Advanced Nanomaterials for Bio-Imaging

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (30 May 2024) | Viewed by 6386

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Department of Chemistry, University of Colorado Denver, Campus Box 194, P.O. Box 173364, Denver, CO 80217, USA
Interests: theranostic imaging; biosensors; nanoprobes; optical imaging; fluorescence guided surgery; molecular recognition
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Dear Colleagues,

Recent advanced nanomaterials have served as an excellent platform for optical imaging biosensors to improve cancer detection, diagnosis, and image guided surgery while reducing the exposure of patients to harmful radiation caused by other traditional molecular imaging methods (e.g., X-ray, MRI, PET, SPECT, etc.). Optical imaging is amenable to high throughput analyses because images can be acquired in a few seconds, and multiple subjects can be imaged simultaneously; thus, the method can be used for lengthy and repeated procedures over time, to monitor the progression of disease or the results of treatment. Optical imaging is also highly sensitive and cost effective, and it is straightforward to use. Importantly, a single nanomaterial can incorporate various imaging agents and target ligands followed by bioconjugation on the surface or encapsulation of molecules. Thus, rationally designed nanomaterials possess multimodality in imaging with minimal side effects to adjacent tissues and organs. Therefore, recent advances in bio-nano-imaging have laid the groundwork for vibrant new interdisciplinary research. We look forward to receiving contributions in these research areas that push the boundaries of this exciting new field.

Dr. Jung-Jae Lee
Guest Editor

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Keywords

  • molecular-targeted imaging for cancer
  • multimodal nanoparticlulate bioimaging
  • molecular imaging (MRI, CT, optical imaging, etc.)
  • enhanced permeability and retention effect of nanoparticles
  • nanoparticle characterization
  • cancer cell targeting and detection

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Published Papers (2 papers)

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Research

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11 pages, 1892 KiB  
Article
Super-Long SERS Active Single Silver Nanowires for Molecular Imaging in 2D and 3D Cell Culture Models
by Xiao-Tong Pan, Xuan-Ye Yang, Tian-Qi Mao, Kang Liu, Zao-Zao Chen, Li-Na Ji, De-Chen Jiang, Kang Wang, Zhong-Ze Gu and Xing-Hua Xia
Biosensors 2022, 12(10), 875; https://doi.org/10.3390/bios12100875 - 15 Oct 2022
Cited by 5 | Viewed by 2315
Abstract
Establishing a systematic molecular information analysis strategy for cell culture models is of great significance for drug development and tissue engineering technologies. Here, we fabricated single silver nanowires with high surface-enhanced Raman scattering activity to extract SERS spectra in situ from two-dimensional (2D) [...] Read more.
Establishing a systematic molecular information analysis strategy for cell culture models is of great significance for drug development and tissue engineering technologies. Here, we fabricated single silver nanowires with high surface-enhanced Raman scattering activity to extract SERS spectra in situ from two-dimensional (2D) and three-dimensional (3D) cell culture models. The silver nanowires were super long, flexible and thin enough to penetrate through multiple cells. A single silver nanowire was used in combination with a four-dimensional microcontroller as a cell endoscope for spectrally analyzing the components in cell culture models. Then, we adopted a machine learning algorithm to analyze the obtained spectra. Our results show that the abundance of proteins differs significantly between the 2D and 3D models, and that nucleic acid-rich and protein-rich regions can be distinguished with satisfactory accuracy. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Bio-Imaging)
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Review

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17 pages, 1951 KiB  
Review
Intravascular Imaging of Atherosclerosis by Using Engineered Nanoparticles
by Jiawen Li, Franco Centurion, Rouyan Chen and Zi Gu
Biosensors 2023, 13(3), 319; https://doi.org/10.3390/bios13030319 - 24 Feb 2023
Cited by 6 | Viewed by 3242
Abstract
Atherosclerosis is a leading cause of morbidity and mortality, and high-risk atherosclerotic plaques can result in myocardial infarction, stroke, and/or sudden death. Various imaging and sensing techniques (e.g., ultrasound, optical coherence tomography, fluorescence, photoacoustic) have been developed for scanning inside blood vessels to [...] Read more.
Atherosclerosis is a leading cause of morbidity and mortality, and high-risk atherosclerotic plaques can result in myocardial infarction, stroke, and/or sudden death. Various imaging and sensing techniques (e.g., ultrasound, optical coherence tomography, fluorescence, photoacoustic) have been developed for scanning inside blood vessels to provide accurate detection of high-risk atherosclerotic plaques. Nanoparticles have been utilized in intravascular imaging to enable targeted detection of high-risk plaques, to enhance image contrast, and in some applications to also provide therapeutic functions of atherosclerosis. In this paper, we review the recent progress on developing nanoparticles for intravascular imaging of atherosclerosis. We discuss the basic nanoparticle design principles, imaging modalities and instrumentations, and common targets for atherosclerosis. The review is concluded and highlighted with discussions on challenges and opportunities for bringing nanoparticles into in vivo (pre)clinical intravascular applications. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Bio-Imaging)
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