Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 873

Special Issue Editors


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Guest Editor
Fraunhofer USA Center Midwest, East Lansing, MI, USA
Interests: nanomaterials; nanozymes (enzyme mimics); nano-bio interfaces; electrochemical; colorimetric; fluorometric; photothermal assays/immunoassays for point-of-care diagnostics

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Guest Editor
INL-International Iberian Nanotechnology Laboratory, Braga, Portugal
Interests: nanobioscience; diagnostics; antibody engineering; biosensor; aptamer; SELEX

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Guest Editor
Department of Biosystems Science and Engineering, ETH Zürich, Zürich, Switzerland
Interests: wearable sensor; flexible sensor; bio fuel; gas sensor; biosensor

Special Issue Information

Dear Colleagues,

The rapid development of nanotechnology has significantly advanced the field of biosensing, enabling the creation of highly sensitive and rapid diagnostic tools that are essential for point-of-care (POC) applications. This Special Issue is dedicated to exploring the latest breakthroughs in nanomaterial-enhanced biosensing technologies, with a focus on their practical applications in POC diagnostics. These advancements have the potential to revolutionize healthcare by providing timely, cost-effective, and reliable diagnostic solutions that improve patient outcomes.

Scope and Objectives:

This Special Issue aims to gather cutting-edge research and reviews on the integration of nanomaterials, such as nanoparticles, nanowires, and nanosheets, into biosensing platforms. These materials are known for their unique properties, including enhanced sensitivity, specificity, and speed in detecting biomarkers at ultra-low concentrations. The ultimate goal of this Special Issue is to showcase the current state of the art in this field and explore the potential ability of these technologies to transform POC diagnostics.

Key Topics:

Researchers and experts are invited to submit original research articles, comprehensive reviews, and case studies on a range of topics that include, but are not limited to, the following:

  • Novel Nanomaterials: The development and characterization of innovative nanomaterials for enhanced biosensing.
  • Biosensing Platforms: The integration of nanomaterials with optical, electrochemical, and microfluidic systems for enhanced diagnostics.
  • Point-Of-Care Devices: The design of portable, user-friendly diagnostic devices for real-time, on-site testing.
  • Applications: Case studies on clinical and environmental uses of nanomaterial-enhanced biosensors.
  • Challenges and Future Directions: Addressing commercialization, regulatory challenges, and comparisons with traditional diagnostics.

Aim:

This Special Issue aims to provide a comprehensive overview of the advancements in nanomaterial-enhanced biosensing and their implications for POC diagnostics. By collating the work of leading researchers and practitioners, this Special Issue seeks to foster collaboration, inspire innovative approaches, and drive the development of next-generation POC biosensors that are more sensitive, rapid, and accessible to all.

Dr. Pramod Gupta
Dr. Prabir Kumar Kulabhusan
Dr. Debasis Maity
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biosensing
  • point-of-care diagnostics
  • nanoparticles
  • microfluidics
  • clinical applications
  • electrochemical sensors
  • lab-on-a-chip
  • portable devices
  • early diagnosis

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Published Papers (1 paper)

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Research

15 pages, 3817 KiB  
Article
β-Cyclodextrin Functionalized Au@Ag Core-Shell Nanoparticles: Plasmonic Sensors for Cysteamine and Efficient Nanocatalysts for Nitrobenzene-to-Aniline Conversion
by Ramar Rajamanikandan, Kandasamy Sasikumar and Heongkyu Ju
Biosensors 2024, 14(11), 544; https://doi.org/10.3390/bios14110544 - 9 Nov 2024
Viewed by 731
Abstract
We reported the gold/silver core-shell nanoparticles (Aucore@Agshell NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Aucore@Agshell [...] Read more.
We reported the gold/silver core-shell nanoparticles (Aucore@Agshell NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Aucore@Agshell NPs, constituted a colorimetric sensing platform based on localized surface plasmons, enabling cysteamine (Cyst) to be detected in a remarkably rapid manner, i.e., within 2 min, which was greatly shortened in comparison with that of our previous report. This was due largely to use of β-CD being effectively replaceable by Cyst. The detection of Cyst was demonstrated using human urine specimens in the linear range of 25–750 nM with a limit of detection of 1.83 nM. Excellent specificity in detecting Cyst was also demonstrated against potential interfering molecules. Meanwhile, the β-CD-Aucore@Agshell NPs were demonstrated as nanocatalysts for converting NB to aniline with efficiency enhanced by more than three-fold over the pure gold nanoparticles previously reported, due to the dual functions of the structural core-shell. The demonstrated versatile features of the hybrid nanoparticles can find applications in human urine-based biosensors for Cyst detection, and in the screening of Cyst-containing drugs, while detoxicating NB for ecological protection in aqueous media. Full article
(This article belongs to the Special Issue Nanomaterial-Enhanced Biosensing for Point-of-Care Diagnostics)
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