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Biosensors
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Recent Advances in Microneedle Array Electrodes in Biomedicine
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Recent Advances in Microneedle Array Electrodes in Biomedicine

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4636

Special Issue Editors

Prof. Dr. Tianyi Yan

E-Mail Website
Guest Editor
1. Key Laboratory of Convergence Medical Engineering System and Healthcare Technology, The Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing 100081, China
2. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
Interests: brain; biological microneedles; nerves
Dr. Bin Wang

E-Mail Website
Guest Editor
School of Information and Computer Science, Taiyuan University of Technology, Taiyuan, China
Interests: brain connectome; neuroimaging; complex networks; deep learning; brain computer interface
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Physiological electrical signals can directly reflect people's physical conditions and play an important role in disease diagnosis and treatment. With the emergence of various portable devices and wearable devices, the collection of physiological electrical signals has received increasing amounts of attention. In recent years, as many researchers have devoted themselves to the research of physiological electrical signal collection electrodes, microneedle array dry electrodes based on Micro Electro Mechanical Systems (MEMSs) technology have gradually matured. Microneedle array dry electrodes penetrate human skin through microneedles to achieve the continuous, long-term, and efficient collection of physiological electrical signals. Due to their low cost, simple operation, no discomfort to the subject, and high collection quality, they have gradually replaced traditional wet electrodes, thus providing an effective solution for surface biopotential recording in a safe and efficient way.

With the development of materials science, electronics, biomedical engineering, and other related fields, the development of microneedle array electrodes in the biomedical field has been accelerated. This Special Issue of Biosensors, titled “Recent Advances in Microneedle Array Electrodes in Biomedicine”, will focus on various aspects of research and development related to this field.

Prof. Dr. Tianyi Yan
Dr. Bin Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microneedle array
  • EEG
  • EMG
  • ECG
  • dry electrode
  • biopotential signal
  • acquisition
  • impedance

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Published Papers (2 papers)

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Research

21 pages, 7045 KiB  
Article
Fabrication of Multiple-Channel Electrochemical Microneedle Electrode Array via Separated Functionalization and Assembly Method
by Xin-Shuo Huang, Shuang Huang, Shan-Tao Zheng, Bao-Ming Liang, Tao Zhang, Wan Yue, Fan-Mao Liu, Peng Shi, Xi Xie and Hui-Jiuan Chen
Biosensors 2024, 14(5), 243; https://doi.org/10.3390/bios14050243 - 13 May 2024
Viewed by 1971
Abstract
Real-time monitoring of physiological indicators inside the body is pivotal for contemporary diagnostics and treatments. Implantable electrodes can not only track specific biomarkers but also facilitate therapeutic interventions. By modifying biometric components, implantable electrodes enable in situ metabolite detection in living tissues, notably [...] Read more.
Real-time monitoring of physiological indicators inside the body is pivotal for contemporary diagnostics and treatments. Implantable electrodes can not only track specific biomarkers but also facilitate therapeutic interventions. By modifying biometric components, implantable electrodes enable in situ metabolite detection in living tissues, notably beneficial in invasive glucose monitoring, which effectively alleviates the self-blood-glucose-managing burden for patients. However, the development of implantable electrochemical electrodes, especially multi-channel sensing devices, still faces challenges: (1) The complexity of direct preparation hinders functionalized or multi-parameter sensing on a small scale. (2) The fine structure of individual electrodes results in low spatial resolution for sensor functionalization. (3) There is limited conductivity due to simple device structures and weakly conductive electrode materials (such as silicon or polymers). To address these challenges, we developed multiple-channel electrochemical microneedle electrode arrays (MCEMEAs) via a separated functionalization and assembly process. Two-dimensional microneedle (2dMN)-based and one-dimensional microneedle (1dMN)-based electrodes were prepared by laser patterning, which were then modified as sensing electrodes by electrochemical deposition and glucose oxidase decoration to achieve separated functionalization and reduce mutual interference. The electrodes were then assembled into 2dMN- and 1dMN-based multi-channel electrochemical arrays (MCEAs), respectively, to avoid damaging functionalized coatings. In vitro and in vivo results demonstrated that the as-prepared MCEAs exhibit excellent transdermal capability, detection sensitivity, selectivity, and reproducibility, which was capable of real-time, in situ glucose concentration monitoring. Full article
(This article belongs to the Special Issue Recent Advances in Microneedle Array Electrodes in Biomedicine)
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18 pages, 7260 KiB  
Article
System of Implantable Electrodes for Neural Signal Acquisition and Stimulation for Wirelessly Connected Forearm Prosthesis
by Octavian Narcis Ionescu, Eduard Franti, Vlad Carbunaru, Carmen Moldovan, Silviu Dinulescu, Marian Ion, David Catalin Dragomir, Carmen Marinela Mihailescu, Ioan Lascar, Ana Maria Oproiu, Tiberiu Paul Neagu, Ruxandra Costea, Monica Dascalu, Mihai Daniel Teleanu, Gabriela Ionescu and Raluca Teleanu
Biosensors 2024, 14(1), 31; https://doi.org/10.3390/bios14010031 - 9 Jan 2024
Cited by 2 | Viewed by 2037
Abstract
There is great interest in the development of prosthetic limbs capable of complex activities that are wirelessly connected to the patient’s neural system. Although some progress has been achieved in this area, one of the main problems encountered is the selective acquisition of [...] Read more.
There is great interest in the development of prosthetic limbs capable of complex activities that are wirelessly connected to the patient’s neural system. Although some progress has been achieved in this area, one of the main problems encountered is the selective acquisition of nerve impulses and the closing of the automation loop through the selective stimulation of the sensitive branches of the patient. Large-scale research and development have achieved so-called “cuff electrodes”; however, they present a big disadvantage: they are not selective. In this article, we present the progress made in the development of an implantable system of plug neural microelectrodes that relate to the biological nerve tissue and can be used for the selective acquisition of neuronal signals and for the stimulation of specific nerve fascicles. The developed plug electrodes are also advantageous due to their small thickness, as they do not trigger nerve inflammation. In addition, the results of the conducted tests on a sous scrofa subject are presented. Full article
(This article belongs to the Special Issue Recent Advances in Microneedle Array Electrodes in Biomedicine)
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