Genetics and Genomics of Heart Failure

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 3142

Special Issue Editor


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Guest Editor
Department of Advanced Biomedical Sciences, University of Naples Federico II , Naples , Italy
Interests: heart failure; hypertrophic cardiomyopathy; arterial hypertension
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Special Issue Information

Dear Colleagues, 

Heart failure (HF) poses an enormous social and economic burden worldwide. Despite the improvement in the prevention, diagnosis and management of this multifactorial syndrome, the understanding of the molecular underpinnings of HF remains incomplete. Over the course of the last several decades, molecular and genetic studies have implicated various signaling pathways participating in the pathophysiology of this syndrome. More recently, the improvement of next-generation sequencing (NGS) techniques is providing a continuously growing understanding of the genetics and genomics of cardiac cells in HF. For this Special Issue, we invite investigators to contribute original research and review articles focusing on the understanding of the molecular and genetic basis of HF and on the recently developed genomic tools applicable to HF research.

Prof. Dr. Maria Angela Losi
Guest Editor

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Keywords

  • heart failure
  • NGS, genomics
  • signaling pathways
  • genetics

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Published Papers (1 paper)

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Research

19 pages, 4278 KiB  
Article
Transcriptomal Insights of Heart Failure from Normality to Recovery
by Mohammed Quttainah, Vineesh Vimala Raveendran, Soad Saleh, Ranjit Parhar, Mansour Aljoufan, Narain Moorjani, Zohair Y. Al-Halees, Maie AlShahid, Kate S. Collison, Stephen Westaby and Futwan Al-Mohanna
Biomolecules 2022, 12(5), 731; https://doi.org/10.3390/biom12050731 - 23 May 2022
Cited by 5 | Viewed by 2495
Abstract
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more precise treatments. To attain a clearer picture of this, we studied [...] Read more.
Current management of heart failure (HF) is centred on modulating the progression of symptoms and severity of left ventricular dysfunction. However, specific understandings of genetic and molecular targets are needed for more precise treatments. To attain a clearer picture of this, we studied transcriptome changes in a chronic progressive HF model. Fifteen sheep (Ovis aries) underwent supracoronary aortic banding using an inflatable cuff. Controlled and progressive induction of pressure overload in the LV was monitored by echocardiography. Endomyocardial biopsies were collected throughout the development of LV failure (LVF) and during the stage of recovery. RNA-seq data were analysed using the PANTHER database, Metascape, and DisGeNET to annotate the gene expression for functional ontologies. Echocardiography revealed distinct clinical differences between the progressive stages of hypertrophy, dilatation, and failure. A unique set of transcript expressions in each stage was identified, despite an overlap of gene expression. The removal of pressure overload allowed the LV to recover functionally. Compared to the control stage, there were a total of 256 genes significantly changed in their expression in failure, 210 genes in hypertrophy, and 73 genes in dilatation. Gene expression in the recovery stage was comparable with the control stage with a well-noted improvement in LV function. RNA-seq revealed the expression of genes in each stage that are not reported in cardiovascular pathology. We identified genes that may be potentially involved in the aetiology of progressive stages of HF, and that may provide future targets for its management. Full article
(This article belongs to the Special Issue Genetics and Genomics of Heart Failure)
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