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Biosensors
Special Issues
Organ-on-a-Chip for Biosensing
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Organ-on-a-Chip for Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 27527

Special Issue Editors

Dr. Hon Fai Chan

E-Mail Website
Guest Editor
Institute for Tissue Engineering and Regenerative Medicine, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Interests: tissue engineering; stem cells; biomaterials; microfluidics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sriram Gopu

E-Mail Website
Guest Editor
Faculty of Dentistry, National University of Singapore, Singapore 119085, Singapore
Interests: tissue engineering; bioengineering; microfluidics; organ-on-a-chip; lab-on-a-chip; 3D bio-printing; stem cell; biomaterials

Special Issue Information

Dear Colleagues,

An organ-on-a-chip is a microfluidic cell culture device that simulates tissue- and organ-level physiology. By recreating an in vivo-like, physiological-relevant microenvironment, the device has great potential to overcome the limitations of conventional 2D or 3D culture systems. This technology can be applied to areas such as studying organ/tissue physiology, understanding disease etiology, and facilitating drug development. One of the important aspects of organ-on-a-chip is the integration and application of sensing technologies to provide reliable, high-content information on the physiological response of the device. To enable in situ continual monitoring of organ behaviors, a variety of biosensors have been integrated to detect organ-specific reactions and dynamic tissue responses. This Special Issue aims to focus on the recent development of biosensing strategies applied to organ-on-a-chip research.

Prof. Dr. Hon Fai Chan
Prof. Dr. Sriram Gopu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organ-on-a-chip
  • microfluidics
  • biosensor
  • organoid
  • 3D culture

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Published Papers (4 papers)

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Research

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13 pages, 3704 KiB  
Article
Design and Fabrication of the Vertical-Flow Bioreactor for Compaction Hepatocyte Culture in Drug Testing Application
by Liang Zhu, Zhenfeng Wang, Huanming Xia and Hanry Yu
Biosensors 2021, 11(5), 160; https://doi.org/10.3390/bios11050160 - 19 May 2021
Cited by 2 | Viewed by 3096
Abstract
The perfusion culture of primary hepatocytes has been widely adopted to build bioreactors for various applications. As a drug testing platform, a unique vertical-flow bioreactor (VfB) array was found to create the compaction culture of hepatocytes which mimicked the mechanic microenvironment in vivo [...] Read more.
The perfusion culture of primary hepatocytes has been widely adopted to build bioreactors for various applications. As a drug testing platform, a unique vertical-flow bioreactor (VfB) array was found to create the compaction culture of hepatocytes which mimicked the mechanic microenvironment in vivo while maintaining the 3D cell morphology in a 2D culture setup and enhancing the hepatic functions for a sustained culture. Here, we report the methodology in designing and fabricating the VfB to reach ideal bioreactor requirements, optimizing the VfB as a prototype for drug testing, and to demonstrate the enhanced hepatic function so as to demonstrate the performance of the bioreactor. This device enables the modular, scalable, and manufacturable construction of a functional drug testing platform through the sustained maintenance of model cells. Full article
(This article belongs to the Special Issue Organ-on-a-Chip for Biosensing)
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Review

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35 pages, 6609 KiB  
Review
Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
by Erika Ferrari, Cecilia Palma, Simone Vesentini, Paola Occhetta and Marco Rasponi
Biosensors 2020, 10(9), 110; https://doi.org/10.3390/bios10090110 - 28 Aug 2020
Cited by 82 | Viewed by 9340
Abstract
Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular environments, they represent promising tools for tissue engineering [...] Read more.
Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular environments, they represent promising tools for tissue engineering and drug screening applications. The achievement of proper functionalities within OoC is crucial; to this purpose, several parameters (e.g., chemical, physical) need to be assessed. Currently, most approaches rely on off-chip analysis and imaging techniques. However, the urgent demand for continuous, noninvasive, and real-time monitoring of tissue constructs requires the direct integration of biosensors. In this review, we focus on recent strategies to miniaturize and embed biosensing systems into organs-on-chip platforms. Biosensors for monitoring biological models with metabolic activities, models with tissue barrier functions, as well as models with electromechanical properties will be described and critically evaluated. In addition, multisensor integration within multiorgan platforms will be further reviewed and discussed. Full article
(This article belongs to the Special Issue Organ-on-a-Chip for Biosensing)
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22 pages, 4619 KiB  
Review
The Current Trends of Biosensors in Tissue Engineering
by Yi-Chen Ethan Li and I-Chi Lee
Biosensors 2020, 10(8), 88; https://doi.org/10.3390/bios10080088 - 3 Aug 2020
Cited by 50 | Viewed by 10122
Abstract
Biosensors constitute selective, sensitive, and rapid tools for disease diagnosis in tissue engineering applications. Compared to standard enzyme-linked immunosorbent assay (ELISA) analytical technology, biosensors provide a strategy to real-time and on-site monitor micro biophysiological signals via a combination of biological, chemical, and physical [...] Read more.
Biosensors constitute selective, sensitive, and rapid tools for disease diagnosis in tissue engineering applications. Compared to standard enzyme-linked immunosorbent assay (ELISA) analytical technology, biosensors provide a strategy to real-time and on-site monitor micro biophysiological signals via a combination of biological, chemical, and physical technologies. This review summarizes the recent and significant advances made in various biosensor technologies for different applications of biological and biomedical interest, especially on tissue engineering applications. Different fabrication techniques utilized for tissue engineering purposes, such as computer numeric control (CNC), photolithographic, casting, and 3D printing technologies are also discussed. Key developments in the cell/tissue-based biosensors, biomolecular sensing strategies, and the expansion of several biochip approaches such as organs-on-chips, paper based-biochips, and flexible biosensors are available. Cell polarity and cell behaviors such as proliferation, differentiation, stimulation response, and metabolism detection are included. Biosensors for diagnosing tissue disease modes such as brain, heart, lung, and liver systems and for bioimaging are discussed. Finally, we discuss the challenges faced by current biosensing techniques and highlight future prospects of biosensors for tissue engineering applications. Full article
(This article belongs to the Special Issue Organ-on-a-Chip for Biosensing)
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Other

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16 pages, 2556 KiB  
Perspective
Emerging Biosensors for Oral Cancer Detection and Diagnosis—A Review Unravelling Their Role in Past and Present Advancements in the Field of Early Diagnosis
by Vidhya Rekha Umapathy, Prabhu Manickam Natarajan, Bhuminathan Swamikannu, Johnson Moses, Sumathi Jones, Manoj Prathap Chandran and Madurai Kannan Anbumozhi
Biosensors 2022, 12(7), 498; https://doi.org/10.3390/bios12070498 - 8 Jul 2022
Cited by 20 | Viewed by 3489
Abstract
Oral cancer is a serious concern to people all over the world because of its high mortality rate and metastatic spread to other areas of the body. Despite recent advancements in biomedical research, OC detection at an early stage remains a challenge and [...] Read more.
Oral cancer is a serious concern to people all over the world because of its high mortality rate and metastatic spread to other areas of the body. Despite recent advancements in biomedical research, OC detection at an early stage remains a challenge and is complex and inaccurate with conventional diagnostics procedures. It is critical to study innovative approaches that can enable a faster, easier, non-invasive, and more precise diagnosis of OC in order to increase the survival rate of patients. In this paper, we conducted a review on how biosensors might be an excellent tool for detecting OC. This review covers the strategies that use different biosensors to target various types of biomarkers and focuses on biosensors that function at the molecular level viz. DNA biosensors, RNA biosensors, and protein biosensors. In addition, we reviewed non-invasive electrochemical methods, optical methods, and nano biosensors to analyze the OC biomarkers present in body fluids such as saliva and serum. As a result, this review sheds light on the development of ground-breaking biosensors for the early detection and diagnosis of OC. Full article
(This article belongs to the Special Issue Organ-on-a-Chip for Biosensing)
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