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Biosensors
Special Issues
Recent Progress in Biosensor Technologies for Detection of Exosomes
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Recent Progress in Biosensor Technologies for Detection of Exosomes

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 8550

Special Issue Editors

Prof. Dr. Nan-Fu Chiu

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Guest Editor
Laboratory of Nano-photonics and Biosensors, Institute of Electro-Optical Engineering/ Department of Life Science, National Taiwan Normal University, Applied Science Building 3F, Inst. of Elec.-Opti. Eng., No. 88, Sec. 4, Ting-Chou Road, Wenshan Dist., Taipei 11677, Taiwan
Interests: optical biosensing; plasmonics; nanophotonics; organic optoelectronic devices integrated biosensor design; BioMEMS; optical system integration; advanced 2D materials synthesis and nanofabrication; DNA biosensors; microRNA biosensors; exosome biosensors
Special Issues, Collections and Topics in MDPI journals
Dr. Yu-Sheng Hsiao

E-Mail Website
Guest Editor
Advanced Optoelectronic Polymers and Devices Laboratory, Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
Interests: liquid biopsy technology and applications; biosensors; organic electrochemical transistors (OECTs); plasmonic devices; integrated bioelectronics; Micro-RNA biosensors; exosome biosensors; PI-conjugated materials synthesis and Micro-/Nano-fabrication; Poly(3,4-ethylenedioxythiophene) (PEDOT) materials
Dr. Yun-Ju Lai

E-Mail Website
Guest Editor
School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan
Interests: cancer cell biology, signal transduction; metastasis; cancer stem cells; drug screening; nature products; programmed cell death, apoptosis; autophagy; exosome secretion; cell images; glioblastoma; colorectal carcinoma; hepatocellular carcinoma
Dr. Himansu Sekhar Nanda

E-Mail Website
Guest Editor
Biomedical Engineering and Technology Lab, Advanced Manufacturing Lab, Core Lab Complex, Discipline of Mechanical Engineering, Indian Institute of Information Technology, Design and Manufacturing Jabalpur, Dumna Airport Road, Jabalpur 482005, MP, India
Interests: microscale tissue engineering and translational bioengineering using sustainable and intelligent biomaterials; bioadhesive coatings for implants and medical devices; metal additive manufacturing for biomedical engineering; biocompatible nanostructures for angiogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am very pleased to invite you to contribute to this Special Issue on Recent Progress in Biosensor Technologies for the Detection of Exosomes. Exosomes are extracellular vesicles (generally with a length of 30-150 nm) that play important roles in various physiological and pathological processes. These cell-secreted nanoparticles are considered a special class of biomarkers for non-invasive disease diagnostics in point-of-care settings.

Biosensors have gained great research attention for the detection of exosomes due to their superior properties, such as convenient operation, real-time monitoring ability, high sensitivity, and remarkable specificity. They have great potential in various biomedical applications (from early diagnosis to therapy monitoring), e.g., the early diagnosis of cancer. Exosomes are attractive cancer biomarkers in noninvasive early diagnosis because of their unique physiological and pathological functions, which can reveal remarkable information about cancer microenvironments and plays an important role in the development and evolution of cancer.

The rapid developments of exosomes biosensors, such as concepts in structural design, fabrication techniques, sensing materials, numerical simulations, sensing techniques (optical, electrochemical, microfluidics and electrical (nano) biosensors for detection of exosomes) and diagnostic applications are significantly contributing to this field for the development of an accurate and highly sensitive detection platform for future clinical applications.

This Special Issue, entitled “Recent Progress in Biosensor Technologies for Detection of Exosomes”, will showcase the recent advances in exosomes biosensing and investigate the current challenges, recommendations and future opportunities in this field.

The editors of this Special Issue welcome original research and review articles that cover both exosome bioengineering and their biosensing applications, achieving the goal of presenting challenges in cancer biosensing and detecting trace amounts of a wide variety of analytes. This Special Issue plans not only to provide an overview of recent achievements but also to stimulate ideas about current and future research in exosome sensors in the field of translational bioengineering.

Prof. Dr. Nan-Fu Chiu
Dr. Yu-Sheng Hsiao
Dr. Yun-Ju Lai
Dr. Himansu Sekhar Nanda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exosomes
  • micro-RNA
  • biosensors
  • diagnostic applications
  • clinical applications
  • translational bioengineering

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Published Papers (2 papers)

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Review

31 pages, 7599 KiB  
Review
Advances in Nanoplasmonic Biosensors: Optimizing Performance for Exosome Detection Applications
by Devi Taufiq Nurrohman, Nan-Fu Chiu, Yu-Sheng Hsiao, Yun-Ju Lai and Himansu Sekhar Nanda
Biosensors 2024, 14(6), 307; https://doi.org/10.3390/bios14060307 - 14 Jun 2024
Viewed by 2062
Abstract
The development of sensitive and specific exosome detection tools is essential because they are believed to provide specific information that is important for early detection, screening, diagnosis, and monitoring of cancer. Among the many detection tools, surface-plasmon resonance (SPR) biosensors are analytical devices [...] Read more.
The development of sensitive and specific exosome detection tools is essential because they are believed to provide specific information that is important for early detection, screening, diagnosis, and monitoring of cancer. Among the many detection tools, surface-plasmon resonance (SPR) biosensors are analytical devices that offer advantages in sensitivity and detection speed, thereby making the sample-analysis process faster and more accurate. In addition, the penetration depth of the SPR biosensor, which is <300 nm, is comparable to the size of the exosome, making the SPR biosensor ideal for use in exosome research. On the other hand, another type of nanoplasmonic sensor, namely a localized surface-plasmon resonance (LSPR) biosensor, has a shorter penetration depth of around 6 nm. Structural optimization through the addition of supporting layers and gap control between particles is needed to strengthen the surface-plasmon field. This paper summarizes the progress of the development of SPR and LSPR biosensors for detecting exosomes. Techniques in signal amplification from two sensors will be discussed. There are three main parts to this paper. The first two parts will focus on reviewing the working principles of each sensor and introducing several methods that can be used to isolate exosomes. This article will close by explaining the various sensor systems that have been developed and the optimizations carried out to obtain sensors with better performance. To illustrate the performance improvements in each sensor system discussed, the parameters highlighted include the detection limit, dynamic range, and sensitivity. Full article
(This article belongs to the Special Issue Recent Progress in Biosensor Technologies for Detection of Exosomes)
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36 pages, 7942 KiB  
Review
Biogenesis, Isolation, and Detection of Exosomes and Their Potential in Therapeutics and Diagnostics
by Smrity Sonbhadra, Mehak and Lalit M. Pandey
Biosensors 2023, 13(8), 802; https://doi.org/10.3390/bios13080802 - 10 Aug 2023
Cited by 23 | Viewed by 5469
Abstract
The increasing research and rapid developments in the field of exosomes provide insights into their role and significance in human health. Exosomes derived from various sources, such as mesenchymal stem cells, cardiac cells, and tumor cells, to name a few, can be potential [...] Read more.
The increasing research and rapid developments in the field of exosomes provide insights into their role and significance in human health. Exosomes derived from various sources, such as mesenchymal stem cells, cardiac cells, and tumor cells, to name a few, can be potential therapeutic agents for the treatment of diseases and could also serve as biomarkers for the early detection of diseases. Cellular components of exosomes, several proteins, lipids, and miRNAs hold promise as novel biomarkers for the detection of various diseases. The structure of exosomes enables them as drug delivery vehicles. Since exosomes exhibit potential therapeutic applications, their efficient isolation from complex biological/clinical samples and precise real-time analysis becomes significant. With the advent of microfluidics, nano-biosensors are being designed to capture exosomes efficiently and rapidly. Herein, we have summarized the history, biogenesis, characteristics, functions, and applications of exosomes, along with the isolation, detection, and quantification techniques. The implications of surface modifications to enhance specificity have been outlined. The review also sheds light on the engineered nanoplatforms being developed for exosome detection and capture. Full article
(This article belongs to the Special Issue Recent Progress in Biosensor Technologies for Detection of Exosomes)
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