Aptamer Therapeutics in Cancers: New Advances and Future Trends
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 2262
Special Issue Editors
Interests: aptamers; targeted delivery; targeted therapy; non-coding RNAs; cancer
Special Issue Information
Dear Colleagues,
Nucleic acid aptamers represent a revolutionary and winning approach in the field of precision anticancer medicine. Based on their unique three-dimensional shapes, aptamers recognize specific target molecules with high affinity, acting as selective inhibitory agents and/or carriers for targeted delivery. Therefore, aptamers allow the specific recognition of diseased tissues, strongly reducing the occurrence of undesirable off-target effects.
Due to their mode of action, they are called "chemical antibodies", but, thanks to their chemical nature, they exhibit many advantageous features over antibodies, including fast and easy production, high batch fidelity, high tissue penetration, low costs, easy chemical modification, low toxicity and immunogenicity.
To Date, many reports describe the application of aptamers or aptamer-based conjugates as anticancer drugs, also proposing multimodal approaches to improve therapeutic efficacy. Furthermore, several aptamer-based approaches have shown promise in clinical trials.
This Special Issue aims to summarize recent advances in aptamer-based technology and application in major cancer types, discussing advantages, limitations and possible improvements to optimize aptamer development in the near future.
We are pleased to invite you to participate in this Special Issue in Biomolecules by submitting an original or a review article relevant to the field.
I am looking forward to receiving your contributions.
Dr. Silvia Catuogno
Dr. Silvia Nuzzo
Guest Editors
Manuscript Submission Information
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Keywords
- aptamers
- cancer
- targeted therapy
- aptamer-based conjugates
- aptamer-conjugated nanoparticles
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