New Insights into Mesothelioma Immunotherapy

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2722

Special Issue Editor

Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, Toronto General Hospital, Princess Margaret Cancer Research Centre, University Health Network, University of Toronto, Toronto, ON M5G 1L7, Canada
Interests: mesothelioma; immunotherapy; immune checkpoint blockade; EMT gene signature

Special Issue Information

Dear Colleagues,

Mesothelioma is a rare cancer associated with exposure to asbestos. Malignant pleural mesothelioma (MPM) is the most common but the prognosis is quite poor. Conventional therapies have very limited efficacy for this disease. Immunotherapy has shown to be promising in preclinical studies and clinical trials; in particular, novel therapy targeting the immune check points has resulted in significant improvement of clinical outcome of the patients with mesothelioma.

The aim of this Special Issue of Biomolecules is to highlight the most recent progress in mesothelioma immunotherapy, which covers mesothelioma, including malignant pleural mesothelioma (MPM) and peritoneal mesothelioma, immunotherapy, immunology, immune profiling, immune response, immunosuppression, immune checkpoint and its inhibitor, immune score, tumor immune microenvironment, and EMT gene signature, etc. We encourage contributions on the topics above as well as molecular biology, genetics, multi-omics, bioinformatics, and meta-analysis computational studies. Basic study and clinical trials addressing this topic are both of particular interest.

Dr. Licun Wu
Guest Editor

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Keywords

  • mesothelioma/malignant pleural mesothelioma (MPM)/peritoneal mesothelioma
  • immunotherapy
  • immunology
  • immune profiling
  • immune response
  • immunosuppression
  • immune checkpoint/inhibitor
  • immune score
  • tumor immune microenvironment
  • epithelial-mesenchymal transition (EMT) gene signature

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Published Papers (1 paper)

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Review

15 pages, 3038 KiB  
Review
Omics Overview of the SPARC Gene in Mesothelioma
by Licun Wu and Marc de Perrot
Biomolecules 2023, 13(7), 1103; https://doi.org/10.3390/biom13071103 - 11 Jul 2023
Cited by 2 | Viewed by 2329
Abstract
The SPARC gene plays multiple roles in extracellular matrix synthesis and cell shaping, associated with tumor cell migration, invasion, and metastasis. The SPARC gene is also involved in the epithelial-mesenchymal transition (EMT) process, which is a critical phenomenon leading to a more aggressive [...] Read more.
The SPARC gene plays multiple roles in extracellular matrix synthesis and cell shaping, associated with tumor cell migration, invasion, and metastasis. The SPARC gene is also involved in the epithelial-mesenchymal transition (EMT) process, which is a critical phenomenon leading to a more aggressive cancer cell phenotype. SPARC gene overexpression has shown to be associated with poor survival in the mesothelioma (MESO) cohort from the TCGA database, indicating that this gene may be a powerful prognostic factor in MESO. Its overexpression is correlated with the immunosuppressive tumor microenvironment. Here, we summarize the omics advances of the SPARC gene, including the summary of SPARC gene expression associated with prognosis in pancancer and MESO, the immunosuppressive microenvironment, and cancer cell stemness. In addition, SPARC might be targeted by microRNAs. Notably, despite the controversial functions on angiogenesis, SPARC may directly or indirectly contribute to tumor angiogenesis in MESO. In conclusion, SPARC is involved in tumor invasion, metastasis, immunosuppression, cancer cell stemness, and tumor angiogenesis, eventually impacting patient survival. Strategies targeting this gene may provide novel therapeutic approaches to the treatment of MESO. Full article
(This article belongs to the Special Issue New Insights into Mesothelioma Immunotherapy)
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