Transistor‐Based Biosensors: From Theory to Real Devices

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 1988

Special Issue Editors


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Guest Editor
Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
Interests: biosensors; sensor design; manufacturing; characterization

E-Mail Website
Guest Editor
Institute of Chemical Biology & Fundamental Medicine, SB RAS, 8 Lavrentiev Avenue, Novosibirsk 630090, Russia
Interests: biosensor; surface functionalization; bioreceptor immobilization

Special Issue Information

Dear Colleagues,

We invite you to contribute to this Special Issue concerning  transistor‐based biosensors. Electron biosensors based on field-effect transistors (FETs) are universal, high-sensitivity, real-time, label-free platforms for biomolecular detection. First of all, these sensors are requested in the field of medical diagnostics for point‐of-care testing of various analytes (DNA, RNA, proteins, and others). Different types of transistors made of different materials To date, the development of such devices has reached the stage of commercialization. Reproducibility and stability of the sensor response are the key issues hindering their large-scale deployment/application. The increase in sensitivity is an acute issue, since most disease markers are low-copy and their content in human biofluids, especially at the early stage of diseases, is at the femto- and subfemtomolar level. The topics of this Special Issue allow you to present various approaches aimed (1) to reduce the limit of detection and increase the linear range of target detection for early diagnosis and treatment prediction of diseases, and (2) to increase the stable device performance. Topics may include, but are not limited to:

  • Target delivery of analytes to the sensor surface;
  • Minimizing non-specific adsorption;
  • Overcoming Debye length limitations for biomolecule sensing;
  • Surface functionalization and characterization;
  • Signal-enhanced methods;
  • Comparison of perfection of sensors on the basis of different materials.

Original experimental and theoretical papers and reviews are welcome.

Dr. Olga Victorovna Naumova
Dr. Elena Dmitrienko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • biosensor
  • field-effect transistor
  • sensitivity
  • detection limit
  • analyte delivery
  • functionalization
  • characterization
  • reproducibility

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Published Papers (1 paper)

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Research

14 pages, 2596 KiB  
Article
Enhanced BSA Detection Precision: Leveraging High-Performance Dual-Gate Ion-Sensitive Field-Effect-Transistor Scheme and Surface-Treated Sensing Membranes
by Yeong-Ung Kim and Won-Ju Cho
Biosensors 2024, 14(3), 141; https://doi.org/10.3390/bios14030141 - 13 Mar 2024
Cited by 1 | Viewed by 1749
Abstract
Bovine serum albumin (BSA) is commonly incorporated in vaccines to improve stability. However, owing to potential allergic reactions in humans, the World Health Organization (WHO) mandates strict adherence to a BSA limit (≤50 ng/vaccine). BSA detection with conventional techniques is time-consuming and requires [...] Read more.
Bovine serum albumin (BSA) is commonly incorporated in vaccines to improve stability. However, owing to potential allergic reactions in humans, the World Health Organization (WHO) mandates strict adherence to a BSA limit (≤50 ng/vaccine). BSA detection with conventional techniques is time-consuming and requires specialized equipment. Efficient alternatives such as the ion-sensitive field-effect transistor (ISFET), despite rapid detection, affordability, and portability, do not detect BSA at low concentrations because of inherent sensitivity limitations. This study proposes a silicon-on-insulator (SOI) substrate-based dual-gate (DG) ISFET platform to overcome these limitations. The capacitive coupling DG structure significantly enhances sensitivity without requiring external circuits, owing to its inherent amplification effect. The extended-gate (EG) structure separates the transducer unit for electrical signal processing from the sensing unit for biological detection, preventing chemical damage to the transducer, accommodating a variety of biological analytes, and affording easy replaceability. Vapor-phase surface treatment with (3-Aminopropyl) triethoxysilane (APTES) and the incorporation of a SnO2 sensing membrane ensure high BSA detection efficiency and sensitivity (144.19 mV/log [BSA]). This DG-FET-based biosensor possesses a simple structure and detects BSA at low concentrations rapidly. Envisioned as an effective on-site diagnostic tool for various analytes including BSA, this platform addresses prior limitations in biosensing and shows promise for practical applications. Full article
(This article belongs to the Special Issue Transistor‐Based Biosensors: From Theory to Real Devices)
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