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Advances in Microfluidics: Transforming Detection and Quantification of Disease Biomarkers...
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Advances in Microfluidics: Transforming Detection and Quantification of Disease Biomarkers and Target Organisms

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 4279

Special Issue Editors

Dr. Hangrui Liu

E-Mail Website
Guest Editor
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
Interests: droplet; single-cell analysis; ScDNAseq; ScRNAseq; hydrogel; double emulsions
Dr. Shilun Feng

E-Mail
Guest Editor
State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China
Interests: microfluidics; droplet; deterministic lateral displacement; wearable devices; bacteria detection; on-chip imaging; POCT device
Special Issues, Collections and Topics in MDPI journals
Dr. Gaozhe Cai

E-Mail Website
Guest Editor
State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
Interests: microfluidics; biosensor; magnetic separation; foodborne pathogen; POCT device
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidic-based technologies have attracted significant research attention and have become increasingly popular in applications for bio-related detection and analysis. Over the past decade, the enhancement of microfluidics’ intrinsic features, combined with advancements in technologies like optics, electronics, sensors, and advanced material, which have been seamlessly incorporated into microfluidics, has enabled a more sensitive and specific quantification of target molecules or organisms. As a result, numerous research studies and translated platforms in biomedical microfluidics have emerged, the numbers of which keeps increasing. In this Special Issue, entitled “Advances in Microfluidics: Transforming Detection and Quantification of Disease Biomarkers and Target Organisms”, we aim to focus on further advancing biosensing and bioanalysis via microfluidic-based methods.

Original research articles or reviews related to microfluidic-based detection and quantification of disease biomarkers and target organisms are welcome. We believe that this Special Issue will serve as an invaluable platform for researchers to share their insights, exchange knowledge, and inspire further advancements in the field of microfluidic-based detection and quantification.

Dr. Hangrui Liu
Dr. Shilun Feng
Dr. Gaozhe Cai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • microfluidics
  • disease markers
  • organisms
  • sample isolation
  • limit of detection
  • signal amplification
  • sensing elements
  • advanced material
  • high throughput

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Published Papers (3 papers)

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12 pages, 4479 KiB  
Article
Capillary Flow-Based One-Minute Quantification of Amyloid Proteolysis
by Taeha Lee, Da Yeon Cheong, Kang Hyun Lee, Jae Hyun You, Jinsung Park and Gyudo Lee
Biosensors 2024, 14(8), 400; https://doi.org/10.3390/bios14080400 - 19 Aug 2024
Viewed by 1056
Abstract
Quantifying the formation and decomposition of amyloid is a crucial issue in the development of new drugs and therapies for treating amyloidosis. The current technologies for grasping amyloid formation and decomposition include fluorescence analysis using thioflavin-T, secondary structure analysis using circular dichroism, and [...] Read more.
Quantifying the formation and decomposition of amyloid is a crucial issue in the development of new drugs and therapies for treating amyloidosis. The current technologies for grasping amyloid formation and decomposition include fluorescence analysis using thioflavin-T, secondary structure analysis using circular dichroism, and image analysis using atomic force microscopy or transmission electron microscopy. These technologies typically require spectroscopic devices or expensive nanoscale imaging equipment and involve lengthy analysis, which limits the rapid screening of amyloid-degrading drugs. In this study, we introduce a technology for rapidly assessing amyloid decomposition using capillary flow-based paper (CFP). Amyloid solutions exhibit gel-like physical properties due to insoluble denatured polymers, resulting in a shorter flow distance on CFP compared to pure water. Experimental conditions were established to consistently control the flow distance based on a hen-egg-white lysozyme amyloid solution. It was confirmed that as amyloid is decomposed by trypsin, the flow distance increases on the CFP. Our method is highly useful for detecting changes in the gel properties of amyloid solutions within a minute, and we anticipate its use in the rapid, large-scale screening of anti-amyloid agents in the future. Full article
(This article belongs to the Special Issue Advances in Microfluidics: Transforming Detection and Quantification of Disease Biomarkers and Target Organisms)
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13 pages, 2847 KiB  
Article
Design and Application of Microfluidic Capture Device for Physical–Magnetic Isolation of MCF-7 Circulating Tumor Cells
by Akhilesh Bendre, Derangula Somasekhara, Varalakshmi K. Nadumane, Ganesan Sriram, Ramesh S. Bilimagga and Mahaveer D. Kurkuri
Biosensors 2024, 14(6), 308; https://doi.org/10.3390/bios14060308 - 15 Jun 2024
Viewed by 1263
Abstract
Circulating tumor cells (CTCs) are a type of cancer cell that spreads from the main tumor to the bloodstream, and they are often the most important among the various entities that can be isolated from the blood. For the diagnosis of cancer, conventional [...] Read more.
Circulating tumor cells (CTCs) are a type of cancer cell that spreads from the main tumor to the bloodstream, and they are often the most important among the various entities that can be isolated from the blood. For the diagnosis of cancer, conventional biopsies are often invasive and unreliable, whereas a liquid biopsy, which isolates the affected item from blood or lymph fluid, is a less invasive and effective diagnostic technique. Microfluidic technologies offer a suitable channel for conducting liquid biopsies, and this technology is utilized to extract CTCs in a microfluidic chip by physical and bio-affinity-based techniques. This effort uses functionalized magnetic nanoparticles (MNPs) in a unique microfluidic chip to collect CTCs using a hybrid (physical and bio-affinity-based/guided magnetic) capturing approach with a high capture rate. Accordingly, folic acid-functionalized Fe3O4 nanoparticles have been used to capture MCF-7 (breast cancer) CTCs with capture efficiencies reaching up to 95% at a 10 µL/min flow rate. Moreover, studies have been conducted to support this claim, including simulation and biomimetic investigations. Full article
(This article belongs to the Special Issue Advances in Microfluidics: Transforming Detection and Quantification of Disease Biomarkers and Target Organisms)
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13 pages, 2754 KiB  
Article
Long-Term Detection of Glycemic Glucose/Hypoglycemia by Microfluidic Sweat Monitoring Patch
by Wenjie Xu, Lei Lu, Yuxin He, Lin Cheng and Aiping Liu
Biosensors 2024, 14(6), 294; https://doi.org/10.3390/bios14060294 - 5 Jun 2024
Viewed by 1261
Abstract
A microfluidic sweat monitoring patch that collects human sweat for a long time is designed to achieve the effect of detecting the rise and fall of human sweat glucose over a long period of time by increasing the use time of a single [...] Read more.
A microfluidic sweat monitoring patch that collects human sweat for a long time is designed to achieve the effect of detecting the rise and fall of human sweat glucose over a long period of time by increasing the use time of a single patch. Five collection pools, four serpentine channels, and two different valves are provided. Among them, the three-dimensional valve has a large burst pressure as a balance between the internal and external air pressures of the patch. The bursting pressure of the two-dimensional diverter valve is smaller than that of the three-dimensional gas valve, and its role is to control the flow direction of the liquid. Through plasma hydrophilic treatment of different durations, the optimal hydrophilic duration is obtained. The embedded chromogenic disc detects the sweat glucose value at two adjacent time intervals and compares the information of the human body to increase or reduce glucose. The patch has good flexibility and can fit well with human skin, and because polydimethylsiloxane (PDMS) has good light transmission, it reduces the measurement error caused by the color-taking process and makes the detection results more accurate. Full article
(This article belongs to the Special Issue Advances in Microfluidics: Transforming Detection and Quantification of Disease Biomarkers and Target Organisms)
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