Mitochondria and Central Nervous System Disorders: 3rd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1459

Special Issue Editors


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Guest Editor
1. Institute of Human Genetics, University of Cologne, Cologne, Germany
2. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany
Interests: mitochondria; translation; autophagy; neurons
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine, University of Udine, 33100 Udine, Italy
Interests: mitochondria; metabolism; transcriptomics; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the previous Special Issues, we are pleased to announce the launch of a third edition, “Mitochondria and Central Nervous System Disorders: 3rd Edition”.

In the past several decades, a mitochondria-centric vision has developed in the fields of cell, organ, and organismal physiology, demonstrating exponential growth. This is likely due to the number of findings highlighting the contribution of these organelles to cell/tissue bioenergetics, death programmes, and metabolism. Dysfunctional mitochondria or dysfunctional mitochondria dynamics (a term that includes processes dictating the morphology of these organelles, their subcellular distribution/transport, or their interaction with other organelles, consequently influencing their function) have been linked to many pathological conditions, widespread among the entire human body. However, these alterations appear to more strongly affect the highly specialized and delicate cells of the central nervous system (CNS), contributing to the onset of a variety of diseases, ranging from rare childhood disorders (e.g., Leigh syndrome or mitochondrial encephalopathy with lactic acidosis and stroke-like episodes) to more common age-related neurodegenerative conditions (e.g., dementia, Alzheimer’s disease, and Parkinson’s disease).

This Special Issue is designed to emphasize the link between the (dys)function of mitochondria and CNS disorders, likely highlighting common or discrepant mechanisms underlying them. In this regard, we would like to invite review articles that address the above-mentioned topics or original research papers providing new evidence on the mitochondria–CNS pathological connection.

We look forward to reading your contributions.

Dr. Marta Zaninello
Dr. Camilla Bean
Guest Editors

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Keywords

  • mitochondria
  • metabolism
  • neurodegeneration
  • neuroinflammation
  • ageing
  • central nervous system

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Published Papers (2 papers)

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Research

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18 pages, 3494 KiB  
Article
Remodeling of Mitochondria–Endoplasmic Reticulum Contact Sites Accompanies LUHMES Differentiation
by Emad Norouzi Esfahani, Tomas Knedlik, Sang Hun Shin, Ana Paula Magalhães Rebelo, Agnese De Mario, Caterina Vianello, Luca Persano, Elena Rampazzo, Paolo Edomi, Camilla Bean, Dario Brunetti, Luca Scorrano, Samuele Greco, Marco Gerdol and Marta Giacomello
Biomolecules 2025, 15(1), 126; https://doi.org/10.3390/biom15010126 - 14 Jan 2025
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Abstract
Neural progenitor cells (NPCs) are often used to study the subcellular mechanisms underlying differentiation into neurons in vitro. Works published to date have focused on the pathways that distinguish undifferentiated NPCs from mature neurons, neglecting the earlier and intermediate stages of this process. [...] Read more.
Neural progenitor cells (NPCs) are often used to study the subcellular mechanisms underlying differentiation into neurons in vitro. Works published to date have focused on the pathways that distinguish undifferentiated NPCs from mature neurons, neglecting the earlier and intermediate stages of this process. Current evidence suggests that mitochondria interaction with the ER is fundamental to a wide range of intracellular processes. However, it is not clear whether and how the mitochondria–ER interactions differ between NPCs and their differentiated counterparts. Here we take advantage of the widely used NPC line LUHMES to provide hints on the mitochondrial dynamic trait changes that occur during the first stage of their maturation into dopaminergic-like neurons. We observed that the morphology of mitochondria, their interaction with the ER, and the expression of several mitochondria–ER contact site resident proteins change, which suggests the potential contribution of mitochondria dynamics to NPC differentiation. Further studies will be needed to explore in depth these changes, and their functional outcomes, which may be relevant to the scientific community focusing on embryonic neurogenesis and developmental neurotoxicity. Full article
(This article belongs to the Special Issue Mitochondria and Central Nervous System Disorders: 3rd Edition)
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Review

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17 pages, 737 KiB  
Review
Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment
by Keiko Iwata, Masafumi Noguchi and Norihito Shintani
Biomolecules 2025, 15(2), 184; https://doi.org/10.3390/biom15020184 - 27 Jan 2025
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Abstract
Mitochondria are essential for brain function, and accumulating evidence from postmortem brain studies, neuroimaging, and basic research indicates mitochondrial impairments in patients with psychiatric disorders. Restoring mitochondrial function therefore represents a promising therapeutic strategy for these conditions. Mitochondrial transplantation, an innovative approach that [...] Read more.
Mitochondria are essential for brain function, and accumulating evidence from postmortem brain studies, neuroimaging, and basic research indicates mitochondrial impairments in patients with psychiatric disorders. Restoring mitochondrial function therefore represents a promising therapeutic strategy for these conditions. Mitochondrial transplantation, an innovative approach that uses functional mitochondria to repair damaged cells, has demonstrated efficacy through various delivery methods in cell, animal, and animal disease models. This review explores the critical link between mitochondria and psychiatric disorders and provides an overview of mitochondrial transplantation as a therapeutic intervention. It highlights recent advances in mitochondrial transplantation in animal models of psychiatric disorders, focusing on delivery methods, the timing of administration, and the integration of exogenous mitochondria into brain cells. The potential therapeutic effects and the mechanisms that underlie these effects are discussed. Additionally, this review evaluates the clinical relevance, challenges, and future strategies for the application of mitochondrial transplantation in the treatment of psychiatric disorders. Full article
(This article belongs to the Special Issue Mitochondria and Central Nervous System Disorders: 3rd Edition)
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