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Biomedicines
Special Issues
Editorial Board Members' Collection Series: Immunotherapy
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Editorial Board Members' Collection Series: Immunotherapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 2244

Special Issue Editors

Dr. Juan Gambini

E-Mail Website
Guest Editor
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, E46010 Valencia, Spain
Interests: diet; oxidative stress; longevity; aging; polyphenols
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lucio Pastore

E-Mail Website
Guest Editor
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131 Naples, Italy
Interests: gene therapy; cancer gene therapy; immunotherapy; immunovirotherapy; adenovirus; helper-dependent adenoviral vectors; liver directed gene therapy; inborn errors of metabolism; stem cell biology; regenerative medicine
Dr. Gabriele Di Lorenzo

E-Mail Website
Guest Editor
Department of Health Promotion Science and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy
Interests: allergic diseases; immunotherapy; internal medicine

Special Issue Information

Dear Colleagues,

We are pleased to announce a new Collection entitled “Editorial Board Members' Collection Series: Immunotherapy”, which will collect papers invited by the Editorial Board Members.

The aim of this Collection is to provide a venue for networking and communication between Biomedicines and scholars in the field of immunotherapy. All papers will be published in open-access format following peer review.

Prof. Dr. Juan Gambini
Prof. Dr. Lucio Pastore
Dr. Gabriele Di Lorenzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunology
  • immunotherapy
  • lymphocytes
  • macrophages
  • eosinophils
  • neutrophils

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

13 pages, 1132 KiB  
Article
Vitamin D Role in Childhood Mite Allergy and Allergen Immunotherapy (AIT)
by Claudia Petrarca and Davide Viola
Biomedicines 2023, 11(6), 1700; https://doi.org/10.3390/biomedicines11061700 - 13 Jun 2023
Cited by 1 | Viewed by 1503
Abstract
The post hoc analysis presented here aimed to address the influence of endogenous vitamin D in the immunological mechanism underlying effective mite allergoid immunotherapy (AIT). Previously, we have shown that in allergic children, after 12 months of this immunoactive treatment, functionally potentiated memory [...] Read more.
The post hoc analysis presented here aimed to address the influence of endogenous vitamin D in the immunological mechanism underlying effective mite allergoid immunotherapy (AIT). Previously, we have shown that in allergic children, after 12 months of this immunoactive treatment, functionally potentiated memory regulatory T cells are identified. Indeed, AIT is the only known treatment that is able to reshape the detrimental immune response against the allergen into a non-noxious one. Besides, VD is widely considered an immunoregulatory molecule that is endogenously produced and exogenously provided by foods and supplements that might interact with the AIT mechanism, thus affecting its outcome. Therefore, a post hoc analysis of the clinical and immunological data from three different cohorts of allergic patients was performed. One cohort (N = 70) was on a standard symptom-controlling pharmacological treatment, while the other two (N = 60 and N = 35) were treated with AIT for 12 months. In the first cohort, a lower mean endogenous VD level (<22 ng/mL) was observed along with worse symptoms and a greater use of medications. Remarkably, the comparison between two sub-cohorts of patients with a serum VD level above (N = 32) or below (N = 28) a cut-off value set at the mean value (27 ng/mL) revealed that optimal improvement of all clinical and immune parameters was achieved (as expected from effective AIT), irrespective of the VD level. Notably, the third analysis, carried out on one cohort of AIT patients that were also concomitantly taking VD3 as a food supplement (N = 19), was distinguished by an uppermost overall treatment outcome (the amelioration of symptoms, the lowest medication requirements, and a reduction in the total and allergen-specific IgE levels), as well as an increase in the allergen-specific tolerogenic memory T regulatory cells. These findings suggest that the endogenous VD level affects the allergy severity and allergen immunotherapy effectiveness. In addition, VD3 might be investigated as an add-on supplement to obtain the best out of immunotherapy in VD-deficient/-insufficient allergic patients. The immunogenic, but low-allergenic, mite allergoid used as the bioactive agent might have contributed to minimizing the allergic response and highlighting the immunological effects described here. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Immunotherapy)
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