Biosensors for Organ-on-Chip Devices

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1427

Special Issue Editor


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Guest Editor
Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA
Interests: organ-on-chip; lab-on-chip; biosensors; microfluidics

Special Issue Information

Dear Colleagues,

The integration of biosensors with organ-on-chip devices is revolutionizing the landscape of biomedical research and applications. These advanced platforms, which emulate the microphysiological environments of human organs, are at the forefront of drug discovery, toxicity testing, disease modeling, and personalized medicine.

Biosensors incorporated into organ-on-chip systems enable real-time, label-free monitoring of cellular and tissue-level functions, providing unprecedented insights into biological processes. The synergy between biosensor technology and organ-on-chip platforms has the potential to significantly enhance our understanding of organ-level physiology and pathology, thus paving the way for novel therapeutic strategies and more predictive models for human responses.

This Special Issue invites original research articles, comprehensive reviews, and innovative application studies that highlight the latest advancements in biosensor technology for organ-on-chip devices. We welcome contributions that cover, but are not limited to, the following topics:

  • Development and integration of novel biosensors for organ-on-chip platforms;
  • Real-time monitoring of biochemical and biophysical parameters in organ-on-chip devices;
  • Applications of organ-on-chip biosensors in drug discovery and toxicity testing;
  • Advanced microfabrication techniques and materials for biosensor and organ-on-chip integration;
  • Multiplexed biosensing and high-throughput screening using organ-on-chip systems;
  • Case studies demonstrating the clinical relevance of biosensor-integrated organ-on-chip models.

This Special Issue aims to provide a comprehensive overview of the current state of the art in this rapidly evolving field and to foster interdisciplinary collaborations that will drive future innovations. We look forward to your contributions that will help shape the future of biosensors and organ-on-chip technologies.

Dr. Danial Khorsandi
Guest Editor

Manuscript Submission Information

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Keywords

  • organ-on-chip
  • biosensors
  • microfluidics
  • real-time monitoring
  • label-free detection
  • drug discovery
  • toxicity testing
  • disease modeling
  • biochemical sensors
  • biophysical sensors
  • multiplexed biosensing

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Published Papers (1 paper)

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Research

14 pages, 3412 KiB  
Article
Impedance Characteristics of Microfluidic Channels and Integrated Coplanar Parallel Electrodes as Design Parameters for Whole-Channel Analysis in Organ-on-Chip Micro-Systems
by Crystal E. Rapier, Srikanth Jagadeesan, Gad D. Vatine and Hadar Ben-Yoav
Biosensors 2024, 14(8), 374; https://doi.org/10.3390/bios14080374 - 1 Aug 2024
Viewed by 1192
Abstract
Microfluidics have revolutionized cell culture by allowing for precise physical and chemical environmental control. Coupled with electrodes, microfluidic cell culture can be activated or have its changes sensed in real-time. We used our previously developed reliable and stable microfluidic device for cell growth [...] Read more.
Microfluidics have revolutionized cell culture by allowing for precise physical and chemical environmental control. Coupled with electrodes, microfluidic cell culture can be activated or have its changes sensed in real-time. We used our previously developed reliable and stable microfluidic device for cell growth and monitoring to design, fabricate, and characterize a whole-channel impedance-based sensor and used it to systematically assess the electrical and electrochemical influences of microfluidic channel boundaries coupled with varying electrode sizes, distances, coatings, and cell coverage. Our investigation includes both theoretical and experimental approaches to investigate how design parameters and insulating boundary conditions change impedance characteristics. We examined the system with various solutions using a frequency range of 0.5 Hz to 1 MHz and a modulation voltage of 50 mV. The results show that impedance is directly proportional to electrode distance and inversely proportional to electrode coating, area, and channel size. We also demonstrate that electrode spacing is a dominant factor contributing to impedance. In the end, we summarize all the relationships found and comment on the appropriateness of using this system to investigate barrier cells in blood vessel models and organ-on-a-chip devices. This fundamental study can help in the careful design of microfluidic culture constructs and models that require channel geometries and impedance-based biosensing. Full article
(This article belongs to the Special Issue Biosensors for Organ-on-Chip Devices)
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