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Biosensors
Special Issues
Nanotechnology-Based Optical Sensors for Biomedical Applications
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Nanotechnology-Based Optical Sensors for Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2868

Special Issue Editors

Dr. Giuseppe Brunetti

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Guest Editor
Optoelectronics Laboratory, Department of Electrical and Information Engineering, Polytechnic University of Bari, 70125 Bari, Italy
Interests: photonic sensors; metasurfaces; optical resonators; gyroscopes; solar cells; electronic systems; biosensors
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Caterina Ciminelli

E-Mail Website
Guest Editor
Optoelectronics Laboratory, Electrical and Information Engineering Department, Polytechnic University of Bari, Via Re David, 200, 70125 Bari, Italy
Interests: photonic sensors; metasurfaces; optical resonators; gyroscopes; solar cells; electronic systems; biosensors
Special Issues, Collections and Topics in MDPI journals
Dr. Nabarun Saha

E-Mail Website
Guest Editor
Politecnico di Bari, Bari, Italy
Interests: photonic sensors; metasurfaces; telecommunications; solar cells

Special Issue Information

Dear Colleagues,

With technological advancements, dielectric- and metal–dielectric-based hybrid metasurfaces have seen tremendous growth in light manipulation in various fields of science and technology. In recent years, these metasurfaces have become groundbreaking tools in the field of nanotechnology, offering unprecedented control of light matter interaction through subwavelength elements. They facilitate the creation of highly sensitive biosensors capable of detecting minute biomarker concentrations, which is crucial for early disease diagnosis. Additionally, metasurfaces enhance imaging systems, providing superior resolution and contrast for the detailed visualization of biological structures. These metasurfaces can be used for optical trapping and the manipulation of microscopic particles, including cells and nanoparticles. This Special Issue delves into metasurfaces presenting various theoretical and experimental results with target applications in biomedicine. Original research and review articles are welcome. The wavelength range includes, but is not limited to, visible and near-infrared light.

Dr. Giuseppe Brunetti
Prof. Dr. Caterina Ciminelli
Dr. Nabarun Saha
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nano photonics
  • dielectric metasurfaces
  • hybrid metasurfaces
  • tunable metasurfaces
  • metasurface imaging
  • surface plasmon resonance
  • biosensing
  • particle trapping

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Published Papers (2 papers)

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16 pages, 4440 KiB  
Article
High Stability and Low Power Nanometric Bio-Objects Trapping through Dielectric–Plasmonic Hybrid Nanobowtie
by Paola Colapietro, Giuseppe Brunetti, Annarita di Toma, Francesco Ferrara, Maria Serena Chiriacò and Caterina Ciminelli
Biosensors 2024, 14(8), 390; https://doi.org/10.3390/bios14080390 - 13 Aug 2024
Viewed by 1188
Abstract
Micro and nano-scale manipulation of living matter is crucial in biomedical applications for diagnostics and pharmaceuticals, facilitating disease study, drug assessment, and biomarker identification. Despite advancements, trapping biological nanoparticles remains challenging. Nanotweezer-based strategies, including dielectric and plasmonic configurations, show promise due to their [...] Read more.
Micro and nano-scale manipulation of living matter is crucial in biomedical applications for diagnostics and pharmaceuticals, facilitating disease study, drug assessment, and biomarker identification. Despite advancements, trapping biological nanoparticles remains challenging. Nanotweezer-based strategies, including dielectric and plasmonic configurations, show promise due to their efficiency and stability, minimizing damage without direct contact. Our study uniquely proposes an inverted hybrid dielectric–plasmonic nanobowtie designed to overcome the primary limitations of existing dielectric–plasmonic systems, such as high costs and manufacturing complexity. This novel configuration offers significant advantages for the stable and long-term trapping of biological objects, including strong energy confinement with reduced thermal effects. The metal’s efficient light reflection capability results in a significant increase in energy field confinement (EC) within the trapping site, achieving an enhancement of over 90% compared to the value obtained with the dielectric nanobowtie. Numerical simulations confirm the successful trapping of 100 nm viruses, demonstrating a trapping stability greater than 10 and a stiffness of 2.203 fN/nm. This configuration ensures optical forces of approximately 2.96 fN with an input power density of 10 mW/μm2 while preserving the temperature, chemical–biological properties, and shape of the biological sample. Full article
(This article belongs to the Special Issue Nanotechnology-Based Optical Sensors for Biomedical Applications)
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19 pages, 5501 KiB  
Article
Detecting Nanotopography Induced Changes in Cell Migration Directions Using Oxygen Sensors
by Muting Wang and Stella W. Pang
Biosensors 2024, 14(8), 389; https://doi.org/10.3390/bios14080389 - 12 Aug 2024
Viewed by 1376
Abstract
This study investigates the oxygen (O2) consumption of single cells during changes in their migration direction. This is the first integration of nanotopographies with an O2 biosensor in a platform, allowing the real-time monitoring of O2 consumption in cells [...] Read more.
This study investigates the oxygen (O2) consumption of single cells during changes in their migration direction. This is the first integration of nanotopographies with an O2 biosensor in a platform, allowing the real-time monitoring of O2 consumption in cells and the ability to distinguish cells migrating in the same direction from those migrating in the opposite direction. Advanced nanofabrication technologies were used to pattern nanoholes or nanopillars on grating ridges, and their effects were evaluated using fluorescence microscopy, cell migration assays, and O2 consumption analysis. The results revealed that cells on the nanopillars over grating ridges exhibited an enhanced migration motility and more frequent directional changes. Additionally, these cells showed an increased number of protrusions and filopodia with denser F-actin areas and an increased number of dotted F-actin structures around the nanopillars. Dynamic metabolic responses were also evident, as indicated by the fluorescence intensity peaks of platinum octaethylporphyrin ketone dye, reflecting an increased O2 consumption and higher mitochondria activities, due to the higher energy required in response to directional changes. The study emphasizes the complex interplay between O2 consumption and cell migration directional changes, providing insights into biomaterial science and regenerative medicine. It suggests innovative designs for biomaterials that guide cell migration and metabolism, advocating nanoengineered platforms to harness the intricate relationships between cells and their microenvironments for therapeutic applications. Full article
(This article belongs to the Special Issue Nanotechnology-Based Optical Sensors for Biomedical Applications)
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