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Biomedicines
Special Issues
Current Perspectives on Human Papillomavirus (HPV)
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Current Perspectives on Human Papillomavirus (HPV)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 4774

Special Issue Editors

Dr. Vanja Kaliterna

E-Mail Website
Guest Editor
1. Teaching Institute of Public Health of Split-Dalmatia County, Split, Croatia
2. University Department of Health Studies, University of Split, 21000 Split, Croatia
Interests: Human Papillomavirus (HPV)
Dr. Tomislav Meštrović

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University North, University Centre Varaždin, Varaždin, Croatia
Interests: microbiome; microbiota; gut microbiome; vaginal microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A highly prevalent human papillomavirus (HPV) infection can be responsible for a myriad of health issues, thus unveiling the need for a comprehensive overview of the latest research developments and insights into various aspects of this viral agent. This Special Issue aims to cover the most important aspects of human papillomavirus (HPV) infections, including fundamental research, diagnostics, treatment and prevention strategies. The scope of this Special Issue includes research on the biology and molecular mechanisms of HPV, as well as studies on the clinical aspects of HPV-related diseases.

In terms of diagnostics and treatment, the Special Issue will focus on the latest advancements in diagnostic methods, particularly concerning molecular tests and their use in disease screening strategies, but also novel treatment approaches such as immunotherapy and targeted treatments. Additionally, the Special Issue will provide insights into HPV-related diseases, including the associated complications and malignancies. Likewise, prevention strategies represent an important focus of this Special Issue, including vaccination and screening as two crucial strategies for prevention and early detection, respectively.

We invite experts from the scientific fields of microbiology, virology, pathology, infectious diseases, dermatology, oncology, gynecology and urology to share their latest research results, experiences and innovations in the field of HPV research and prevention.

Dr. Vanja Kaliterna
Dr. Tomislav Meštrović
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Human Papillomavirus (HPV)
  • molecular mechanisms
  • diagnosis
  • treatment
  • prevention
  • vaccination
  • screening
  • immunotherapy
  • cancer

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Published Papers (3 papers)

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Research

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10 pages, 1040 KiB  
Communication
Association of Methylated DNA Markers with High-Risk HPV Infections in Oral Site and Precancer Anal Lesions in HIV-Positive MSM
by Silvia Pauciullo, Daniele Colombo, Verdiana Zulian, Roberta Sciamanna, Antonio Coppola, Alessandra Scarabello, Franca Del Nonno and Anna Rosa Garbuglia
Biomedicines 2024, 12(8), 1838; https://doi.org/10.3390/biomedicines12081838 - 13 Aug 2024
Viewed by 945
Abstract
Background: Human papillomavirus (HPV) infection is linked to several cancers, including anal and oral cancers. The incidence of anal cancer is particularly high among HIV-positive men who have sex with men (MSM). DNA methylation markers have shown promise as biomarkers for identifying precancerous [...] Read more.
Background: Human papillomavirus (HPV) infection is linked to several cancers, including anal and oral cancers. The incidence of anal cancer is particularly high among HIV-positive men who have sex with men (MSM). DNA methylation markers have shown promise as biomarkers for identifying precancerous lesions and cancer in HPV-infected individuals. The aim of this study was to investigate the correlation of DNA methylation with HPV infection in oral samples and the correlation of DNA methylation with lesion degree in the anal samples of HIV-positive MSM. Methods: This study investigated DNA methylation in oral and anal samples from HIV-positive MSM at the National Institute for Infectious Diseases (INMI) in Rome, Italy. Exfoliated oral epithelial cells and anal samples were collected and analyzed for 28 HPV genotypes using the Allplex 28 HPV assay. DNA methylation was assessed with the PrecursorM+ kit for oral samples and the AnoGyn kit for anal samples, focusing on the promoter regions of specific genes. Results: The study included 63 participants, with a median age of 49 and a median CD4+ count of 705 cells/µL. The oral samples showed HPV16 as the most common type, with 22% testing positive for DNA methylation. The anal samples exhibited HPV-related methylation changes linked to cytological lesions, with a 30% increase in the observed ddCt ratio. Significant differences were found in both ASCL1 and ZNF582 genes, particularly for HSILvsNILM and HSILvsLSIL lesions. Of the samples with an increased ddCt ratio, 80% were from patients over 35 years old, and multiple HPV infections were common. Conclusions: DNA methylation markers could be valuable in identifying high-risk HPV infections in oral samples and detecting potential precancerous lesions in anal samples. These markers may enhance the early detection and prevention strategies for HPV-related cancers in high-risk populations, with follow-up data indicating potential for monitoring lesion progression. Full article
(This article belongs to the Special Issue Current Perspectives on Human Papillomavirus (HPV))
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13 pages, 432 KiB  
Article
Risk Factors for the Anal and Oral Human Papillomavirus (HPV) Infections among Women with Severe Cervical Lesions: A Prospective Case—Control Study
by Monika Nipčová Džundová, Borek Sehnal, Michal Zikán, Roman Kocián, Olga Dubová, Petr Hubka, Lukáš Dostálek, Pavel Kabele, Tomáš Brtnický and Jiri Slama
Biomedicines 2023, 11(12), 3183; https://doi.org/10.3390/biomedicines11123183 - 29 Nov 2023
Cited by 3 | Viewed by 1449
Abstract
The carcinogenicity of HPV infection in the anogenital and oropharyngeal regions is broadly accepted. The aim of the study was to define risk factors for anal and oral HPV infections in high-risk patients with biopsy-proven severe cervical lesions (CIN2+). Altogether immunocompetent 473 females [...] Read more.
The carcinogenicity of HPV infection in the anogenital and oropharyngeal regions is broadly accepted. The aim of the study was to define risk factors for anal and oral HPV infections in high-risk patients with biopsy-proven severe cervical lesions (CIN2+). Altogether immunocompetent 473 females with CIN2+ were categorized into the study group and another 245 women into the control group. The strongest risk factor for anal HPV infection was the presence of cervical HPV infection (p < 0.001). Furthermore, ten or more lifetime sexual partners (p = 0.013), a sexual non-coital contact with the anal area (p < 0.001), and actively practicing anal-penetrative intercourse (p < 0.001) were significantly associated with anal HPV. A history of genital warts in the woman (p = 0.010) and the presence of genital warts in the male partner (p = 0.029) were found statistically significant for the risk of oral HPV infection. Our data suggest that the presence of HPV infection, especially high-risk genotypes, in one anatomical site poses the greatest risk for HPV infection in another anatomical site. The cervix is the main reservoir of infection, but the risk factors for anal and oral HPV infections are dissimilar according to different anatomical distances and more complex routes of transmission. Full article
(This article belongs to the Special Issue Current Perspectives on Human Papillomavirus (HPV))
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Review

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14 pages, 783 KiB  
Review
Skin Lesions Caused by HPV—A Comprehensive Review
by Laura Maghiar, Mircea Sandor, Liliana Sachelarie, Ruxandra Bodog and Anca Huniadi
Biomedicines 2024, 12(9), 2098; https://doi.org/10.3390/biomedicines12092098 - 13 Sep 2024
Viewed by 1840
Abstract
This narrative review provides a comprehensive analysis of skin lesions caused by human papillomavirus (HPV). Human papillomavirus is an infection involving a virus that is omnipresent and can range from benign wart lesions to malignant skin growths. This review includes an analysis of [...] Read more.
This narrative review provides a comprehensive analysis of skin lesions caused by human papillomavirus (HPV). Human papillomavirus is an infection involving a virus that is omnipresent and can range from benign wart lesions to malignant skin growths. This review includes an analysis of the skin manifestations caused by HPV, and the need for continued successful diagnostic techniques and treatment methods, given the increasing rates of infection among people worldwide. We reviewed all 135 studies related to pathophysiology involving skin, risk factors, and early detection methods like biopsy and molecular testing, from 2000 to 2023. The current treatments, including cryotherapy and laser therapy, are discussed, while the review emphasizes the role of HPV vaccination in preventing infection. Recommendations for the future would involve the improvement of public education and increased vaccine coverage, together with innovative therapies toward better management or control of skin diseases associated with the human papillomavirus (HPV). By advancing these recommendations, we will be in a better position to prevent and treat HPV skin conditions, thus improving the health condition of the general public across the world. Full article
(This article belongs to the Special Issue Current Perspectives on Human Papillomavirus (HPV))
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