Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.8
2.7
Journals
Brain Sciences
Special Issues
Advances in Interdisciplinary Tinnitus and Hyperacusis Research
share announcement

Advances in Interdisciplinary Tinnitus and Hyperacusis Research

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuro-otology and Neuro-ophthalmology".

Deadline for manuscript submissions: closed (27 September 2022) | Viewed by 15720

Special Issue Editors

Dr. Sonja J. Pyott

E-Mail Website
Guest Editor
Department of Otorhinolaryngology, University Medical Center Groningen, Han-zeplein 1 (BB20), 9700 RB Groningen, The Netherlands
Interests: inner ear biology and physiology; age-related auditory and vestibular decline; patho-physiology of tinnitus; comparative auditory function
Prof. Dr. Agnieszka Szczepek

E-Mail Website
Co-Guest Editor
Department of Otorhinolaryngology, Head and Neck Surgery, Charité Universitätsmedizin, Berlin, Germany
Interests: hearing research; inner ear immunology; ototoxicity
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Pim van Dijk

E-Mail Website
Co-Guest Editor
Department of Otorhinolaryngology, University Medical Center Groningen, Hanzeplein 1 (BB20), 9700 RB Groningen, The Netherlands
Interests: tinnitus; brain imaging; otoacoustic emissions
Dr. Elouise Koops

E-Mail Website
Co-Guest Editor
Eaton-Peabody Lab, Massachusetts Eye and Ear/Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA
Interests: EEG; rTMS; MRI; functional MRI; voxel-based morphometry; surface-based morphometry; higher-order diffusion-weighted imaging; resting-state fMRI analyses
Special Issues, Collections and Topics in MDPI journals
Dr. Arnaud Jean Noreña

E-Mail Website
Co-Guest Editor
Laboratoire Neurosciences Intégratives et Adaptatives, UMR CNRS 7260, Fédération 3C, Aix-Marseille Université, Marseille, France
Interests: audiology; auditory perception; auditory neuroscience; tinnitus; hyperacusis; misophonia
Prof. Dr. Holger Schulze

E-Mail Website
Co-Guest Editor
ENT-Clinic, University Hospital Erlangen, 91054 Erlangen, Germany
Interests: neuroscience; neurophysiology; learning; neurobiology; physiology; neurobiology and brain physiology; audiology; hearing disorders; ear; brain
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tinnitus, or “ringing” in the ears, is a widespread and potentially devastating condition. People with tinnitus continuously hear a penetrating phantom sound in the absence of actual sound. Tinnitus can be enormously debilitating and leads to difficulty concentrating, lack of sleep, anxiety, and depression. Even mild forms of tinnitus reduce productivity due to hearing and concentrating difficulties at work, or relaxing difficulties during leisure time. Tinnitus is often linked to hearing loss and hyperacusis, an exaggerated response (from annoyance to fear and pain) to ordinary sounds in the environment that are tolerated by others without hyperacusis. To cure tinnitus and better understand the links between tinnitus, hearing loss, and hyperacusis, TIN-ACT, a European consortium (https://www.tinact.eu/), brings together researchers, clinicians, and industrial partners to bridge the gap between basic research, applied clinical research, and product development.

The concept for this Special Issue originated from the Coordinator and Investigators of the European Union-funded project—the Research School for Tinnitus Assessment, Causes and Treatments (TIN-ACT). TIN-ACT supports the training of 15 early career researchers (https://www.tinact.eu/ and https://cordis.europa.eu/project/id/764604). In addition to the Special Issue Editors, the following supervisors/beneficiaries also provide expertise as Special Issue Affiliate Guest Editors:

Prof. Dr. Birgit Mazurek (Charite – Universitaetsmedizin Berlin)
Dr. Konstantin Tziridis (Universitatsklinikum Erlangen)
Dr. Laurent Pezard (Centre National de la Recherche Scientifique)
Prof. Dr. Dorothee Auer (University of Nottingham)
Prof. Dr. Michael Akeroyd (University of Nottingham)
Prof. Dr. Katrin Krumbholz (University of Nottingham)
Dr. James Harte (Oticon A/S)
Dr. Sueli Caporali (Widex A/S)
Dr. Filiep Vanpoucke (Cochlear Research and Development Limited)

This Special Issue will bring together research from the TIN-ACT consortium and its collaborators and bring attention to the interdisciplinary research needed to investigate tinnitus and develop treatments. Potential topics include but are not limited to:

  • Clinical assessment of tinnitus and hyperacusis;
  • The role of central gain in tinnitus and hyperacusis;
  • Neural markers of tinnitus;
  • Brain and brainstem imaging to investigate tinnitus and hyperacusis;
  • The role of stress in tinnitus;
  • Genetic mechanisms underlying tinnitus;
  • Hearing aids and cochlear implants to improve tinnitus.

Dr. Sonja J. Pyott
Prof. Dr. Agnieszka Szczepek
Prof. Dr. Pim van Dijk
Dr. Elouise Koops
Dr. Arnaud Jean Noreña
Prof. Dr. Holger Schulze
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tinnitus
  • hyperacusis
  • hearing loss
  • markers/biomarkers
  • tinnitus therapy
  • sound therapy
  • stress and auditory system

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

18 pages, 1517 KiB  
Article
A Combined Image- and Coordinate-Based Meta-Analysis of Whole-Brain Voxel-Based Morphometry Studies Investigating Subjective Tinnitus
by Punitkumar Makani, Marc Thioux, Sonja J. Pyott and Pim van Dijk
Brain Sci. 2022, 12(9), 1192; https://doi.org/10.3390/brainsci12091192 - 3 Sep 2022
Cited by 7 | Viewed by 2553
Abstract
Previous voxel-based morphometry (VBM) studies investigating tinnitus have reported structural differences in a variety of spatially distinct gray matter regions. However, the results have been highly inconsistent and sometimes contradictory. In the current study, we conducted a combined image- and coordinate-based meta-analysis of [...] Read more.
Previous voxel-based morphometry (VBM) studies investigating tinnitus have reported structural differences in a variety of spatially distinct gray matter regions. However, the results have been highly inconsistent and sometimes contradictory. In the current study, we conducted a combined image- and coordinate-based meta-analysis of VBM studies investigating tinnitus to identify robust gray matter differences associated with tinnitus, as well as examine the possible effects of hearing loss on the outcome of the meta-analysis. The PubMed and Web of Science databases were searched for studies published up to August 2021. Additional manual searches were conducted for studies published up to December 2021. A whole-brain meta-analysis was performed using Seed-Based d Mapping with Permutation of Subject Images (SDM-PSI). Fifteen studies comprising 423 individuals with tinnitus and either normal hearing or hearing loss (mean age 50.94 years; 173 females) and 508 individuals without tinnitus and either normal hearing or hearing loss (mean age 51.59 years; 234 females) met the inclusion criteria. We found a small but significant reduction in gray matter in the left inferior temporal gyrus for groups of normal hearing individuals with tinnitus compared to groups of hearing-matched individuals without tinnitus. In sharp contrast, in groups with hearing loss, tinnitus was associated with increased gray matter levels in the bilateral lingual gyrus and the bilateral precuneus. Those results were dependent upon matching the hearing levels between the groups with or without tinnitus. The current investigation suggests that hearing loss is the driving force of changes in cortical gray matter across individuals with and without tinnitus. Future studies should carefully account for confounders, including hearing loss, hyperacusis, anxiety, and depression, to identify gray matter changes specifically related to tinnitus. Ultimately, the aggregation of standardized individual datasets with both anatomical and useful phenotypical information will permit a better understanding of tinnitus-related gray matter differences, the effects of potential comorbidities, and their interactions with tinnitus. Full article
(This article belongs to the Special Issue Advances in Interdisciplinary Tinnitus and Hyperacusis Research)
►▼ Show Figures

Figure 1

13 pages, 1895 KiB  
Article
Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study
by Wei Li, Xiaobo Ma, Qian Wang, Xueying He, Xiaoxia Qu, Lirong Zhang, Lanyue Chen and Zhaohui Liu
Brain Sci. 2022, 12(8), 1049; https://doi.org/10.3390/brainsci12081049 - 8 Aug 2022
Cited by 2 | Viewed by 2664
Abstract
Previous studies have found a link between tinnitus and cognitive impairment, even leading to dementia. However, the mechanisms underlying this association are not clear. The purpose of this study was to explore intrinsic network changes in tinnitus and hearing loss patients with cognitive [...] Read more.
Previous studies have found a link between tinnitus and cognitive impairment, even leading to dementia. However, the mechanisms underlying this association are not clear. The purpose of this study was to explore intrinsic network changes in tinnitus and hearing loss patients with cognitive disorders. We included 17 individuals with bilateral idiopathic tinnitus, hearing loss, and cognitive impairment (PA) and 21 healthy controls. We identified resting-state networks (RSNs) and measured intra-network functional connectivity (FC) values via independent component analysis (ICA). We also evaluated correlations between RSNs and clinical characteristics. Compared with the healthy controls, the PA group showed decreased connectivity within the ventral attention network, dorsal attention network (DAN), visual network, left frontoparietal network, right frontoparietal network, sensorimotor network, and increased connectivity within the executive control network. MoCA (Montreal Cognitive Assessment) scores were negatively correlated with the FC values for left calcarine within the DAN. We identified abnormal intrinsic connectivity in several brain networks, mainly involving cognitive control, vision, sensorimotor function, and the cerebellum, in tinnitus patients with cognitive impairment. It may be possible to use the FC strength of the left calcarine within the DAN as an imaging marker to predict cognitive impairment in tinnitus patients. Full article
(This article belongs to the Special Issue Advances in Interdisciplinary Tinnitus and Hyperacusis Research)
►▼ Show Figures

Figure 1

19 pages, 2969 KiB  
Article
Broadband Amplification as Tinnitus Treatment
by Mie Laerkegaard Joergensen, Petteri Hyvärinen, Sueli Caporali and Torsten Dau
Brain Sci. 2022, 12(6), 719; https://doi.org/10.3390/brainsci12060719 - 31 May 2022
Cited by 2 | Viewed by 3144
Abstract
This study investigated the effect of broadband amplification (125 Hz to 10 kHz) as tinnitus treatment for participants with high-frequency hearing loss and compared these effects with an active placebo condition using band-limited amplification (125 Hz to 3–4 kHz). A double-blinded crossover study. [...] Read more.
This study investigated the effect of broadband amplification (125 Hz to 10 kHz) as tinnitus treatment for participants with high-frequency hearing loss and compared these effects with an active placebo condition using band-limited amplification (125 Hz to 3–4 kHz). A double-blinded crossover study. Twenty-three participants with high-frequency (≥3 kHz) hearing loss and chronic tinnitus were included in the study, and 17 completed the full treatment protocol. Two different hearing aid treatments were provided for 3 months each: Broadband amplification provided gain in the frequency range from 125 Hz to 10 kHz and band-limited amplification only provided gain in the low-frequency range (≤3–4 kHz). The effect of the two treatments on tinnitus distress was evaluated with the Tinnitus Handicap Inventory (THI) and the Tinnitus Functional Index (TFI) questionnaires. The effect of the treatment on tinnitus loudness was evaluated with a visual analog scale (VAS) for loudness and a psychoacoustic loudness measure. Furthermore, the tinnitus annoyance was evaluated with a VAS for annoyance. The tinnitus pitch was evaluated based on the tinnitus likeness spectrum. A statistically significant difference was found between the two treatment groups (broadband vs. band-limited amplification) for the treatment-related change in THI and TFI with respect to the baseline. Furthermore, a statistically significant difference was found between the two treatment conditions for the annoyance measure. Regarding the loudness measure, no statistically significant differences were found between the treatments, although there was a trend towards a lower VAS-based loudness measure resulting from the broadband amplification. No changes were observed in the tinnitus pitch between the different conditions. Overall, the results from the present study suggest that tinnitus patients with high-frequency hearing loss can experience a decrease in tinnitus-related distress and annoyance from high-frequency amplification. Full article
(This article belongs to the Special Issue Advances in Interdisciplinary Tinnitus and Hyperacusis Research)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

11 pages, 247 KiB  
Review
Tinnitus and Traumatic Memory
by Marc Fagelson
Brain Sci. 2022, 12(11), 1585; https://doi.org/10.3390/brainsci12111585 - 20 Nov 2022
Cited by 3 | Viewed by 3036
Abstract
Events linked to post-traumatic stress disorder (PTSD) influence psychological and physical health through the generation, exacerbation, and maintenance of symptoms such as anxiety, hyperarousal, and avoidance. Depending upon circumstance, traumatic events may also contribute to the onset of tinnitus, post-traumatic headache, and memory [...] Read more.
Events linked to post-traumatic stress disorder (PTSD) influence psychological and physical health through the generation, exacerbation, and maintenance of symptoms such as anxiety, hyperarousal, and avoidance. Depending upon circumstance, traumatic events may also contribute to the onset of tinnitus, post-traumatic headache, and memory problems. PTSD should be considered a psychological injury, andwhile tinnitus is a symptom, its onset and sound quality may be connected in memory to the injury, thereby evincingthe capacity to exacerbate the trauma’s effects. The myriad attributes, psychological and mechanistic, shared by tinnitus and PTSD offer tinnitus investigators the opportunity to draw from the rich and long-practiced strategies implemented for trauma counseling. Mechanisms and interventions understood through the lens of traumatic exposures may inform the clinical management of tinnitus disorder, and future studies may assess the effect of PTSD intervention on co-occurring conditions. This brief summary considered literature from both the hearing and trauma disciplines, with the goal of reviewing mechanisms shared between tinnitus and PTSD, as well as clinical reports supporting mutual reinforcement of both their symptoms and the effects of therapeutic approaches. Full article
(This article belongs to the Special Issue Advances in Interdisciplinary Tinnitus and Hyperacusis Research)

Other

Jump to: Research, Review

23 pages, 3476 KiB  
Systematic Review
Effects of Physical Interventions on Subjective Tinnitus, a Systematic Review and Meta-Analysis
by Eric J. Bousema, Elouise A. Koops, Pim van Dijk and Pieter U. Dijkstra
Brain Sci. 2023, 13(2), 226; https://doi.org/10.3390/brainsci13020226 - 29 Jan 2023
Cited by 1 | Viewed by 2551
Abstract
Increasingly, patients suffering from subjective tinnitus seek help from physical therapists. Numerous randomised controlled trials (RCTs) have investigated the effect of physical interventions commonly used in physical therapy practice on subjective tinnitus. This systematic review and meta-analysis aimed to analyse the effects of [...] Read more.
Increasingly, patients suffering from subjective tinnitus seek help from physical therapists. Numerous randomised controlled trials (RCTs) have investigated the effect of physical interventions commonly used in physical therapy practice on subjective tinnitus. This systematic review and meta-analysis aimed to analyse the effects of physical interventions on tinnitus loudness, tinnitus annoyance, and scores on the Tinnitus Handicap Index (THI). Four databases were searched from inception up to March 2022. A total of 39 RCTs were included in the systematic review, and 23 studies were appropriate for meta-analyses. Risk of bias assessments were also performed. Interventions analysed in at least five studies were summarised, including transcutaneous electrical nerve stimulation (TENS), laser therapy, and acupuncture. Random-effects meta-analysis models were used, and effect sizes were expressed as Hedge’s standardised mean differences (SMD) with 95%CI’s. The quality of three-quarters of the studies was limited due to insufficient allocation concealment, lack of adequate blinding, and small sample sizes. Large, pooled effects sizes were found for acupuncture (SMD: 1.34; 95%CI: 0.79, 1.88) and TENS (SMD: 1.17; 95%CI: 0.48, 1.87) on THI as well as for acupuncture on tinnitus loudness (VAS Loudness (SMD: 0.84; 95%CI: 0.33, 1.36) and tinnitus annoyance (SMD: 1.18; 95%CI: 0.00, 2.35). There is some evidence that physical interventions (TENS and acupuncture, but not laser therapy) may be effective for tinnitus. However, the lack of high-quality studies and the risk of bias in many studies prohibits stronger conclusions. Full article
(This article belongs to the Special Issue Advances in Interdisciplinary Tinnitus and Hyperacusis Research)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop