Advances in Electrochemical, Photonic and Optoelectronic Biosensor Technologies for Rapid Point-of-Care Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1355

Special Issue Editor


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Guest Editor
Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea
Interests: continuous physiological signal monitoring; biosensors; wireless power transfer
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Special Issue Information

Dear Colleagues,

Biosensors are innovative analytical devices that integrate biological recognition elements with electrochemical transducers to rapidly and accurately detect significant analytes. They represent a substantial leap forward in rapid detection and point-of-care diagnostics, offering numerous advantages in terms of cost-effectiveness, user-friendliness, portability, and accuracy. Moreover, their continued development, alongside advances in photonic and optoelectronic systems, promises to revolutionize healthcare and environmental monitoring by enabling more timely and precise detection of target analytes. The integration of photonic and optoelectronic technologies enhances the sensitivity, speed, and versatility of biosensors, further expanding their applications in real-time analysis. Therefore, this Special Issue highlights recent advances in the design and development of various electrochemical biosensors, as well as photonic and optoelectronic systems, and their applications in the rapid detection of significant analytes for point-of-care diagnostics. These include fundamental research, technique development, and device fabrication in the following areas.

Dr. Young-Joon Kim
Guest Editor

Manuscript Submission Information

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Keywords

  • electrochemical biosensors
  • modified electrodes
  • electrocatalysts
  • wearable sensors
  • continuous monitoring
  • flexible sensors
  • potentiometric sensors
  • amperometric sensors
  • sweat sensors
  • microneedle sensors

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Published Papers (1 paper)

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Research

11 pages, 1930 KiB  
Article
Aptamer-Mediated Electrochemical Detection of SARS-CoV-2 Nucleocapsid Protein in Saliva
by Ryan H. P. Siu, Robert G. Jesky, Yu-Jing Fan, Cyrus C. H. Au-Yeung, Andrew B. Kinghorn, Kwok-Hung Chan, Ivan Fan-Ngai Hung and Julian A. Tanner
Biosensors 2024, 14(10), 471; https://doi.org/10.3390/bios14100471 - 30 Sep 2024
Viewed by 1122
Abstract
Gold standard detection of SARS-CoV-2 by reverse transcription quantitative PCR (RT-qPCR) can achieve ultrasensitive viral detection down to a few RNA copies per sample. Yet, the lengthy detection and labor-intensive protocol limit its effectiveness in community screening. In view of this, a structural [...] Read more.
Gold standard detection of SARS-CoV-2 by reverse transcription quantitative PCR (RT-qPCR) can achieve ultrasensitive viral detection down to a few RNA copies per sample. Yet, the lengthy detection and labor-intensive protocol limit its effectiveness in community screening. In view of this, a structural switching electrochemical aptamer-based biosensor (E-AB) targeting the SARS-CoV-2 nucleocapsid (N) protein was developed. Four N protein-targeting aptamers were characterized on an electrochemical cell configuration using square wave voltammetry (SWV). The sensor was investigated in an artificial saliva matrix optimizing the aptamer anchoring orientation, SWV interrogation frequency, and target incubation time. Rapid detection of the N protein was achieved within 5 min at a low nanomolar limit of detection (LOD) with high specificity. Specific N protein detection was also achieved in simulated positive saliva samples, demonstrating its feasibility for saliva-based rapid diagnosis. Further research will incorporate novel signal amplification strategies to improve sensitivity for early diagnosis. Full article
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