Biosensors Based on Nanoscale Components and Devices

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 5328

Special Issue Editor

Special Issue Information

Dear Colleagues,

Biosensors have been widely applied in many fields, namely, the food industry, medical science, in the field of pharmacy or the marine sector, etc. In the last 10–15 years, several types of biosensors such as enzyme- or tissue-based, DNA biosensors, immunosensors, thermal, piezoelectric or optical biosensors have been designed, where in many cases nanostructured materials have been used as a “building blocks”. Today, nanostructured materials play an important role in a wide range of fields, including but not limited to chemistry, physics, medicine, catalytic processes, food processing industries, electronics, energy sectors, optoelectronics, and sensing.

This Special Issue of Biosensors aims to publish original high-quality research papers covering the most recent advances as well as comprehensive reviews addressing state-of-the-art topics in the field of mainly plasmonic- or fluorescent-based sensors using nano- or sub-nanometer-sized noble metals (gold, silver or copper). Moreover, this Special Issue also focuses on the presentation of the design of surface plasmon resonance (SPR) spectroscopy-based sensors and nanostructure-based surface-enhanced Raman scattering biosensors.

Preferred topics:

  • Design of nanosized plasmonic metal-based biosensors;
  • Design of nanosized fluorescent metal-based biosensors;
  • Fabrication of surface-enhanced Raman scattering biosensors;
  • Application of surface plasmon resonance (SPR) spectroscopy for selective detection of biological “objects” (cells, bacteria, viruses, etc.).

In advance, I would like to gratefully acknowledge the authors and reviewers who will participate to this Special Issue and that will contribute to the development of research based on the use of novel plasmonic and fluorescent biosensors.

Dr. Edit Csapó
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plasmonic biosensors
  • fluorescent biosensors
  • nanostructured noble metals
  • SPR
  • surface-enhanced Raman scattering

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Published Papers (1 paper)

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Research

13 pages, 3117 KiB  
Article
Development of Surface-Enhanced Raman Scattering (SERS)-Based Surface-Corrugated Nanopillars for Biomolecular Detection of Colorectal Cancer
by Kuan-Hung Chen, Meng-Ju Pan, Zoljargal Jargalsaikhan, Tseren-Onolt Ishdorj and Fan-Gang Tseng
Biosensors 2020, 10(11), 163; https://doi.org/10.3390/bios10110163 - 31 Oct 2020
Cited by 37 | Viewed by 4737
Abstract
In this paper, a nanobiosensor with surface-enhanced Raman scattering (SERS) capability is introduced for highly sensitive miRNA detection in colorectal cancer. This sensor was designed and fabricated by employing a nanoshielding mechanism from nanopolystyrene beads to resist reactive ion etching and allow anisotropic [...] Read more.
In this paper, a nanobiosensor with surface-enhanced Raman scattering (SERS) capability is introduced for highly sensitive miRNA detection in colorectal cancer. This sensor was designed and fabricated by employing a nanoshielding mechanism from nanopolystyrene beads to resist reactive ion etching and allow anisotropic electrochemical etching, producing high-aspect-ratio, surface-corrugated nanopillars (SiNPs) on a silicon wafer to create extensive hot spots along the nanopillars for improved SERS signals. SERS enhancements were correlated with nanorange roughness, indicating that hot spots along the pillars were the crucial factor to improve the SERS effect. We achieved the detection capability of a trace amount of R6G (10−8 M), and the SERS signal enhancement factor (EF) was close to 1.0 × 107 on surface-corrugated gold SiNPs. miRNA samples were also demonstrated on this sensor with good sensitivity and specificity. The target molecule miR-21-Cy5 was easily monitored through Raman spectrum variation with a PCR-comparable concentration at around 100 pM with clear nucleotide-specific Raman signals, which is also suitable for biomolecule sensing. Full article
(This article belongs to the Special Issue Biosensors Based on Nanoscale Components and Devices)
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