Molecular and Cellular Advances on Drug Discovery, Pharmacology and Toxicology, 2nd Edition

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1065

Special Issue Editors


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Guest Editor
1. Associate Laboratory i4HB, Institute for Health and Bioeconomy, University Institute of Health Sciences—CESPU, 4585-116 Gandra, Portugal
2. UCIBIO—Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal
3. Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Interests: molecular motors; intracellular transport; cell biology; molecular biology; neurodegeneration; drugs of abuse; pharmacology; toxicology; neurotoxicology; forensic sciences
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Associate Laboratory i4HB, Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal
2. UCIBIO—Applied Molecular Biosciences Unit, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: toxicology; pharmacology; ADME/toxicokinetics; membrane transporters; P-glycoprotein; neurodegeneration; drugs of abuse; drug discovery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In biomedical sciences, the identification/discovery of novel therapeutics, efficient pharmacological interventions, and comprehensive toxicological assessments has become dominant. In recent years, there has been an unprecedented convergence of multidisciplinary research, integrating molecular and cellular biology with drug discovery, pharmacology, and toxicology. This synergy has not only accelerated the identification of potential new therapeutic targets but has also enhanced our understanding of the intricate mechanisms governing drug response and toxicity.

In an era where precision medicine, targeted therapies, and emergent drug abuse dominate scientific research, the convergence of molecular and cellular insights with drug discovery and toxicology has become indispensable, fostering a deeper understanding of the molecular foundations of diseases, the pharmacological intricacies of therapeutic agents, and the safety considerations vital for clinical translation.

In this Special Issue, we are interested in reviews and original articles describing cellular and molecular advances on drug discovery, pharmacology, and toxicology, in in vitro and in vivo models; or reporting evidence and expectations attained from the in silico modeling of existing and novel compounds with potential biological activity.

Dr. Daniel José Barbosa
Dr. Renata Silva
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug discovery
  • pharmacological activity
  • toxicological profile
  • in vitro models
  • in vivo models
  • new biological compounds
  • drugs of abuse

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Published Papers (1 paper)

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Research

11 pages, 1705 KiB  
Article
Development of a Short-Term Embolic Agent Based on Cilastatin for Articular Microvessels
by Hyun Jin Kim, Areum Jeon, Eun Kyung Kang, Wen An, So Jung Lim, Kyu Chul Shin, Dong Hun Shin, Inyoung Hwang and Ju Seop Kang
Medicina 2024, 60(9), 1538; https://doi.org/10.3390/medicina60091538 - 20 Sep 2024
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Abstract
Background and Objectives: This study aimed to develop an embolic agent with short-term embolic effects using cilastatin as the basic material. Materials and Methods: The particle size distribution of 25 mg cilastatin-based short-term embolic agents was evaluated microscopically under three different [...] Read more.
Background and Objectives: This study aimed to develop an embolic agent with short-term embolic effects using cilastatin as the basic material. Materials and Methods: The particle size distribution of 25 mg cilastatin-based short-term embolic agents was evaluated microscopically under three different mixing conditions. A total of thirty-six healthy male Sprague Dawley rats were divided into four groups. Each group of six rats was injected once into the tail artery with 0.4 mL each of (A) Cilastatin + D-Mannitol Mixture, (B) Iohexol, (C) Prepenem, and (D) embolization promoter (EGgel). Results: A visual inspection of the tail appearance of rats in each group was performed at 0, 3, 7, 15, and 21 days. At weeks 1 and 3, three rats per group were euthanized, and histopathological analyses were performed on the specimens obtained from each group. No significant differences were observed on day 7, but mild inflammation was observed in Group (D) on day 15. Histopathological inflammation scoring of tail central artery embolization was performed using a six-point scale (from 0 = absent to 5 = marked inflammation). Three groups were formed consisting of six male New Zealand white rabbits each: control, positive control, and test groups. The control group received an Iohexol injection (rabbits: 0.8 mL). The positive control and experimental groups were injected with prepenem and cilastatin/D-mannitol compound, respectively (0.8 mL), and vascular angiography was performed. The order of occlusion progression after embolization was as follows: test group, positive control group, and control group. Conclusions: We developed a cilastatin/D-mannitol compound that exhibits characteristics of short-term embolization by utilizing the pharmacokinetic properties of cilastatin and the crystalline material D-mannitol. We evaluated its particle size distribution microscopically, conducted histopathological evaluation including inflammation via animal experiments, and assessed the embolization effect. Full article
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