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Biomolecules
Special Issues
Molecular Mechanisms of Human Skin Aging
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Molecular Mechanisms of Human Skin Aging

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 7756

Special Issue Editor

Dr. Taihao Quan

E-Mail Website
Guest Editor
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109-0609, USA
Interests: skin aging; ECM; fibroblast; skin cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin is the most extensive connective tissue of the body. Much like all other human organs, skin undergoes gradual changes as part of natural aging. However, unlike other organs, skin is consistently exposed to harmful environmental factors, such as solar ultraviolet radiation, leading to photoaging. Skin aging adversely affects a person’s susceptibility to other conditions, leading to increased fragility, compromised vascular support, delayed wound healing, and the onset of skin cancer. Notably, facial skin is often exposed and acts as a significant indicator of age, health, and disease, carrying considerable social and psychological implications. The primary objective of this Special Issue is to clarify our current understanding of the molecular mechanisms responsible for skin aging and to explore the preventive strategies. We eagerly anticipate receiving your submissions and look forward to compiling an informative and insightful collection of articles.

Dr. Taihao Quan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin aging
  • UV
  • extracellular matrix
  • fibroblast
  • prevention

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Published Papers (3 papers)

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Research

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11 pages, 4294 KiB  
Article
Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo
by Yan Yan, Hehui Quan, Chunfang Guo, Zhaoping Qin and Taihao Quan
Biomolecules 2024, 14(8), 900; https://doi.org/10.3390/biom14080900 - 25 Jul 2024
Viewed by 1488
Abstract
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin. Recently, we reported notable decreases in matrisome proteins in natural aging and [...] Read more.
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin. Recently, we reported notable decreases in matrisome proteins in natural aging and photoaging human skin. This study aims to investigate the mRNA expression of the core matrisome proteins in human skin, comparing young versus aged and sun-protected versus sun-exposed skin by quantitative real-time PCR and immunostaining. Our findings reveal a notable decrease in core matrisome transcription in aged skin. The mRNA expression of the core matrisome, such as collagen 1A1 (COL1A1), decorin, and dermatopontin, is significantly reduced in aged skin compared to its young skin. Yet, the majority of collagen mRNA expression levels of aged sun-exposed skin are similar to those found in young sun-exposed skin. This discrepancy is primarily attributable to a substantial decrease in collagen transcription in young sun-exposed skin, suggesting early molecular changes in matrisome transcription due to sun exposure, which preceded the emergence of clinical signs of photoaging. These findings shed light on the mRNA transcript profile of major matrisome proteins and their alterations in naturally aged and photoaged human skin, offering valuable insights into skin matrisome biology. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Human Skin Aging)
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15 pages, 1587 KiB  
Article
Fine Wrinkle Improvement through Bioactive Materials That Modulate EDAR and BNC2 Gene Expression
by Seonju Lee, Sanghyun Ye, Mina Kim, Hyejin Lee, Seung-Hyun Jun and Nae-Gyu Kang
Biomolecules 2024, 14(3), 279; https://doi.org/10.3390/biom14030279 - 26 Feb 2024
Cited by 2 | Viewed by 2542
Abstract
Skin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of several such wrinkle-improving materials, the demand for ingredients with [...] Read more.
Skin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of several such wrinkle-improving materials, the demand for ingredients with outstanding efficacy is increasing. Therefore, this study aimed to explore the mechanisms of wrinkle-related genes reported in previous genome-wide association studies (GWASs), identify materials that regulate these genes, and develop an effective anti-wrinkle formula containing the active ingredients that regulate the expression of these genes. We selected two candidate genes, EDAR and BNC2, that are reportedly related to periorbital wrinkles. We investigated their functions in the skin through in vitro experiments using human skin cell lines (keratinocytes and fibroblasts). Moreover, we identified ingredients that regulate the expression of these two genes and confirmed their efficacy through in vitro experiments using the skin cell lines. Finally, we developed a formula containing these ingredients and confirmed that it enhanced dermal collagen in the 3D skin and improved fine wrinkles under the eyes more effectively than retinol in humans, when applied for 8 weeks. Our results are significant and relevant, as we have discovered a special formula for wrinkle improvement with reliable efficacy that surpasses the efficacy of retinol and does not cause side-effects such as skin irritation. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Human Skin Aging)
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Review

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27 pages, 1483 KiB  
Review
3D Models Currently Proposed to Investigate Human Skin Aging and Explore Preventive and Reparative Approaches: A Descriptive Review
by Francesca Lombardi, Francesca Rosaria Augello, Alessia Ciafarone, Valeria Ciummo, Serena Altamura, Benedetta Cinque and Paola Palumbo
Biomolecules 2024, 14(9), 1066; https://doi.org/10.3390/biom14091066 - 26 Aug 2024
Cited by 2 | Viewed by 2940
Abstract
Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin functionality over time. Investigating the skin aging process requires thorough research using innovative technologies. This review explores the use of in vitro human 3D culture models, serving as valuable alternatives [...] Read more.
Skin aging is influenced by intrinsic and extrinsic factors that progressively impair skin functionality over time. Investigating the skin aging process requires thorough research using innovative technologies. This review explores the use of in vitro human 3D culture models, serving as valuable alternatives to animal ones, in skin aging research. The aim is to highlight the benefits and necessity of improving the methodology in analyzing the molecular mechanisms underlying human skin aging. Traditional 2D models, including monolayers of keratinocytes, fibroblasts, or melanocytes, even if providing cost-effective and straightforward methods to study critical processes such as extracellular matrix degradation, pigmentation, and the effects of secretome on skin cells, fail to replicate the complex tissue architecture with its intricated interactions. Advanced 3D models (organoid cultures, “skin-on-chip” technologies, reconstructed human skin, and 3D bioprinting) considerably enhance the physiological relevance, enabling a more accurate representation of skin aging and its peculiar features. By reporting the advantages and limitations of 3D models, this review highlights the importance of using advanced in vitro systems to develop practical anti-aging preventive and reparative approaches and improve human translational research in this field. Further exploration of these technologies will provide new opportunities for previously unexplored knowledge on skin aging. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Human Skin Aging)
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