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Biosensors
Special Issues
Biosensors for Monitoring and Diagnostics
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Biosensors for Monitoring and Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1983

Special Issue Editors

Prof. Dr. Radivoje Prodanović

E-Mail Website
Guest Editor
Faculty of Chemistry, University of Belgrade, Belgrade, Serbia
Interests: biocatalysis; protein engineering; biotechnology; high-throughput screening; hydrogels; biocomposites; microfluidics; biosensors; biofuel cells
Dr. Dalibor M. Stanković

E-Mail Website
Guest Editor
Faculty of Chemistry, University of Belgrade, Belgrade, Serbia
Interests: analytical chemistry; electrochemistry; development of new sensors and biosensors; materials and composites; environmental chemistry

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Biosensors for Monitoring and Diagnostics”, encompasses the critical role of biosensors in advancing healthcare practices. Specifically focusing on electrochemical sensors based on cells, proteins, and enzymes, it delves into their significance in disease monitoring and diagnosis. This compilation of research and findings explores the potential of electrochemical biosensors in enabling the rapid and accurate detection of biomarkers associated with various health conditions. This Special Issue addresses the technological advancements and innovations in the protein engineering of biological components and the design of electrochemical biosensors, highlighting their sensitivity, selectivity, and real-time monitoring capabilities. Protein engineering will cover three main strategies in designing electrochemical biosensors: de novo protein design, rational protein design, and directed evolution. The main topics will be the use of protein engineering to facilitate electron transfer and enzyme immobilization in addition to the construction of allosteric protein biosensors that should increase biosensors' sensitivity, selectivity, and stability. This Special Issue will also cover the use of artificial intelligence and bioinformatics in designing biological components of biosensors. Moreover, it delves into the integration of electrochemical biosensors with emerging technologies, such as wearable devices and point-of-care systems, to facilitate seamless and widespread deployment for monitoring and diagnosis. Overall, this Special Issue serves as a comprehensive resource for understanding the current landscape and future prospects of electrochemical biosensors in healthcare applications.

Prof. Dr. Radivoje Prodanović
Dr. Dalibor M. Stanković
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • protein engineering
  • monitoring
  • biologically active compounds
  • point of care
  • bioinformatics

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Published Papers (2 papers)

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Research

15 pages, 1539 KiB  
Article
Optimization of Paper-Based Alveolar-Mimicking SERS Sensor for High-Sensitivity Detection of Antifungal Agent
by Hyunjun Park, Kyunghwan Chai, Eugene Park, Woochang Kim, Gayoung Kim, Joohyung Park, Wonseok Lee and Jinsung Park
Biosensors 2024, 14(12), 566; https://doi.org/10.3390/bios14120566 - 22 Nov 2024
Viewed by 328
Abstract
Crystal violet (CV) is a disinfectant and antifungal agent used in aquaculture that plays a vital role in treating aquatic diseases and sterilizing water. However, its potential for strong toxicity, including carcinogenicity and mutagenicity, upon accumulation in the body raises concerns regarding its [...] Read more.
Crystal violet (CV) is a disinfectant and antifungal agent used in aquaculture that plays a vital role in treating aquatic diseases and sterilizing water. However, its potential for strong toxicity, including carcinogenicity and mutagenicity, upon accumulation in the body raises concerns regarding its safe use. Therefore, there is a growing need for the quantitative detection of CV in its early application stages to ensure human safety. Recently, Raman spectroscopy-based surface-enhanced Raman scattering (SERS) detection research has been actively conducted; consequently, an alveolar-mimicking SERS paper (AMSP) inspired by the structure of the human lungs was developed. The AMSP was optimized through various factors, including paper type, reducing agent, reducing agent concentration, and reaction time. This optimization enhanced the surface area of interaction with the target substances and promoted hotspot formation, resulting in enhanced SERS performance. The substrate exhibited exceptional uniformity, reproducibility, and reliability. CV was successfully detected at a concentration of 1 nM in laboratory settings. Furthermore, the AMSP detected CV at 1 nM in real-world environmental samples, including fish farm water and human serum, confirming its potential as a practical detection and monitoring platform for CV in real-world samples. Full article
(This article belongs to the Special Issue Biosensors for Monitoring and Diagnostics)
14 pages, 3413 KiB  
Article
Novel Multiparametric Bioelectronic Measurement System for Monitoring Virus-Induced Alterations in Functional Neuronal Networks
by Heinz-Georg Jahnke, Verena te Kamp, Christoph Prönnecke, Sabine Schmidt, Ronny Azendorf, Barbara Klupp, Andrea A. Robitzki and Stefan Finke
Biosensors 2024, 14(6), 295; https://doi.org/10.3390/bios14060295 - 5 Jun 2024
Viewed by 1128
Abstract
Development and optimisation of bioelectronic monitoring techniques like microelectrode array-based field potential measurement and impedance spectroscopy for the functional, label-free and non-invasive monitoring of in vitro neuronal networks is widely investigated in the field of biosensors. Thus, these techniques were individually used to [...] Read more.
Development and optimisation of bioelectronic monitoring techniques like microelectrode array-based field potential measurement and impedance spectroscopy for the functional, label-free and non-invasive monitoring of in vitro neuronal networks is widely investigated in the field of biosensors. Thus, these techniques were individually used to demonstrate the capabilities of, e.g., detecting compound-induced toxicity in neuronal culture models. In contrast, extended application for investigating the effects of central nervous system infecting viruses are rarely described. In this context, we wanted to analyse the effect of herpesviruses on functional neuronal networks. Therefore, we developed a unique hybrid bioelectronic monitoring platform that allows for performing field potential monitoring and impedance spectroscopy on the same microelectrode. In the first step, a neuronal culture model based on primary hippocampal cells from neonatal rats was established with reproducible and stable synchronised electrophysiological network activity after 21 days of cultivation on microelectrode arrays. For a proof of concept, the pseudorabies model virus PrV Kaplan-ΔgG-GFP was applied and the effect on the neuronal networks was monitored by impedance spectroscopy and field potential measurement for 72 h in a multiparametric mode. Analysis of several bioelectronic parameters revealed a virus concentration-dependent degeneration of the neuronal network within 24–48 h, with a significant early change in electrophysiological activity, subsequently leading to a loss of activity and network synchronicity. In conclusion, we successfully developed a microelectrode array-based hybrid bioelectronic measurement platform for quantitative monitoring of pathologic effects of a herpesvirus on electrophysiological active neuronal networks. Full article
(This article belongs to the Special Issue Biosensors for Monitoring and Diagnostics)
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