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Biomedicines
Special Issues
Epigenetic Regulation in Cancer Progression
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Epigenetic Regulation in Cancer Progression

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2006

Special Issue Editor

Dr. Yonghwan Shin

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
Interests: epigenetics; DNA methylation; histone modifications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer progression represents a multifaceted journey influenced not only by genetic mutations, but also the intricate landscape of epigenetic changes, which delicately modulate gene expression patterns. Epigenetic modifications, spanning DNA methylation, histone alterations and non-coding RNA regulation, wield substantial influence over gene expression, impacting pivotal cellular functions such as proliferation, differentiation and apoptosis. The dysregulation of these epigenetic mechanisms emerges as a driving force behind malignant transformation, tumor heterogeneity, metastasis and resistance to therapies across a spectrum of cancer types.

Furthermore, unraveling the nuanced interplay between genetic mutations and epigenetic alterations provides a comprehensive perspective on cancer pathogenesis and evolution. Integrative approaches, embracing genomics, epigenomics and systems biology, are illuminating novel therapeutic avenues by unveiling the synergistic effects of genetic and epigenetic dysregulation.

Dr. Yonghwan Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer progression
  • epigenetic regulation
  • gene expression
  • dysregulation
  • therapeutic targets

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Published Papers (1 paper)

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Review

19 pages, 562 KiB  
Review
Epigenetic Regulation of DNA Methylation and RNA Interference in Gastric Cancer: A 2024 Update
by Iulia Lupan, Vasile Bintintan, Diana Deleanu and Gabriel Samasca
Biomedicines 2024, 12(9), 2001; https://doi.org/10.3390/biomedicines12092001 - 3 Sep 2024
Viewed by 1598
Abstract
Gastric cancer (GC) remains a significant public health concern because of its lethality, underscoring the need for deeper insights into its molecular mechanisms. Recent studies have increasingly highlighted the role of epigenetic modifications as critical players in cancer progression. Despite their importance, research [...] Read more.
Gastric cancer (GC) remains a significant public health concern because of its lethality, underscoring the need for deeper insights into its molecular mechanisms. Recent studies have increasingly highlighted the role of epigenetic modifications as critical players in cancer progression. Despite their importance, research specifically addressing epigenetic factors in GC is relatively scarce. This paper seeks to bridge that gap by examining recent literature that elucidates the epigenetic landscape associated with GC. The investigation of long noncoding RNAs (lncRNAs) has revealed their substantial involvement in gene dysregulation and epigenetic alterations within GC tumors. Notably, lncRNAs such as LINC00853 and LINC01266 have been identified as significant contributors to the epigenetic modulation of gene expression. Furthermore, the overexpression of KAT5 and GPX4 has been shown to mitigate the antiproliferative effects resulting from the depletion of circRHOT1, suggesting a complex interplay between these molecules in GC pathophysiology. Another pivotal aspect of epigenetic regulation in GC involves modifications in N6-methyladenosine (m6A), which play crucial roles in mRNA maturation processes such as splicing, export, degradation, and translation. m6A modifications are known for their influence on various cancer-related pathways, thus presenting a potential avenue for targeted interventions. Our findings indicate that the most pronounced instances of epigenetic dysregulation in GC can be traced back to the effects of long lncRNAs and alterations in m6A modification patterns. This underscores the urgent need for comprehensive investigations into these epigenetic factors, as a deeper understanding could lead to enhanced diagnostic markers and innovative therapeutic strategies. The integration of genetic and epigenetic considerations is essential for advancing the field of GC research. This synthesis of recent findings concerning epigenetic regulation offers valuable insights that could inform future studies and therapeutic developments. There is a critical need for ongoing research to elucidate the complexities of epigenetic modifications in GC, ultimately improving patient outcomes through tailored interventions. Full article
(This article belongs to the Special Issue Epigenetic Regulation in Cancer Progression)
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