special Issue Editors

Dr. Po-Ting Wu

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Guest Editor
Department of Orthopaedics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan
Interests: arthritis; tendinopathy; orthopedic surgery; ultrasound-related musculoskeletal research; arthritis
Dr. Chung-Hwan Chen

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Guest Editor
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan
Interests: osteoporosis; bone and cartilage; EGCG catechin; osteoarthritis; stem cell; development/degeneration of spine
Special Issues, Collections and Topics in MDPI journals
Dr. Tulyapruek Tawonsawatruk

E-Mail Website
Guest Editor
Department of Orthopaedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
Interests: orthobiologics; tendinopathy; tissue engineering; mesenchymal stem cells

Special Issue Information

Dear Colleagues,

Arthritis and tendinopathy are two of the most common musculoskeletal disorders. However, current clinical treatment strategies cannot yield satisfactory results. Recently, an increasing number of biomarkers, microRNAs, lncRNAs, and cellular responses have been proposed to be involved in pathogenesis and would be therapeutic candidates in addition to stem cells, exosomes, biomaterials, and nanomaterials. Reducing inflammation, apoptosis, or senescence, enhancing M2 macrophage polarization, and maintaining extracellular matrix homeostasis in cartilage or tendons are common therapeutic approaches. Therefore, the Special Issue aims to highlight “diagnosis” and “treatment” of arthritis and tendinopathy. Articles presenting new strategies supported by experimental or clinical results and comprehensive evidence-based reviews are welcome. This issue will provide new insight into pathogenesis and treatment of arthritis and tendinopathy.

Dr. Po-Ting Wu
Dr. Chung-Hwan Chen
Dr. Tulyapruek Tawonsawatruk
Guest Editors

Manuscript Submission Information

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Keywords

  • arthritis
  • tendinopathy
  • inflammation
  • diagnosis
  • treatment
  • pathogenesis
  • orthobiologics

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Published Papers (5 papers)

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Research

17 pages, 1349 KiB  
Article
Evaluation of Patellar Tendon Structural Changes following Biological Treatments: Secondary Analysis of Double-Blinded Clinical Trial of Bone Marrow Mesenchymal Stromal Cells and Leukocyte-Poor Platelet-Rich Plasma
by Silvia Ortega-Cebrián, Robert Soler-Rich, Lluis Orozco and Gil Rodas
Biomedicines 2024, 12(7), 1599; https://doi.org/10.3390/biomedicines12071599 - 18 Jul 2024
Viewed by 909
Abstract
Objective quantification of tendon structural changes through imaging is only achieved by evaluating tendon structure using ultrasound tissue characterization (UTC) technology. This study compares the effects of bone marrow mesenchymal stromal cells (BM-MSC) and leukocyte-poor platelet-rich plasma (Lp-PRP) on tendon structure and clinical [...] Read more.
Objective quantification of tendon structural changes through imaging is only achieved by evaluating tendon structure using ultrasound tissue characterization (UTC) technology. This study compares the effects of bone marrow mesenchymal stromal cells (BM-MSC) and leukocyte-poor platelet-rich plasma (Lp-PRP) on tendon structure and clinical outcomes in male patients with patellar tendinopathy measured with UTC at 3, 6, and 12 months after treatment. This is a double-blinded clinical trial with a randomized active control study with 20 male patients diagnosed with patellar tendinopathy who underwent BM-MSC and Lp-PRP. Bilateral ultrasound tissue characterization scans of the patellar tendon were carried out after 3, 6, and 12 months, as well as tests for strength and pain. UTC patellar tendon was analyzed at the insertion, proximal, and mid-tendon. BM-MSC showed a greater capacity to promote further positive changes than Lp-PRP. Lp-PRP presented higher disorganized echo-type II in the mid-tendon (p = 0.04; ES = 1.06) and III (p = 0.02; ES = −1.47) after 3 months in the Lp-PRP group. Similar results were seen after 6 and 12 months. Pain and strength data show improvement in the treated tendon. BM-MSC treatment demonstrates a superior capacity to promote tendon regeneration and organization, restore strength, and reduce pain compared to Lp-PRP, after 3, 6, and 12 months in male patients with patellar tendinopathy. Full article
(This article belongs to the Special Issue Recent Advances in Arthritis and Tendinopathy)
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15 pages, 3888 KiB  
Article
Cellular and Structural Changes in Achilles and Patellar Tendinopathies: A Pilot In Vivo Study
by Dimitrios Kouroupis, Carlotta Perucca Orfei, Diego Correa, Giuseppe Talò, Francesca Libonati, Paola De Luca, Vincenzo Raffo, Thomas M. Best and Laura de Girolamo
Biomedicines 2024, 12(5), 995; https://doi.org/10.3390/biomedicines12050995 - 30 Apr 2024
Viewed by 1347
Abstract
Tendinopathies continue to be a challenge for both patients and the medical teams providing care as no universal clinical practice guidelines have been established. In general, tendinopathies are typically characterized by prolonged, localized, activity-related pain with abnormalities in tissue composition, cellularity, and microstructure [...] Read more.
Tendinopathies continue to be a challenge for both patients and the medical teams providing care as no universal clinical practice guidelines have been established. In general, tendinopathies are typically characterized by prolonged, localized, activity-related pain with abnormalities in tissue composition, cellularity, and microstructure that may be observed on imaging or histology. In the lower limb, tendinopathies affecting the Achilles and the patellar tendons are the most common, showing a high incidence in athletic populations. Consistent diagnosis and management have been challenged by a lack of universal consensus on the pathophysiology and clinical presentation. Current management is primarily based on symptom relief and often consists of medications such as non-steroidal anti-inflammatories, injectable therapies, and exercise regimens that typically emphasize progressive eccentric loading of the affected structures. Implementing the knowledge of tendon stem/progenitor cells (TSPCs) and assessing their potential in enhancing tendon repair could fill an important gap in this regard. In the present pilot in vivo study, we have characterized the structural and cellular alterations that occur soon after tendon insult in models of both Achilles and patellar tendinopathy. Upon injury, CD146+ TSPCs are recruited from the interfascicular tendon matrix to the vicinity of the paratenon, whereas the observed reduction in M1 macrophage polarization is related to a greater abundance of reparative CD146+ TSPCs in situ. The robust TSPCs’ immunomodulatory effects on macrophages were also demonstrated in in vitro settings where TSPCs can effectively polarize M1 macrophages towards an anti-inflammatory therapeutic M2 phenotype. Although preliminary, our findings suggest CD146+ TSPCs as a key phenotype that could be explored in the development of targeted regenerative therapies for tendinopathies. Full article
(This article belongs to the Special Issue Recent Advances in Arthritis and Tendinopathy)
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Graphical abstract

13 pages, 1698 KiB  
Article
Evaluating the Diagnostic Performance of Systemic Immune-Inflammation Index in Childhood Inflammatory Arthritis: A Focus on Differentiating Juvenile Idiopathic Arthritis from Reactive Arthritis
by Delia-Maria Nicoară, Andrei-Ioan Munteanu, Alexandra-Cristina Scutca, Giorgiana-Flavia Brad, Raluca Asproniu, Iulius Jugănaru and Otilia Mărginean
Biomedicines 2024, 12(1), 65; https://doi.org/10.3390/biomedicines12010065 - 27 Dec 2023
Cited by 1 | Viewed by 1640
Abstract
In pediatric care, the range of potential diagnoses for arthritis can be relatively extensive, primarily involving infectious and inflammatory causes and, to a lesser extent, oncological conditions. Specifically, when addressing inflammatory causes, differentiating between Juvenile Idiopathic Arthritis (JIA) and Reactive Arthritis (ReA) can [...] Read more.
In pediatric care, the range of potential diagnoses for arthritis can be relatively extensive, primarily involving infectious and inflammatory causes and, to a lesser extent, oncological conditions. Specifically, when addressing inflammatory causes, differentiating between Juvenile Idiopathic Arthritis (JIA) and Reactive Arthritis (ReA) can prove to be challenging during the first weeks, owing to the lack of specific antibodies in several JIA subtypes. This single-center retrospective study of 108 children with arthritis aimed to evaluate in greater detail the complete blood count (CBC) profiles of children with JIA and ReA in greater detail. The most significant differences were noted in terms of the Systemic Immune-Inflammation Index (SII), with higher values in the JIA group. Moreover, within the JIA group, SII displayed a significant positive correlation with conventional inflammatory biomarkers, specifically C-reactive protein (ρ = 0.579) and Erythrocyte Sedimentation Rate (ρ = 0.430). It was the only independent factor associated with the presence of JIA after adjusting for age (p = 0.030). Also, even with the moderate diagnostic value, the discriminating capacity of SII was superior to those of each of its component CBC parameters according to receiver operating characteristic (ROC) analysis. In summary, this study identified elevated SII values in the JIA group compared to the ReA group, indicating the potential utility of SII as an adjuvant discriminatory marker between these two arthritis forms. Full article
(This article belongs to the Special Issue Recent Advances in Arthritis and Tendinopathy)
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11 pages, 1661 KiB  
Article
Determining the Most Suitable Ultrasound-Guided Injection Technique in Treating Lumbar Facet Joint Syndrome
by Areerat Suputtitada, Jean-Lon Chen, Chih-Kuan Wu, Yu-Ning Peng, Tzu-Yun Yen and Carl P. C. Chen
Biomedicines 2023, 11(12), 3308; https://doi.org/10.3390/biomedicines11123308 - 14 Dec 2023
Cited by 1 | Viewed by 2819
Abstract
(1) Background: Lower back pain is often caused by lumbar facet joint syndrome. This study investigated the effectiveness of three different injection methods under ultrasound guidance in treating elderly patients with lumbar facet joint syndrome. The difficulty in performing these injections was also [...] Read more.
(1) Background: Lower back pain is often caused by lumbar facet joint syndrome. This study investigated the effectiveness of three different injection methods under ultrasound guidance in treating elderly patients with lumbar facet joint syndrome. The difficulty in performing these injections was also evaluated; (2) Methods: A total of 60 elderly patients with facet joint syndrome as the cause of lower back pain were recruited and divided into 3 groups. Group 1 received medial branch block (MBB). Group 2 received intra-articular facet joint injections. Group 3 received injection into the multifidus muscle portion that covers the facet joint. Five percent dextrose water (D5W) was used as the injectant. The visual analog scale (VAS) was used to measure the degree of lower back pain; (3) Results: Before the injection treatments, the VAS score averaged about 7.5. After three consecutive injection treatments (two weeks interval), the VAS score decreased significantly to an average of about 1 in all 3 groups, representing mild to no pain. Between group analyses also did not reveal significant statistical differences, suggesting that these procedures are equally effective; (4) Conclusions: Ultrasound-guided injection of the multifidus muscle may be a feasible option in treating elderly patients with lower back pain caused by facet joint syndrome as it is easier to perform as compared to MBB and intra-articular facet joint injection. Full article
(This article belongs to the Special Issue Recent Advances in Arthritis and Tendinopathy)
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10 pages, 1347 KiB  
Article
Weight Is a Predictor of Delayed Operation Time in Primary Isolated Anterior Cruciate Ligament Reconstruction
by Sungtae Lim, Sung-Sahn Lee, Juyong Oh and Dae-Hee Lee
Biomedicines 2023, 11(8), 2137; https://doi.org/10.3390/biomedicines11082137 - 29 Jul 2023
Cited by 1 | Viewed by 1395
Abstract
Background: Few studies have evaluated the impact of obesity on operation time in patients with ACL reconstruction. The purpose of this study was to understand the effect of obesity on operation time in patients with arthroscopic anterior cruciate ligament (ACL) reconstruction. Methods: A [...] Read more.
Background: Few studies have evaluated the impact of obesity on operation time in patients with ACL reconstruction. The purpose of this study was to understand the effect of obesity on operation time in patients with arthroscopic anterior cruciate ligament (ACL) reconstruction. Methods: A total of 103 patients were included. The mean pure operation time was 45.9 ± 13.4 min. Considering that 15 min incremental increases in operation time are an independent risk factor for complications, all patients were classified into two groups according to operation time: more or less than 61 min. Demographic data were compared between both groups. Pure operation time was defined as operative time without suture time (pure operation time = suture start time − operation start time). Correlation analysis between demographic data and pure operation time was performed, and multiple linear regression analysis was used to identify the predictors of pure operation time. Results: The pure operation time ≥61 min group (n = 34) had a 14.7 kg higher weight and 4.5 kg/m2 higher body mass index (BMI) than those with pure operation time < 61 min (n = 69). Weight (r = 0.635, p < 0.001) and BMI (r = 0.584, p < 0.001) were positively correlated with operation time. Multiple linear regression analysis showed that weight (β = 0.635, p < 0.001) was the only predictor of operation time. A weight of 74.25 kg was a cut-off value for a pure operation time of >61 min. Conclusions: The weight and BMI of the group with pure operation time of ≥61 min were 14.7 kg and 4.5 kg/m2 higher, respectively. The weight of patients with ACL tears was a factor affecting delay in the operation time. Patients weighing over 74.25 kg were more likely to delay ACL reconstruction. Full article
(This article belongs to the Special Issue Recent Advances in Arthritis and Tendinopathy)
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