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Biomedicines
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Advanced Biomaterials for Tissue Regeneration and Wound Healing Support
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Advanced Biomaterials for Tissue Regeneration and Wound Healing Support

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 13531

Special Issue Editors

Dr. Jáchym Rosendorf

E-Mail Website
Guest Editor
Department of Surgery, University Hospital in Pilsen, Faculty of Medicine in Pilsen, Charles University, Czech Republic
Interests: colorectal surgery; laparoscopic surgery; robotic surgery; animal experiment; experimental development and application of bioengineered materials for gastrointestinal surgery; gastrointestinal wound healing
Dr. Vladimíra Moulisová

E-Mail Website
Guest Editor
Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic
Interests: regenerative medicine; biomaterial functionalization; endothelial cells; vasculogenesis; fluorescence microscopy; stem cell differentiation; tissue engineering; fluorescence; biomaterials; whole liver decellularization; tissue recellularization; scaffold development

Special Issue Information

Dear Colleagues,

Medicine has seen tremendous progress over the past few decades. This rapid development has been supported, among other things, by a number of important discoveries in the field of biomedical research. New complex modern materials have made it possible to develop many special medical devices and implantable products for both treatment and diagnostics. Bioengineered materials are applied in a broad range of medical research, including drug delivery systems, regenerated human tissues, materials for wound healing support, biosensors, etc.

The processes of tissue regeneration and wound healing are far from being well described, and current medical means for tissue healing enhancement are quite limited. This issue is therefore aimed especially at projects focusing on regenerative medicine and wound healing. All original articles studying novel and structurally or chemically innovative materials either of biological or synthetic origin are welcome, as well as reviews dealing with similar issues. This issue also aims to bring together research that, in addition to information about the material itself, also brings new knowledge about the basic physiological and pathophysiological processes involved in tissue healing and regeneration, as this chapter of knowledge is remarkably unexplored.

Dr. Jáchym Rosendorf
Dr. Vladimíra Moulisová
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • wound healing
  • scaffolds
  • tissue regeneration
  • drug delivery systems

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Published Papers (6 papers)

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Research

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21 pages, 4899 KiB  
Article
Low-Temperature Calcium Phosphate Ceramics Can Modulate Monocytes and Macrophages Inflammatory Response In Vitro
by Vladislav V. Minaychev, Polina V. Smirnova, Margarita I. Kobyakova, Anastasia Yu. Teterina, Igor V. Smirnov, Vladimir D. Skirda, Artem S. Alexandrov, Marat R. Gafurov, Mikhail A. Shlykov, Kira V. Pyatina, Anatoliy S. Senotov, Pavel S. Salynkin, Roman S. Fadeev, Vladimir S. Komlev and Irina S. Fadeeva
Biomedicines 2024, 12(2), 263; https://doi.org/10.3390/biomedicines12020263 - 24 Jan 2024
Cited by 1 | Viewed by 1550
Abstract
Creating bioactive materials for bone tissue regeneration and augmentation remains a pertinent challenge. One of the most promising and rapidly advancing approaches involves the use of low-temperature ceramics that closely mimic the natural composition of the extracellular matrix of native bone tissue, such [...] Read more.
Creating bioactive materials for bone tissue regeneration and augmentation remains a pertinent challenge. One of the most promising and rapidly advancing approaches involves the use of low-temperature ceramics that closely mimic the natural composition of the extracellular matrix of native bone tissue, such as Hydroxyapatite (HAp) and its phase precursors (Dicalcium Phosphate Dihydrate—DCPD, Octacalcium Phosphate—OCP, etc.). However, despite significant scientific interest, the current knowledge and understanding remain limited regarding the impact of these ceramics not only on reparative histogenesis processes but also on the immunostimulation and initiation of local aseptic inflammation leading to material rejection. Using the stable cell models of monocyte-like (THP-1ATRA) and macrophage-like (THP-1PMA) cells under the conditions of LPS-induced model inflammation in vitro, the influence of DCPD, OCP, and HAp on cell viability, ROS and intracellular NO production, phagocytosis, and the secretion of pro-inflammatory cytokines was assessed. The results demonstrate that all investigated ceramic particles exhibit biological activity toward human macrophage and monocyte cells in vitro, potentially providing conditions necessary for bone tissue restoration/regeneration in the peri-implant environment in vivo. Among the studied ceramics, DCPD appears to be the most preferable for implantation in patients with latent inflammation or unpredictable immune status, as this ceramic had the most favorable overall impact on the investigated cellular models. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration and Wound Healing Support)
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16 pages, 1692 KiB  
Article
Traumatic Fracture Treatment: Calcium Phosphate Bone Substitute Case–Control Study in Humerus, Radius, Tibia Fractures—Assessing Efficacy and Recovery Outcomes
by Gero Knapp, Jonas Pawelke, Christian Heiss, Sera Elmas, Vithusha Vinayahalingam and Thaqif ElKhassawna
Biomedicines 2023, 11(10), 2862; https://doi.org/10.3390/biomedicines11102862 - 22 Oct 2023
Cited by 2 | Viewed by 1560
Abstract
To date, insufficient investigation has been carried out on the biocompatibility of synthetic bioactive bone substitute materials after traumatically induced bone fractures in clinical conditions. This study encompasses the safety, resorption, healing process, and complications of surgical treatment. Our current hypothesis posits that [...] Read more.
To date, insufficient investigation has been carried out on the biocompatibility of synthetic bioactive bone substitute materials after traumatically induced bone fractures in clinical conditions. This study encompasses the safety, resorption, healing process, and complications of surgical treatment. Our current hypothesis posits that calcium phosphate-based bone substitutes could improve bone healing. In this retrospective case–control study, over 290 patients who underwent surgical treatment for acute fractures were examined. Bone defects were augmented with calcium phosphate-based bone substitute material (CP) in comparison to with empty defect treatment (ED) between 2011 and 2018. A novel scoring system for fracture healing was introduced to assess bone healing in up to six radiological follow-up examinations. Furthermore, demographic data, concomitant diseases, and complications were subjected to analysis. Data analysis disclosed significantly fewer postoperative complications in the CP group relative to the ED group (p < 0.001). The CP group revealed decreased risks of experiencing complications (p < 0.001), arthrosis (p = 0.01), and neurological diseases (p < 0.001). The fracture edge, the fracture gap, and the articular surface were definably enhanced. Osteosynthesis and general bone density demonstrated similarity (p > 0.05). Subgroup analysis focusing on patients aged 64 years and older revealed a diminished complication incidence within the CP group (p = 0.025). Notably, the application of CP bone substitute materials showed discernible benefits in geriatric patients, evident by decreased rates of pseudarthrosis (p = 0.059). Intermediate follow-up evaluations disclosed marked enhancements in fracture gap, edge, and articular surface conditions through the utilization of CP-based substitutes (p < 0.05). In conclusion, calcium phosphate-based bone substitute materials assert their clinical integrity by demonstrating safety in clinical applications. They substantiate an accelerated early osseous healing trajectory while concurrently decreasing the severity of complications within the bone substitute cohort. In vivo advantages were demonstrated for CP bone graft substitutes. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration and Wound Healing Support)
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28 pages, 13284 KiB  
Article
Comparison of Autografts and Biodegradable 3D-Printed Composite Scaffolds with Osteoconductive Properties for Tissue Regeneration in Bone Tuberculosis
by Tatiana I. Vinogradova, Mikhail S. Serdobintsev, Evgenia G. Korzhikova-Vlakh, Viktor A. Korzhikov-Vlakh, Alexander S. Kaftyrev, Natalya M. Blum, Natalya Yu. Semenova, Dilyara S. Esmedlyaeva, Marina E. Dyakova, Yulia A. Nashchekina, Marine Z. Dogonadze, Natalia V. Zabolotnykh and Petr K. Yablonsky
Biomedicines 2023, 11(8), 2229; https://doi.org/10.3390/biomedicines11082229 - 8 Aug 2023
Cited by 3 | Viewed by 2051
Abstract
Tuberculosis remains one of the major health problems worldwide. Besides the lungs, tuberculosis affects other organs, including bones and joints. In the case of bone tuberculosis, current treatment protocols include necrectomy in combination with conventional anti-tuberculosis therapy, followed by reconstruction of the resulting [...] Read more.
Tuberculosis remains one of the major health problems worldwide. Besides the lungs, tuberculosis affects other organs, including bones and joints. In the case of bone tuberculosis, current treatment protocols include necrectomy in combination with conventional anti-tuberculosis therapy, followed by reconstruction of the resulting bone defects. In this study, we compared autografting and implantation with a biodegradable composite scaffold for bone-defect regeneration in a tuberculosis rabbit model. Porous three-dimensional composite materials were prepared by 3D printing and consisted of poly(ε-caprolactone) filled with nanocrystalline cellulose modified with poly(glutamic acid). In addition, rabbit mesenchymal stem cells were adhered to the surface of the composite scaffolds. The developed tuberculosis model was verified by immunological subcutaneous test, real-time polymerase chain reaction, biochemical markers and histomorphological study. Infected animals were randomly divided into three groups, representing the infection control and two experimental groups subjected to necrectomy, anti-tuberculosis treatment, and plastic surgery using autografts or 3D-composite scaffolds. The lifetime observation of the experimental animals and analysis of various biochemical markers at different time periods allowed the comparison of the state of the animals between the groups. Micro-computed tomography and histomorphological analysis enabled the evaluation of osteogenesis, inflammation and cellular changes between the groups, respectively. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration and Wound Healing Support)
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17 pages, 6196 KiB  
Article
Mechanical Characterization of 3D-Printed Patterned Membranes for Cardiac Tissue Engineering: An Experimental and Numerical Study
by Aurelia Poerio, Bertrand Guibert, Mélanie M. Leroux, João F. Mano, Franck Cleymand and Jean-Philippe Jehl
Biomedicines 2023, 11(3), 963; https://doi.org/10.3390/biomedicines11030963 - 21 Mar 2023
Cited by 3 | Viewed by 1904
Abstract
A myocardial infarction can cause irreversible damage to the heart muscle. A promising approach for the treatment of myocardial infarction and prevention of severe complications is the application of cardiac patches or epicardial restraint devices. The challenge for the fabrication of cardiac patches [...] Read more.
A myocardial infarction can cause irreversible damage to the heart muscle. A promising approach for the treatment of myocardial infarction and prevention of severe complications is the application of cardiac patches or epicardial restraint devices. The challenge for the fabrication of cardiac patches is the replication of the fibrillar structure of the myocardium, in particular its anisotropy and local elasticity. In this study, we developed a chitosan–gelatin–guar gum-based biomaterial ink that was fabricated using 3D printing to create patterned anisotropic membranes. The experimental results were then used to develop a numerical model able to predict the elastic properties of additional geometries with tunable elasticity that could easily match the mechanical properties of the heart tissue (particularly the myocardium). Full article
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration and Wound Healing Support)
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20 pages, 4528 KiB  
Article
Experimentally Induced Burns in Rats Treated with Innovative Polymeric Films Type Therapies
by Oxana-Madalina Grosu, Oana-Maria Dragostin, Ioannis Gardikiotis, Carmen Lidia Chitescu, Elena Lacramioara Lisa, Alexandra-Simona Zamfir, Luminita Confederat, Ionut Dragostin, Maria Dragan, Catalina Daniela Stan and Carmen-Lacramioara Zamfir
Biomedicines 2023, 11(3), 852; https://doi.org/10.3390/biomedicines11030852 - 10 Mar 2023
Cited by 3 | Viewed by 2297
Abstract
Considering that microbial resistance to antibiotics is becoming an increasingly widespread problem, burn management, which usually includes the use of topical antimicrobial dressings, is still facing difficulties regarding their efficiency to ensure rapid healing. In this context, the main objective of this research [...] Read more.
Considering that microbial resistance to antibiotics is becoming an increasingly widespread problem, burn management, which usually includes the use of topical antimicrobial dressings, is still facing difficulties regarding their efficiency to ensure rapid healing. In this context, the main objective of this research is to include new oxytetracycline derivatives in polymeric-film-type dressings for the treatment of wounds caused by experimentally induced burns in rats. The structural and physico-chemical properties of synthesized oxytetracycline derivatives and the corresponding membranes were analyzed by FT-IR and MS spectroscopy, swelling ability and biodegradation capacity. In vitro antimicrobial activity using Gram-positive and Gram-negative bacterial strains and pathogenic yeasts, along with an in vivo study of a burn wound model induced in Wistar rats, was also analyzed. The newly obtained polymeric films, namely chitosan-oxytetracycline derivative membranes, showed good antimicrobial activity noticed in the tested strains, a membrane swelling ratio (MSR) of up to 1578% in acidic conditions and a biodegradation rate of up to 15.7% on day 7 of testing, which are important required characteristics for the tissue regeneration process, after the production of a burn. The in vivo study proved that chitosan-derived oxytetracycline membranes showed also improved healing effects which contributes to supporting the idea of using them for the treatment of wounds caused by burns. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration and Wound Healing Support)
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Review

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18 pages, 1396 KiB  
Review
The Synergistic Effects of Hyaluronic Acid and Platelet-Rich Plasma for Patellar Chondropathy
by Fábio Ramos Costa, Márcia da Silva Santos, Rubens Andrade Martins, Cláudia Bruno Costa, Paulo César Hamdan, Marcos Britto Da Silva, Gabriel Ohana Marques Azzini, Luyddy Pires, Zartur Menegassi, Gabriel Silva Santos and José Fábio Lana
Biomedicines 2024, 12(1), 6; https://doi.org/10.3390/biomedicines12010006 - 19 Dec 2023
Cited by 3 | Viewed by 3521
Abstract
Musculoskeletal disorders are increasingly prevalent worldwide, causing significant socioeconomic burdens and diminished quality of life. Notably, patellar chondropathy (PC) is among the most widespread conditions affecting joint structures, resulting in profound pain and disability. Hyaluronic acid (HA) and platelet-rich plasma (PRP) have emerged [...] Read more.
Musculoskeletal disorders are increasingly prevalent worldwide, causing significant socioeconomic burdens and diminished quality of life. Notably, patellar chondropathy (PC) is among the most widespread conditions affecting joint structures, resulting in profound pain and disability. Hyaluronic acid (HA) and platelet-rich plasma (PRP) have emerged as reliable, effective, and minimally invasive alternatives. Continuous research spanning from laboratory settings to clinical applications demonstrates the numerous advantages of both products. These encompass lubrication, anti-inflammation, and stimulation of cellular behaviors linked to proliferation, differentiation, migration, and the release of essential growth factors. Cumulatively, these benefits support the rejuvenation of bone and cartilaginous tissues, which are otherwise compromised due to the prevailing degenerative and inflammatory responses characteristic of tissue damage. While existing literature delves into the physical, mechanical, and biological facets of these products, as well as their commercial variants and distinct clinical uses, there is limited discussion on their interconnected roles. We explore basic science concepts, product variations, and clinical strategies. This comprehensive examination provides physicians with an alternative insight into the pathophysiology of PC as well as biological mechanisms stimulated by both HA and PRP that contribute to tissue restoration. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Tissue Regeneration and Wound Healing Support)
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