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Biosensors
Special Issues
Nanophotonics and Plasmonics for SARS-CoV-2 Biosensing
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Nanophotonics and Plasmonics for SARS-CoV-2 Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 9618

Special Issue Editors

Prof. Dr. Andrey Sarychev

E-Mail Website
Guest Editor
Institute for Theoretical and Applied Electrodynamics, Russian Academy of Sciences, Moscow 125412, Russia
Interests: plasmonics; nanophotonics; sensors; SERS
Prof. Dr. Grégory Barbillon

E-Mail Website
Guest Editor
EPF-Ecole d'Ingénieurs (Graduate School of Engineering), 55 Avenue du Président Wilson, 94230 Cachan, France
Interests: plasmonics; nano-optics; non-linear optics; nanophotonics; condensed matter physics; optical sensing; biosensing; nanotechnology; surface-enhanced spectroscopies; sum-frequency generation spectroscopy; materials chemistry; physical chemistry; fluorescence
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ilya Kurochkin

E-Mail Website
Guest Editor
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow 119334, Russia
Interests: biotechnology; polymer composites; biophotonics; sensors

Special Issue Information

Dear Colleagues,

SARS-CoV-2 is responsible for the ongoing outbreak of atypical pneumonia (COVID-2019) that has affected nearly 490 million people and killed over 6 million in more than 220 countries. The development of a highly sensitive and specific spectral method for the rapid detection of viruses, particularly SARS-CoV-2 strains, could reduce both the time and cost of detection, ensure earlier diagnosis, and save many lives. We are soliciting papers on nanomaterial-based surface-enhanced Raman scattering (SERS) spectroscopy, which has the capability for very low-level fingerprint identification of virus, antigen, and antibody via metasurfaces, plasmonic nanoparticles, and heterostructure material. Papers devoted to any other spectroscopes and photonic methods of SARS-CoV-2 sensing are most welcome.

Prof. Dr. Andrey Sarychev
Prof. Dr. Grégory Barbillon
Prof. Dr. Ilya Kurochkin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • SARS-CoV-2
  • nanomaterial
  • SERS
  • fluorescence
  • spike protein
  • plasmonic nanostructures
  • aptasensor

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Published Papers (3 papers)

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Research

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15 pages, 5445 KiB  
Article
Development of a Single-Chain Variable Fragment of CR3022 for a Plasmonic-Based Biosensor Targeting the SARS-CoV-2 Spike Protein
by Taufik Ramdani Tohari, Isa Anshori, Umi Baroroh, Antonius Eko Nugroho, Gilang Gumilar, Shinta Kusumawardani, Sari Syahruni, Brian Yuliarto, Wyanda Arnafia, Irvan Faizal, Yeni Wahyuni Hartati, Toto Subroto and Muhammad Yusuf
Biosensors 2022, 12(12), 1133; https://doi.org/10.3390/bios12121133 - 6 Dec 2022
Cited by 4 | Viewed by 2465
Abstract
Two years after SARS-CoV-2 caused the first case of COVID-19, we are now in the “new normal” period, where people’s activity has bounced back, followed by the easing of travel policy restrictions. The lesson learned is that the wide availability of accurate and [...] Read more.
Two years after SARS-CoV-2 caused the first case of COVID-19, we are now in the “new normal” period, where people’s activity has bounced back, followed by the easing of travel policy restrictions. The lesson learned is that the wide availability of accurate and rapid testing procedures is crucial to overcome possible outbreaks in the future. Therefore, many laboratories worldwide have been racing to develop a new point-of-care diagnostic test. To aid continuous innovation, we developed a plasmonic-based biosensor designed explicitly for portable Surface Plasmon Resonance (SPR). In this study, we designed a single chain variable fragment (scFv) from the CR3022 antibody with a particular linker that inserted a cysteine residue at the second position. It caused the linker to have a strong affinity to the gold surface through thiol-coupling and possibly become a ready-to-use bioreceptor toward a portable SPR gold chip without purification steps. The theoretical affinity of this scFv on spike protein was −64.7 kcal/mol, computed using the Molecular Mechanics Generalized Born Surface Area (MM/GBSA) method from the 100 ns molecular dynamics trajectory. Furthermore, the scFv was produced in Escherichia coli BL21 (DE3) as a soluble protein. The binding activity toward Spike Receptor Binding Domain (RBD) SARS-CoV-2 was confirmed with a spot-test, and the experimental binding free energy of −10.82 kcal/mol was determined using portable SPR spectroscopy. We hope this study will be useful in designing specific and low-cost bioreceptors, particularly early in an outbreak when the information on antibody capture is still limited. Full article
(This article belongs to the Special Issue Nanophotonics and Plasmonics for SARS-CoV-2 Biosensing)
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Review

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36 pages, 3026 KiB  
Review
Hierarchical Nanobiosensors at the End of the SARS-CoV-2 Pandemic
by Jael Abigail Medrano-Lopez, Isaela Villalpando, Ma Isabel Salazar and Carlos Torres-Torres
Biosensors 2024, 14(2), 108; https://doi.org/10.3390/bios14020108 - 18 Feb 2024
Cited by 5 | Viewed by 2087
Abstract
Nanostructures have played a key role in the development of different techniques to attack severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some applications include masks, vaccines, and biosensors. The latter are of great interest for detecting diseases since some of their features allowed [...] Read more.
Nanostructures have played a key role in the development of different techniques to attack severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some applications include masks, vaccines, and biosensors. The latter are of great interest for detecting diseases since some of their features allowed us to find specific markers in secretion samples such as saliva, blood, and even tears. Herein, we highlight how hierarchical nanoparticles integrated into two or more low-dimensional materials present outstanding advantages that are attractive for photonic biosensing using their nanoscale functions. The potential of nanohybrids with their superlative mechanical characteristics together with their optical and optoelectronic properties is discussed. The progress in the scientific research focused on using nanoparticles for biosensing a variety of viruses has become a medical milestone in recent years, and has laid the groundwork for future disease treatments. This perspective analyzes the crucial information about the use of hierarchical nanostructures in biosensing for the prevention, treatment, and mitigation of SARS-CoV-2 effects. Full article
(This article belongs to the Special Issue Nanophotonics and Plasmonics for SARS-CoV-2 Biosensing)
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27 pages, 15218 KiB  
Review
Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2
by Meimei Xu, Yanyan Li, Chenglong Lin, Yusi Peng, Shuai Zhao, Xiao Yang and Yong Yang
Biosensors 2022, 12(10), 862; https://doi.org/10.3390/bios12100862 - 12 Oct 2022
Cited by 19 | Viewed by 4116
Abstract
The outbreak of Corona Virus Disease 2019 (COVID-19) has again emphasized the significance of developing rapid and highly sensitive testing tools for quickly identifying infected patients. Although the current reverse transcription polymerase chain reaction (RT-PCR) diagnostic techniques can satisfy the required sensitivity and [...] Read more.
The outbreak of Corona Virus Disease 2019 (COVID-19) has again emphasized the significance of developing rapid and highly sensitive testing tools for quickly identifying infected patients. Although the current reverse transcription polymerase chain reaction (RT-PCR) diagnostic techniques can satisfy the required sensitivity and specificity, the inherent disadvantages with time-consuming, sophisticated equipment and professional operators limit its application scopes. Compared with traditional detection techniques, optical biosensors based on nanomaterials/nanostructures have received much interest in the detection of SARS-CoV-2 due to the high sensitivity, high accuracy, and fast response. In this review, the research progress on optical biosensors in SARS-CoV-2 diagnosis, including fluorescence biosensors, colorimetric biosensors, Surface Enhancement Raman Scattering (SERS) biosensors, and Surface Plasmon Resonance (SPR) biosensors, was comprehensively summarized. Further, promising strategies to improve optical biosensors are also explained. Optical biosensors can not only realize the rapid detection of SARS-CoV-2 but also be applied to judge the infectiousness of the virus and guide the choice of SARS-CoV-2 vaccines, showing enormous potential to become point-of-care detection tools for the timely control of the pandemic. Full article
(This article belongs to the Special Issue Nanophotonics and Plasmonics for SARS-CoV-2 Biosensing)
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