Biomarkers of Ocular Allergy and Dry Eye Disease, 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 3067

Special Issue Editor

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Interests: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dry eye disease (DED) is a heterogenous disease that can present with a variety of symptoms (e.g., dryness, burning, foreign body sensation, visual fluctuations) and signs (e.g., low tear production, unstable tear film, ocular surface inflammation, epithelial disruption. Underlying this heterogeneity is a complex pathophysiology which can include both tear and nerve abnormalities. Furthermore, DED can occur as an isolated phenomenon or secondary to a systemic disorder, such as Sjögren's syndrome or graft versus host disease. Ocular allergy is likewise heterogenous, and can occur in a seasonal or perennial pattern. Its pathophysiology can involve abnormalities in soluble and/or cellular components of the immune system. Like DED, it can be isolated to the ocular surface or associated with systemic conditions such as atopic dermatitis or asthma. Given these complexities, prognostic and diagnostic biomarkers are needed for both DED and ocular allergy to identify disease contributors that can be manipulated to deliver precision therapy to patients. This Special Issue will focus on this need and include original papers and reviews that discuss the state of the art of biomarkers for these two common ocular surface disorders.

Dr. Anat Galor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular allergy
  • dry eye disease
  • Sjögren's syndrome
  • biomarker
  • prognostic biomarkers
  • diagnostic biomarkers

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

23 pages, 2373 KiB  
Review
Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies
by Merve Kulbay, Kevin Y. Wu, Gurleen K. Nirwal, Paul Bélanger and Simon D. Tran
Biomolecules 2024, 14(9), 1055; https://doi.org/10.3390/biom14091055 - 25 Aug 2024
Cited by 2 | Viewed by 2810
Abstract
This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in cataract formation and evaluates the potential of antioxidant therapies in mitigating this ocular condition. By elucidating the mechanisms of oxidative stress, the article examines how ROS contribute to the deterioration [...] Read more.
This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in cataract formation and evaluates the potential of antioxidant therapies in mitigating this ocular condition. By elucidating the mechanisms of oxidative stress, the article examines how ROS contribute to the deterioration of lens proteins and lipids, leading to the characteristic aggregation, cross-linking, and light scattering observed in cataracts. The review provides a thorough assessment of various antioxidant strategies aimed at preventing and managing cataracts, such as dietary antioxidants (i.e., vitamins C and E, lutein, and zeaxanthin), as well as pharmacological agents with antioxidative properties. Furthermore, the article explores innovative therapeutic approaches, including gene therapy and nanotechnology-based delivery systems, designed to bolster antioxidant defenses in ocular tissues. Concluding with a critical analysis of current research, the review offers evidence-based recommendations for optimizing antioxidant therapies. The current literature on the use of antioxidant therapies to prevent cataract formation is sparse. There is a lack of evidence-based conclusions; further clinical studies are needed to endorse the use of antioxidant strategies in patients to prevent cataractogenesis. However, personalized treatment plans considering individual patient factors and disease stages can be applied. This article serves as a valuable resource, providing insights into the potential of antioxidants to alleviate the burden of cataracts. Full article
(This article belongs to the Special Issue Biomarkers of Ocular Allergy and Dry Eye Disease, 2nd Edition)
Show Figures

Figure 1

Back to TopTop