Molecular Motors in Neuronal Homeostasis and Neurodegeneration
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 432
Special Issue Editors
2. UCIBIO—Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal
3. Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Interests: molecular motors; intracellular transport; cell biology; molecular biology; neurodegeneration; drugs of abuse; pharmacology; toxicology; neurotoxicology; forensic sciences
Special Issues, Collections and Topics in MDPI journals
2. UCIBIO-Applied Molecular Biosciences Unit, Toxicologic Pathology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal
Interests: cell biology; molecular biology; pharmacology; neurodegeneration; toxicology; genetics; oncobiology; cytoskeleton
Special Issue Information
Dear Colleagues,
In the intricacies of cellular life, molecular motors stand as the unrecognized protagonists mediating the movements essential for the functioning of living organisms. These nanoscale machines, such as kinesins, dyneins, and myosins, powered by the energy currency of the cell, navigate through the complex cellular environment, transporting cargo, facilitating cellular division, and contributing to a variety of physiological processes.
Through a comprehensive review of current literature and original research contributions, we aim to elucidate the mechanisms underlying motor protein-mediated transport processes and their implications in maintaining neuronal health or precipitating neurodegenerative conditions. Topics of interest include the role of motors in neuronal development (neurogenesis), dynamics of microtubules, cellular trafficking, and synaptic plasticity, and the involvement of molecular motors in glial cell functions and neuroimmunomodulation. In addition, we are also interested in studies that potentially implicate molecular motors as putative biomarkers for early diagnosis and their potential to enable the precise targeting of therapeutics toward the affected neuronal populations or even molecules or gene therapies designed to modulate motor activity or enhance axonal transport to ameliorate neurodegenerative processes.
Thus, by bridging the gap between basic science and clinical applications, this Special Issue aims to foster our understanding of molecular motors in neuronal homeostasis and neurodegeneration.
Dr. Daniel José Barbosa
Dr. Ana Filipa Sobral
Guest Editors
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Keywords
- molecular motors
- kinesins
- dynein
- myosins
- neuronal homeostasis
- neuronal development
- cellular trafficking
- synaptic plasticity
- biomarkers of early diagnosis
- neurodegeneration
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