Bioelectric Impedance Technology for Next Generation Point-of-Care Biomedical Biomarkers and Diagnostics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3715

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Guest Editor
School of Food, Biotechnology and Development (TBA), Agricultural University of Athens, 11855 Athens, Greece
Interests: biosensors; pharmaceuticals; point-of-care systems
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Special Issue Information

Dear Colleagues,

Point-of-care devices are unique diagnostic technologies that provide the potential for rapid biomarker detection and monitoring of medical conditions, thereby bypassing the demand for high-cost clinical laboratory facilities in many cases. Bioelectric sensors are suitable for use in handheld diagnostic devices due to the integrated electronic detection instrumentation and low requirement for processing reagents. Nowadays, bioelectric impedance sensing is widely used in tissue analysis such as body composition monitoring, however, its use in point-of-care patient testing is yet to be widely adopted.

Bioelectric signals correspond to an important set of cell growth and proliferation regulation mechanisms. Μore and more findings suggest the existence of specific cell-associated impedance patterns as a means of each cell response to a specific set of current frequencies and the alterations between normal and pathological cell-specific frequency levels. As more powerful, yet feasible and often portable instrumentation becomes commercially available, bioimpedance spectroscopy is gradually becoming a favorable tool for non-invasive, reagentless monitoring of cell physiology in response to a literally inexhaustible array of environmental stimular and experimental treatments. At the same time, bioelectric profiling is being rapidly established as a biocompatible, affordable and miniaturized tool for a number of applications, including in vitro toxicity, signal transduction, real-time medical diagnostics, as wells as hallmark for early detection of diseases.

The aim of this Special Issue is to focus on the most recent advances and developments of biosensors in the field of bioelectric impedance sensing. Suggested topics are bioelectric sensors for single cell analysis, impedimetric biosensors, wireless biological electronic sensors, and implantable autonomous bioelectric micro- and nano-sensors. In addition, approaches providing a point-of-care/portable and wireless instrumentation, high throughput analytical capacity, and intelligent bioelectric impedance sensing platforms are also welcome.

Research papers, short communications, and reviews are all welcome.

Prof. Dr. Spyridon Kintzios
Dr. Sofia Mavrikou
Guest Editors

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Keywords

  • Bioelectric
  • Bioelectric profiling
  • Biosensor
  • Cell-based biosensors
  • Organ-on-a-Chip
  • Differentiation
  • Morphogenesis
  • Pharmacology research
  • Impedimetric
  • Impedance spectrometry
  • Implantable
  • Medical diagnostics
  • Βioanalysis
  • Single cell analysis
  • Biomarker
  • Toxicology

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Published Papers (1 paper)

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Research

15 pages, 3764 KiB  
Article
Evaluation of Cancer Cell Lines by Four-Point Probe Technique, by Impedance Measurements in Various Frequencies
by Georgia Paivana, Dimitris Barmpakos, Sophie Mavrikou, Alexandros Kallergis, Odysseus Tsakiridis, Grigoris Kaltsas and Spyridon Kintzios
Biosensors 2021, 11(9), 345; https://doi.org/10.3390/bios11090345 - 18 Sep 2021
Cited by 4 | Viewed by 2739
Abstract
Cell-based biosensors appear to be an attractive tool for the rapid, simple, and cheap monitoring of chemotherapy effects at a very early stage. In this study, electrochemical measurements using a four-point probe method were evaluated for suspensions of four cancer cell lines of [...] Read more.
Cell-based biosensors appear to be an attractive tool for the rapid, simple, and cheap monitoring of chemotherapy effects at a very early stage. In this study, electrochemical measurements using a four-point probe method were evaluated for suspensions of four cancer cell lines of different tissue origins: SK–N–SH, HeLa, MCF-7 and MDA-MB-231, all for two different population densities: 50 K and 100 K cells/500 μL. The anticancer agent doxorubicin was applied for each cell type in order to investigate whether the proposed technique was able to determine specific differences in cell responses before and after drug treatment. The proposed methodology can offer valuable insight into the frequency-dependent bioelectrical responses of various cellular systems using a low frequency range and without necessitating lengthy cell culture treatment. The further development of this biosensor assembly with the integration of specially designed cell/electronic interfaces can lead to novel diagnostic biosensors and therapeutic bioelectronics. Full article
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