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Biomolecules
Special Issues
Human Reproductive Biology: Uncertainties and Controversies
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Human Reproductive Biology: Uncertainties and Controversies

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Reproduction".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 3454

Special Issue Editors

Prof. Dr. Giuseppe Benagiano

E-Mail Website
Guest Editor
Department of Maternal and Child Health, Gynaecology and Urology, Sapienza University of Rome, Rome, Italy
Interests: reproductive endocrinology; adenomyosis; contraception; endometriosis; placental pathophysiology.
Special Issues, Collections and Topics in MDPI journals
Dr. Marwan Habiba

E-Mail Website
Guest Editor
Department of Health Sciences, University of Leicester and University Hospitals of Leicester, Leicester, UK
Interests: adenomyosis; the endometrium; medical ethics
Dr. Paola Bianchi

E-Mail Website
Guest Editor
Department of Medico-Surgical Sciences and Translational Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Rome, Italy
Interests: contraception; endometriosis; HMB; AUB

Special Issue Information

Dear Colleagues,

This Special Issue entitled “Human Reproductive Biology: Uncertainties and Controversies” aims at addressing issues in human reproduction research and more specifically in the field of molecular reproductive biology and medicine in those areas, where knowledge is still incomplete, or is subject to debate and disagreement.

We encourage scientists, pathologists and clinicians involved in the various fields of molecular reproduction to contribute to the debate over issues that are still unsettled or controversial.

High-quality review and research articles, as well as critiques and communications are all welcomed.

The potential topics include, but are not limited to:

  • Reproductive biology;
  • Reproductive immunology;
  • Reproductive medicine;
  • Reproductive endocrinology;
  • Molecular regulation of reproductive processes;
  • Embryo development;
  • New techniques and methods in reproductive biology;
  • Gametogenesis and fertilization.

The Special Issue welcomes contributions concerned with the detection and treatment of disease as well as those that address our understanding of physiological processes.

Prof. Dr. Giuseppe Benagiano
Dr. Marwan Habiba
Dr. Paola Bianchi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular reproduction
  • endometriosis
  • endometrium
  • implantation
  • decidualization
  • placenta
  • cellular senescence
  • prostaglandin
  • inflammation
  • pregnancy
  • reproduction
  • implantation
  • decidualization
  • endometriosis
  • assisted reproductive technology
  • molecular reproductive biology
  • reproductive biology
  • reproductive immunology
  • reproductive medicine
  • reproductive endocrinology
  • molecular regulation of reproductive processes
  • embryo development
  • reproductive biology
  • gametogenesis and fertilization

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

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18 pages, 2586 KiB  
Article
An Early Gestation Plasma Inflammasome in Rural Bangladeshi Women
by Hyunju Kim, Jacquelyn R. Bedsaul-Fryer, Kerry J. Schulze, Gwen Sincerbeaux, Sarah Baker, Casey M. Rebholz, Lee SF Wu, Joseph Gogain, Lena Cuddeback, James D. Yager, Luigi M. De Luca, Towfida J. Siddiqua and Keith P. West, Jr.
Biomolecules 2024, 14(7), 736; https://doi.org/10.3390/biom14070736 - 21 Jun 2024
Viewed by 1205
Abstract
Circulating α1-acid glycoprotein (AGP) and C-reactive protein (CRP) are commonly measured to assess inflammation, but these biomarkers fail to reveal the complex molecular biology of inflammation. We mined the maternal plasma proteome to detect proteins that covary with AGP and CRP. In 435 [...] Read more.
Circulating α1-acid glycoprotein (AGP) and C-reactive protein (CRP) are commonly measured to assess inflammation, but these biomarkers fail to reveal the complex molecular biology of inflammation. We mined the maternal plasma proteome to detect proteins that covary with AGP and CRP. In 435 gravida predominantly in <12-week gestation, we correlated the relative quantification of plasma proteins assessed via a multiplexed aptamer assay (SOMAScan®) with AGP and CRP, quantified by immunoassay. We defined a plasma inflammasome as protein correlates meeting a false discovery rate <0.05. We examined potential pathways using principal component analysis. A total of 147 and 879 of 6431 detected plasma proteins correlated with AGP and CRP, respectively, of which 61 overlapped with both biomarkers. Positive correlates included serum amyloid, complement, interferon-induced, and immunoregulatory proteins. Negative correlates were micronutrient and lipid transporters and pregnancy-related anabolic proteins. The principal components (PCs) of AGP were dominated by negatively correlated anabolic proteins associated with gestational homeostasis, angiogenesis, and neurogenesis. The PCs of CRP were more diverse in function, reflecting cell surface and adhesion, embryogenic, and intracellular and extra-hepatic tissue leakage proteins. The plasma proteome of AGP or CRP reveals wide proteomic variation associated with early gestational inflammation, suggesting mechanisms and pathways that merit future research. Full article
(This article belongs to the Special Issue Human Reproductive Biology: Uncertainties and Controversies)
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Review

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22 pages, 322 KiB  
Review
Adenomyosis and Abnormal Uterine Bleeding: Review of the Evidence
by Marwan Habiba, Sun-Wei Guo and Giuseppe Benagiano
Biomolecules 2024, 14(6), 616; https://doi.org/10.3390/biom14060616 - 23 May 2024
Cited by 3 | Viewed by 1839
Abstract
Background: Thomas Cullen described bleeding abnormalities and dysmenorrhea as the “expected” presentations of adenomyomas. Adenomyosis is included within the FIGO classification of structural causes of abnormal uterine bleeding (AUB). Nevertheless, this long-standing association has been questioned by some authors who reported a high [...] Read more.
Background: Thomas Cullen described bleeding abnormalities and dysmenorrhea as the “expected” presentations of adenomyomas. Adenomyosis is included within the FIGO classification of structural causes of abnormal uterine bleeding (AUB). Nevertheless, this long-standing association has been questioned by some authors who reported a high incidence of adenomyosis in uteri removed for indications other than AUB or dysmenorrhea. Here, we examine evidence for the link between adenomyosis and AUB. Methods: A comprehensive Medline literature review of all publications to October 2023. Results: Sixty-three articles were identified and included in the review. Despite a large body of studies, the available literature does not provide conclusive evidence of a link between adenomyosis and AUB. This is because of unsuitable study design, or poor characterization of the study population or of the inclusion or exclusion criteria. Additional challenges arise because of the lack of agreed criteria for diagnosing adenomyosis and the often absence of detailed assessment of menstrual blood loss. Adenomyosis often coexists with other conditions that have also been linked to similar symptoms, and many cases of adenomyosis are asymptomatic. Conclusion: Most of the existing literature and studies that addressed treatment outcome of adenomyosis started from the premise that a link between the condition and AUB had been proven. Yet, published information shows that aspects such a relationship is still uncertain. Further research is needed to address the relation between AUB and adenomyosis burden (or subtypes), distribution, and concomitant pathology. Full article
(This article belongs to the Special Issue Human Reproductive Biology: Uncertainties and Controversies)
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