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Biomolecules
Special Issues
Luminescent Probes and Bioconjugation Chemistries
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Luminescent Probes and Bioconjugation Chemistries

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 9014

Special Issue Editor

Dr. Letizia Sambri

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Guest Editor
Department of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum Università di Bologna, Bologna, Italy
Interests: green chemistry; bio-based advanced organic materials; drug delivery; surface functionalization of biomaterials; hydrogels; hybrid organic-inorganic nanosystems; organic and organometallic synthesis

Special Issue Information

Dear Colleagues,

Fluorescent probes are materials able to emit light after absorption of a radiation of an appropriate wavelength, and they have been exploited in a wide range of applications in various fields, from sensors, bioimaging, drug delivery, medical diagnostics and therapeutics, and material science. In addition, fluorescent techniques can display high sensitivity and rapid responses, offering great potential for visualizing biochemical processes and bioimaging in cells and living organisms.

In addition to the characteristics needed for an optimal detection, the cytotoxicity and biocompatibility of fluorescent probes must be carefully evaluated for successful bio-applications. To overcome these concerns, conjugation to biomolecules can be designed via the interaction with appropriate functional groups present on the probe’s structure. Several types of interactions can be used to attach biological molecules to fluorescent derivatives, spanning from non-covalent interactions to electrostatic ones and clearly including covalent bonds.

This Special Issue intends to present the current state-of-the-art in the investigation, synthesis and characterization of new derivatives that combine fluorescent probe to biomolecules; the benefit would be to exploit the peculiarity of the single components toward a construction of more powerful systems for different fields of application.

This Special Issue welcomes the submission of high-quality research papers as well as comprehensive reviews about new ideas and concepts about fluorescent bio-conjugated probes and their performances.

Topics of interest for publication in this Special Issue include, but are not limited, to the following:

  • Multifunctional materials
  • Fluorescence
  • Fluorescent nanomaterials
  • Bioconjugation
  • Biomaterials
  • Bioimaging
  • Drug delivery
  • Phototherapy

Dr. Letizia Sambri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multifunctional materials
  • fluorescence
  • fluorescent nanomaterials
  • bioconjugation
  • biomaterials
  • bioimaging
  • drug delivery
  • phototherapy
  • biotherapeutics

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Published Papers (3 papers)

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Research

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13 pages, 4511 KiB  
Article
Generalization of the Ratiometric Method to Extend pH Range Measurements of the BCECF Probe
by Alaa Tafech, Céline Beaujean, Yves Usson and Angélique Stéphanou
Biomolecules 2023, 13(3), 442; https://doi.org/10.3390/biom13030442 - 26 Feb 2023
Cited by 4 | Viewed by 2144
Abstract
There is a variety of fluorescent probes for pH measurements and which are mainly used for biological systems. In general, they can be classified into two groups. The first group includes fluorescent pH probes which exhibit a single fluorescence emission peak. For these [...] Read more.
There is a variety of fluorescent probes for pH measurements and which are mainly used for biological systems. In general, they can be classified into two groups. The first group includes fluorescent pH probes which exhibit a single fluorescence emission peak. For these probes, the fluorescence excitation profile is pH-dependent and the shape of the emission spectra remains almost constant. Hence, the ratiometric pH measurement–which makes pH determination independent of the probe concentration-is implemented when the excitation is performed at two excitation wavelengths and the fluorescence emission is measured at one wavelength. The second group exhibits a dual fluorescence emission peak. Here, each protonated or deprotonated form exhibits characteristics emission and/or absorption spectra. Shifts between spectra obtained for protonated and deprotonated species can be exploited in order to perform a ratiometric measurement. In this study we present a methodology that evaluates the precision of the ratiometric measurements based on multiple wavelengths excitation to determine the optimum wavelengths combination for pH determination in biological samples. This methodology using the BCECF probe is applied to measure the pH drift in cell culture medium. It exhibits a high precision and significantly extends the range of validity for pH measurements spanning from very acidic to basic. Full article
(This article belongs to the Special Issue Luminescent Probes and Bioconjugation Chemistries)
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14 pages, 3005 KiB  
Article
Iridium-Functionalized Cellulose Microcrystals as a Novel Luminescent Biomaterial for Biocomposites
by Mirko Maturi, Chiara Spanu, Andrea Baschieri, Mauro Comes Franchini, Erica Locatelli and Letizia Sambri
Biomolecules 2022, 12(9), 1165; https://doi.org/10.3390/biom12091165 - 23 Aug 2022
Cited by 1 | Viewed by 1790
Abstract
Microcrystalline cellulose (MCC) is an emerging material with outstanding properties in many scientific and industrial fields, in particular as an additive in composite materials. Its surface modification allows for the fine-tuning of its properties and the exploitation of these materials in a plethora [...] Read more.
Microcrystalline cellulose (MCC) is an emerging material with outstanding properties in many scientific and industrial fields, in particular as an additive in composite materials. Its surface modification allows for the fine-tuning of its properties and the exploitation of these materials in a plethora of applications. In this paper, we present the covalent linkage of a luminescent Ir-complex onto the surface of MCC, representing the first incorporation of an organometallic luminescent probe in this biomaterial. This goal has been achieved with an easy and sustainable procedure, which employs a Bronsted-acid ionic liquid as a catalyst for the esterification reaction of -OH cellulose surface groups. The obtained luminescent cellulose microcrystals display high and stable emissions with the incorporation of only a small amount of iridium (III). Incorporation of MCC-Ir in dry and wet matrices, such as films and gels, has been also demonstrated, showing the maintenance of the luminescent properties even in possible final manufacturers. Full article
(This article belongs to the Special Issue Luminescent Probes and Bioconjugation Chemistries)
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Review

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14 pages, 713 KiB  
Review
Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
by Tian Wang, Yingying Chen, Bo Wang, Xiaofan Gao and Mingfu Wu
Biomolecules 2022, 12(8), 1044; https://doi.org/10.3390/biom12081044 - 28 Jul 2022
Cited by 13 | Viewed by 4604
Abstract
Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of [...] Read more.
Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor elimination with a maximum preservation of normal tissue. Recently, second near-infrared region (NIR-II, 1000–1700 nm) fluorescence has shown great application potential in cancer theranostics due to its inherent advantages, such as great penetration capacity, minimal tissue absorption and scattering, and low autofluorescence. With the development of fluorescence imaging systems and fluorescent probes, tumor detection, margin definition, and individualized therapy can be achieved quickly, enabling an increasingly accurate diagnosis and treatment of cancer. Herein, this review introduces the role of NIR-II fluorescence imaging in cancer diagnosis and summarizes the representative applications of NIR-II image-guided treatment in cancer therapy. Ultimately, we discuss the present challenges and future perspectives on fluorescence imaging in the field of cancer theranostics and put forward our opinions on how to improve the accuracy and efficiency of cancer diagnosis and therapeutics. Full article
(This article belongs to the Special Issue Luminescent Probes and Bioconjugation Chemistries)
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