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Brain Sciences
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Reviews in Neural Control of Peripheral Function
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Reviews in Neural Control of Peripheral Function

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neural Control of Peripheral Function".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 2261

Special Issue Editors

Dr. Abirami Veluchamy

E-Mail Website
Guest Editor
School of Medicine, University of Dundee, Dundee, UK
Interests: genetic mechanisms of diabetic peripheral neuropathy; chemotherapy-induced neuropathy; neuropathic pain and relevant complications; genetic determinants of retinal features and their link in the prediction of vascular diseases
Dr. Sundararajan Srinivasan

E-Mail Website
Guest Editor
Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK
Interests: multiple sclerosis; neuroscience and diabetes; autoimmune diseases; machine learning; genomics and transcriptomics; peripheral-blood-based transcriptomic signatures for multiple sclerosis

Special Issue Information

Dear Colleagues,

The main purpose of this Special Issue is to gather studies on the neural control of peripheral function, considered to be a set of biological operations and their interactions carried out by the brain and cardiovascular system to understand the vascular biology and genetic background of peripheral nerves. These studies will aim to carry out a more practical level of understanding, showing novel experimental techniques for studying functional interactions associated with peripheral functions for better understanding the precise variation in the activity of the parasympathetic and sympathetic autonomic outflows.

One of the main goals is to explain the importance of peripheral function and how it is associated with cardiovascular control and other tissues to maintain the arterial blood pressure. It is also necessary to discuss and observe functions relevant to arteries and veins and their genetic basis. As a prevalent feature, the studies in this Issue will rely upon the unusual changes in blood pressure, as well as the distribution of blood volume essential to maintain fundamental prefusion of the heart and brain in the face of physiological, genetic, and non-genetic challenges. As neural control provides a powerful mechanism to observe the frequent alterations in cardiac and vascular function are pivotal to maintain blood pressure and appropriately distribute cardiac output in response to physiological and environmental challenge, it is necessary to observe the changes in the brain and heart and how neural control centers modulate them.

Studies related to peripheral mechanisms that control both cardiac and neural receptors are welcome. Proposals must examine the fundamentals of the heart and blood vessels, as well as the sympathetic and parasympathetic nerves, in both healthy people and in brain-damaged patients, or experimental models. In silico studies are also welcome.

Authors are invited to submit relevant original research articles, as well as opinion and review papers.

Dr. Abirami Veluchamy
Dr. Sundararajan Srinivasan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular
  • peripheral circulation
  • sympathetic nerves
  • parasympathetic nerves
  • animal models
  • genetics
  • non-genetics/environmental

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Published Papers (2 papers)

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Research

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13 pages, 3188 KiB  
Article
Understanding the Mechanosensitivity of the Median Nerve in Pre-Surgical Carpal Tunnel Syndrome Patients: A Correlational Study
by Mar Hernández-Secorún, Hugo Abenia-Benedí, María Orosia Lucha-López, María Durán-Serrano, Javier Sami Hamam-Alcober, John Krauss, Christie Booth-Smith and César Hidalgo-García
Brain Sci. 2024, 14(6), 615; https://doi.org/10.3390/brainsci14060615 - 19 Jun 2024
Cited by 1 | Viewed by 1314
Abstract
(1) Background: Neurodynamic tests are recommended for the diagnosis of entrapment neuropathies such as carpal tunnel syndrome (CTS). However, their association with clinical variables in severe patients or patients with associated comorbidities is poorly documented. This study aims to analyze the association between [...] Read more.
(1) Background: Neurodynamic tests are recommended for the diagnosis of entrapment neuropathies such as carpal tunnel syndrome (CTS). However, their association with clinical variables in severe patients or patients with associated comorbidities is poorly documented. This study aims to analyze the association between the mechanosensitivity of the median nerve and symptoms, function and psycho-social variables in moderate and severe carpal tunnel syndrome patients with comorbidities; (2) Methods: Correlational study. In total, 42 pre-surgical patients (24 females; 59.1 ± 12.7 years) included in the Spanish Public Healthcare System with an electrodiagnostic of CTS were selected. Sociodemographic variables and clinical features (symptoms, function, sensitivity and quality of life evaluated with the 36-item Short Form Survey (SF-36) and the Medical Outcomes Study Sleep Scale (MOS-sleep) were recorded. Upper Limb Neurodynamic Test 1 was used to evaluate neural mechanosensitivity; (3) Results: The 81% had a severe CTS and 78.6% had some comorbidity. The average time from the first medical visit to the surgeon’s visit was 365.5 days. Median nerve mechanosensitivity correlated weakly with the SF-36 subscale, General Health, (Spearman’s rho = 0.367) and MOS sleep scale, Awaken Short of Breath or with headache dimension (Spearman’s rho = −0.353) and moderately with SF-36 subscale, Social Functioning (Spearman’s rho = 0.553); (4) Conclusions: No associations were observed for median nerve mechanosensitivity, except for quality of life and sleep. Both social determinants and clinical variables should be considered when examining and treating these patients. Full article
(This article belongs to the Special Issue Reviews in Neural Control of Peripheral Function)
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Review

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14 pages, 3997 KiB  
Review
Peripheral Mechanisms Underlying Bacillus Calmette–Guerin-Induced Lower Urinary Tract Symptoms (LUTS)
by Meera Elmasri, Aaron Clark and Luke Grundy
Brain Sci. 2024, 14(12), 1203; https://doi.org/10.3390/brainsci14121203 - 28 Nov 2024
Viewed by 276
Abstract
Non-muscle invasive bladder cancer (NMIBC) accounts for approximately 70–75% of all bladder cancer cases. The standard treatment for high-risk NMIBC involves transurethral tumour resection followed by intravesical Bacillus Calmette–Guerin (BCG) immunotherapy. While BCG immunotherapy is both safe and effective, it frequently leads to [...] Read more.
Non-muscle invasive bladder cancer (NMIBC) accounts for approximately 70–75% of all bladder cancer cases. The standard treatment for high-risk NMIBC involves transurethral tumour resection followed by intravesical Bacillus Calmette–Guerin (BCG) immunotherapy. While BCG immunotherapy is both safe and effective, it frequently leads to the development of lower urinary tract symptoms (LUTS) such as urinary urgency, frequency, dysuria, and pelvic discomfort. These symptoms can significantly diminish patients’ quality of life and may result in the discontinuation of BCG treatment, adversely affecting oncological outcomes. Despite the considerable clinical impact of BCG-induced LUTS, the underlying mechanisms remain unclear, hindering the implementation or development of effective treatments. This review provides novel insights into the potential mechanisms underlying BCG-induced LUTS, focusing on the integrated roles of afferent and efferent nerves in both normal and pathological bladder sensation and function. Specifically, this review examines how the body’s response to BCG—through the development of inflammation, increased urothelial permeability, and altered urothelial signalling—might contribute to LUTS development. Drawing from known mechanisms in other common urological disorders and data from successful clinical trials involving NMIBC patients, this review summarises evidence supporting the likely changes in both sensory nerve signalling and bladder muscle function in the development of BCG-induced LUTS. However, further research is required to understand the intricate mechanisms underlying the development of BCG-induced LUTS and identify why some patients are more likely to experience BCG intolerance. Addressing these knowledge gaps could have profound implications for patients’ quality of life, treatment adherence, and overall outcomes in NMIBC care. Full article
(This article belongs to the Special Issue Reviews in Neural Control of Peripheral Function)
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