Progress in Neurodevelopmental Disorders Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1160

Special Issue Editor


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Guest Editor
Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal
Interests: human genetics; neurosciences; neurodevelopmental disorders

Special Issue Information

Dear Colleagues,

Neurodevelopmental disorders encompass a broad spectrum of conditions that affect the growth and development of the brain and nervous system, leading to significant impairments in cognitive, behavioral, and social functioning. These disorders, ranging from autism spectrum disorder (ASD) to attention deficit hyperactivity disorder (ADHD) and intellectual disability, impose a heavy burden on individuals, families, and societies worldwide. Despite significant advances in diagnosis and management, the underlying mechanisms and treatment options for neurodevelopmental disorders remain elusive.

This Special Issue will delve into the molecular basis of neurodevelopmental disorders. These studies explore genetic variants, epigenetic modifications, and gene expression patterns associated with ASD, ADHD, and other disorders, shedding light on the complex interplay between genetic and environmental factors in disease onset and progression. Furthermore, we also include articles and reviews that synthesize the current understanding of the clinical manifestations, diagnostic criteria, and therapeutic approaches for neurodevelopmental disorders. These studies aim to provide a comprehensive overview of the field and highlight emerging trends and future directions.

In conclusion, this Special Issue, entitled "Progress in Neurodevelopmental Disorders Research", will represent a valuable resource for researchers, clinicians, and policymakers interested in advancing the understanding and treatment of these complex and devastating conditions. We hope that the insights and findings presented here will inspire further collaboration and innovation, ultimately leading to better outcomes for individuals with neurodevelopmental disorders.

Dr. Catarina Morais Seabra
Guest Editor

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Keywords

  • neurodevelopmental disorders
  • autism spectrum disorder
  • attention deficit hyperactivity disorder

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Published Papers (1 paper)

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Review

25 pages, 2874 KiB  
Review
A Biopsychosocial Overview of Speech Disorders: Neuroanatomical, Genetic, and Environmental Insights
by Diya Jaishankar, Tanvi Raghuram, Bhuvanesh Kumar Raju, Divyanka Swarna, Shriya Parekh, Narendra Chirmule and Vikramsingh Gujar
Biomedicines 2025, 13(1), 239; https://doi.org/10.3390/biomedicines13010239 - 20 Jan 2025
Viewed by 803
Abstract
Speech disorders encompass a complex interplay of neuroanatomical, genetic, and environmental factors affecting individuals’ communication ability. This review synthesizes current insights into the neuroanatomy, genetic underpinnings, and environmental influences contributing to speech disorders. Neuroanatomical structures, such as Broca’s area, Wernicke’s area, the arcuate [...] Read more.
Speech disorders encompass a complex interplay of neuroanatomical, genetic, and environmental factors affecting individuals’ communication ability. This review synthesizes current insights into the neuroanatomy, genetic underpinnings, and environmental influences contributing to speech disorders. Neuroanatomical structures, such as Broca’s area, Wernicke’s area, the arcuate fasciculus, and basal ganglia, along with their connectivity, play critical roles in speech production, comprehension, and motor coordination. Advances in the understanding of intricate brain networks involved in language offer insights into typical speech development and the pathophysiology of speech disorders. Genetic studies have identified key genes involved in neural migration and synaptic connectivity, further elucidating the role of genetic mutations in speech disorders, such as stuttering and speech sound disorders. Beyond the biological mechanisms, this review explores the profound impact of psychological factors, including anxiety, depression, and neurodevelopmental conditions, on individuals with speech disorders. Psychosocial comorbidities often exacerbate speech disorders, complicating diagnosis and treatment and underscoring the need for a holistic approach to managing these conditions. Future directions point toward leveraging genetic testing, digital technologies, and personalized therapies, alongside addressing the psychosocial dimensions, to improve outcomes for individuals with speech disorders. This comprehensive overview aims to inform future research and therapeutic advancements, particularly in treating fluency disorders like stuttering. Full article
(This article belongs to the Special Issue Progress in Neurodevelopmental Disorders Research)
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