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Biomolecules
Special Issues
Pancreatitis and Its Complications—Call for Accurate Biomarkers
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Pancreatitis and Its Complications—Call for Accurate Biomarkers

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3443

Special Issue Editors

Dr. Paulina Dumnicka

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Guest Editor
Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
Interests: laboratory medicine; acute pancreatitis; biomarkers of inflammation; biomarkers of kidney diseases; acute kidney injury; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Beata Kusnierz-Cabala

E-Mail Website
Guest Editor
Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
Interests: laboratory medicine; acute pancreatitis; biomarkers of inflammation; biomarkers of kidney diseases; acute kidney injury; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is almost 10 years since the revision of the Atlanta classification redefined the severity of acute pancreatitis (AP) and stressed the importance of early recognition of organ failure related to systemic inflammation and vascular dysfunction. Improved fluid resuscitation and nutritional treatment in line with advancements in imaging techniques and minimally invasive surgery have significantly improved the survival rates of patients with severe AP. During the last decade, the systemic complications of AP (including cardiovascular, lung, and kidney failure) have gained research interest. Epidemiological data on prevalence and mortality rates have been collected, and our understanding of AP pathophysiology has improved, although there is still much work to be done in this field. Early diagnosis of systemic complications in AP, however, remains challenging in clinical practice.

Recently, improved understanding of the pathophysiology of chronic pancreatitis (CP) and advancements in translational research have resulted in the publication of the International Consensus Statements on Early Chronic Pancreatitis. The historical definition of the disease that required “irreversible morphological change” for the diagnosis of CP has been replaced with a mechanistic definition proposed in 2016, allowing for the diagnosis of the disease in its early, potentially reversible stage. International consensus regarding the definition of early CP has not been reached because the presently available diagnostic measures cannot reliably distinguish early CP from other pathologies with overlapping symptoms.

This Special Issue will include both basic and translational studies on biomarkers of AP and CP. Articles that advance the knowledge of early prognosis of severe AP and early diagnosis of CP are especially of interest.

Dr. Paulina Dumnicka
Prof. Dr. Beata Kusnierz-Cabala
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Acute Pancreatitis
  • Recurrent Acute Pancreatitis
  • Chronic Pancreatitis
  • Acute on Chronic Pancreatitis
  • Diagnostic Biomarkers
  • Biomarkers of Severity
  • Prognostic Biomarkers

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Published Papers (1 paper)

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Research

9 pages, 273 KiB  
Article
The Initial Course of IL1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α with Regard to Severity Grade in Acute Pancreatitis
by Hanna Sternby, Hannes Hartman, Henrik Thorlacius and Sara Regnér
Biomolecules 2021, 11(4), 591; https://doi.org/10.3390/biom11040591 - 17 Apr 2021
Cited by 25 | Viewed by 2441
Abstract
Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0–24 and 25–48 h after onsets of AP were acquired. Mean values and temporal intermediate difference [...] Read more.
Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0–24 and 25–48 h after onsets of AP were acquired. Mean values and temporal intermediate difference (delta-values) of IL-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α were calculated. Differences between severity groups, predictive capacity of the biomarkers and association with severe disease were analyzed. Paired comparison of samples (n = 115) taken at 0–24 and 25–48 h after onsets of AP showed a change over time for IL-1β, IL-6, IL-8 and IL-10 (p < 0.05) and a significant difference between severity groups after 24 h. In ROC-analysis an IL-6 cut-off level of 196.6 pg/mL could differentiate severe AP (sensitivity 81.9, specificity 91.3). The delta-values of IL-1β and IL-6 were significantly associated with severe outcomes (odds ratios 1.085 and 1.002, respectively). Data of this work demonstrate a distinct change in IL-1β, IL-8, IL-10 and IL-6 over the first 48 h after onset of AP. The temporal development of biomarkers can assist in the early stratification of the disease. Herein IL-1β and IL-6 were associated with severe disease, however the prognostic capacity of investigated biomarkers is low. Full article
(This article belongs to the Special Issue Pancreatitis and Its Complications—Call for Accurate Biomarkers)
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