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Biosensors
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Biosensors for Bioanalytical and Healthcare Applications
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Biosensors for Bioanalytical and Healthcare Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (10 September 2022) | Viewed by 31889

Special Issue Editors

Prof. Dr. Nikolaos A. Chaniotakis

E-Mail Website
Guest Editor
Department of Chemistry, University of Crete, 71003 Heraklion, Greece
Interests: development of novel technologies for sensing, detection, and energy based on electroactive and optically active nanostructures; development of direct analytical methodologies and systems based on nano materials and nanobiosytems for the monitoring of vital parameters of clinical, environmental and food interest; didactics in higher education
Prof. Dr. Paul A. Millner

E-Mail Website
Guest Editor
Professor of Bionanotechnology and Head of School, LIGHT Laboratories, School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
Interests: bionanotechnology; biosensors; electrochemistry; impedance; photo-remediation; nanoparticles; nanofibres.
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Health care awareness has generated an increased demand for direct and continuous diagnostic systems.  Biosensors and chemical sensors play a vital role in measuring and monitoring a variety of parameters, especially in implantable and wearable devices. This Special Issue is dedicated to manuscripts fousing on the fundamental requirements for the design and optimization of biosensors for the in vitro and in vivo monitoring of clinically and biologically relevant analytes. The advantages of biosensors are emphasized, with respect to the advances in nanomaterials and nano- and microfabrication techniques within the dsign and optimization process. Publications that represent the state of the art in research, engineering and manufacturing in the biosensor area for bioanalytical applications in general, and in healthcare specifically, are of interest.

Prof. Dr. Nikolaos A. Chaniotakis
Prof. Dr. Paul Millner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical sensors
  • biosensors
  • bioreceptors
  • healthcare
  • bioanalysis
  • continuous monitoring
  • nanomaterials
  • nanofabrication
  • diagnostics
  • implantable
  • wearable

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Published Papers (4 papers)

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Research

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12 pages, 2796 KiB  
Article
Glycated Hemoglobin Electrochemical Immunosensor Based on Screen-Printed Electrode
by Yuliang Zhao, Hongyu Zhang, Yang Li, Xiaoai Wang, Liang Zhao, Jianghong Xu, Zhikun Zhan, Guanglie Zhang and Wen Jung Li
Biosensors 2022, 12(10), 902; https://doi.org/10.3390/bios12100902 - 21 Oct 2022
Cited by 5 | Viewed by 3069
Abstract
An electrochemical HbA1c sensor with high sensitivity and good specificity is proposed based on the electrochemical immune principle. The reproducibility and conductivity of the electrode are improved by depositing gold nanoparticles (AuNPs) on the surface of the screen-printed electrode (SPE). The HbA1c antibodies [...] Read more.
An electrochemical HbA1c sensor with high sensitivity and good specificity is proposed based on the electrochemical immune principle. The reproducibility and conductivity of the electrode are improved by depositing gold nanoparticles (AuNPs) on the surface of the screen-printed electrode (SPE). The HbA1c antibodies are immobilized on the surface of the modified electrode by adsorption to capture the HbA1c in the sample. The hindering effect of HbA1c on the electrode transfer reaction was exploited as the HbA1c detection mechanism. The electrode’s properties were characterized by electrochemical impedance spectroscopy (EIS), and the measurement properties of the electrode were analyzed using differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The experimental results show that the peak current signal of the electrochemical immunosensor produced a linear response to HbA1c in the concentration range of 20–200 μg/mL, a linear relationship coefficient of 0.9812, a detection limit of 15.5 µg/mL, and a sensitivity of 0.0938 µA/µg·mL−1. The sensor delivered satisfactory repeatability, stability, and anti-interference performance. Due to its small size, high sensitivity, and wide linear detection range, it is expected to play a significant role in managing diabetes at home. Full article
(This article belongs to the Special Issue Biosensors for Bioanalytical and Healthcare Applications)
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20 pages, 4257 KiB  
Article
Biological Impact of γ-Fe2O3 Magnetic Nanoparticles Obtained by Laser Target Evaporation: Focus on Magnetic Biosensor Applications
by Fedor A. Fadeyev, Felix A. Blyakhman, Alexander P. Safronov, Grigory Yu. Melnikov, Anastasia D. Nikanorova, Iuliia P. Novoselova and Galina V. Kurlyandskaya
Biosensors 2022, 12(8), 627; https://doi.org/10.3390/bios12080627 - 11 Aug 2022
Cited by 7 | Viewed by 2186
Abstract
The biological activity of γ-Fe2O3 magnetic nanoparticles (MNPs), obtained by the laser target evaporation technique, was studied, with a focus on their possible use in biosensor applications. The biological effect of the MNPs was investigated in vitro on the primary [...] Read more.
The biological activity of γ-Fe2O3 magnetic nanoparticles (MNPs), obtained by the laser target evaporation technique, was studied, with a focus on their possible use in biosensor applications. The biological effect of the MNPs was investigated in vitro on the primary cultures of human dermal fibroblasts. The effects of the MNPs contained in culture medium or MNPs already uptaken by cells were evaluated for the cases of the fibroblast’s proliferation and secretion of cytokines and collagen. For the tests related to the contribution of the constant magnetic field to the biological activity of MNPs, a magnetic system for the creation of the external magnetic field (having no commercial analogues) was designed, calibrated, and used. It was adapted to the size of standard 24-well cell culture plates. At low concentrations of MNPs, uptake by fibroblasts had stimulated their proliferation. Extracellular MNPs stimulated the release of pro-inflammatory cytokines (Interleukin-6 (IL-6) and Interleukin-8 (IL-8) or chemokine (C-X-C motif) ligand 8 (CXCL8)) in a concentration-dependent manner. However, the presence of MNPs did not increase the collagen secretion. The exposure to the uniform constant magnetic field (H ≈ 630 or 320 Oe), oriented in the plane of the well, did not cause considerable changes in fibroblasts proliferation and secretion, regardless of presence of MNPs. Statistically significant differences were detected only in the levels of IL-8/CXCL8 release. Full article
(This article belongs to the Special Issue Biosensors for Bioanalytical and Healthcare Applications)
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Review

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25 pages, 8161 KiB  
Review
Biosensors and Microfluidic Biosensors: From Fabrication to Application
by Madhusudan B. Kulkarni, Narasimha H. Ayachit and Tejraj M. Aminabhavi
Biosensors 2022, 12(7), 543; https://doi.org/10.3390/bios12070543 - 20 Jul 2022
Cited by 102 | Viewed by 15592
Abstract
Biosensors are ubiquitous in a variety of disciplines, such as biochemical, electrochemical, agricultural, and biomedical areas. They can integrate various point-of-care applications, such as in the food, healthcare, environmental monitoring, water quality, forensics, drug development, and biological domains. Multiple strategies have been employed [...] Read more.
Biosensors are ubiquitous in a variety of disciplines, such as biochemical, electrochemical, agricultural, and biomedical areas. They can integrate various point-of-care applications, such as in the food, healthcare, environmental monitoring, water quality, forensics, drug development, and biological domains. Multiple strategies have been employed to develop and fabricate miniaturized biosensors, including design, optimization, characterization, and testing. In view of their interactions with high-affinity biomolecules, they find application in the sensitive detection of analytes, even in small sample volumes. Among the many developed techniques, microfluidics have been widely explored; these use fluid mechanics to operate miniaturized biosensors. The currently used commercial devices are bulky, slow in operation, expensive, and require human intervention; thus, it is difficult to automate, integrate, and miniaturize the existing conventional devices for multi-faceted applications. Microfluidic biosensors have the advantages of mobility, operational transparency, controllability, and stability with a small reaction volume for sensing. This review addresses biosensor technologies, including the design, classification, advances, and challenges in microfluidic-based biosensors. The value chain for developing miniaturized microfluidic-based biosensor devices is critically discussed, including fabrication and other associated protocols for application in various point-of-care testing applications. Full article
(This article belongs to the Special Issue Biosensors for Bioanalytical and Healthcare Applications)
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20 pages, 31598 KiB  
Review
Wearable Sensors for the Detection of Biomarkers for Wound Infection
by Alexandra Pusta, Mihaela Tertiș, Cecilia Cristea and Simona Mirel
Biosensors 2022, 12(1), 1; https://doi.org/10.3390/bios12010001 - 21 Dec 2021
Cited by 37 | Viewed by 9964
Abstract
Infection represents a major complication that can affect wound healing in any type of wound, especially in chronic ones. There are currently certain limitations to the methods that are used for establishing a clinical diagnosis of wound infection. Thus, new, rapid and easy-to-use [...] Read more.
Infection represents a major complication that can affect wound healing in any type of wound, especially in chronic ones. There are currently certain limitations to the methods that are used for establishing a clinical diagnosis of wound infection. Thus, new, rapid and easy-to-use strategies for wound infection diagnosis need to be developed. To this aim, wearable sensors for infection diagnosis have been recently developed. These sensors are incorporated into the wound dressings that are used to treat and protect the wound, and are able to detect certain biomarkers that can be correlated with the presence of wound infection. Among these biomarkers, the most commonly used ones are pH and uric acid, but a plethora of others (lactic acid, oxygenation, inflammatory mediators, bacteria metabolites or bacteria) have also been detected using wearable sensors. In this work, an overview of the main types of wearable sensors for wound infection detection will be provided. These sensors will be divided into electrochemical, colorimetric and fluorimetric sensors and the examples will be presented and discussed comparatively. Full article
(This article belongs to the Special Issue Biosensors for Bioanalytical and Healthcare Applications)
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