Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.8
2.7
Journals
Brain Sciences
Special Issues
Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and...
share announcement

Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Behavioral Neuroscience".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 30637

Special Issue Editors

Dr. Mohammed Ali Salehinejad

E-Mail Website
Guest Editor
Department of Psychology and Neurosciences, Leibniz Research Institute for Working Environment and Human Factors, 44139 Dortmund, Germany
Interests: cognitive neuroscience; non-invasive brain stimulation; neuroimaging; neuroplasticity; cortical excitability
Prof. Dr. Carmelo M Vicario

E-Mail Website
Guest Editor
Cognitive Neuroscience Lab, Department of Cognitive Science, University of Messina, 98122 Messina, Italy
Interests: neuroscience; cognitive psychology; affective psychology; social neuroscience; clinical neuroscience
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Transcranial electrical stimulation (tES) has been exponentially applied in recent years, especially in human research. In addition to the physiological effects of tES techniques on the human brain, which is well documented, there are also potential opportunities for improving behavior and cognition. The current findings in this respect have been promising in some fields; however, they have been inconsistent as well. Moreover, the application of some novel techniques (e.g., tACS, tRNS) for the improvement of behavior and cognition is yet to be investigated. Accordingly, there is still a need for more high-quality research in this field.

This special issue covers recent findings on the application of transcranial electrical stimulation (tES), including tDCS, tACS, tRNS, for improving cognition in healthy individuals, as well as neurorehabilitation purposes in clinical populations. Topics related to the variability of therapeutic response to tES are of special interest in this issue.

Papers that report the use of cutting-edge methods, including multimodal imaging, concurrent brain stimulation–neuroimaging, and individualized/personalized stimulation protocols are also of interest.

Full-length original research articles and reports, review and metanalytic articles (narrative reviews, systematic reviews, meta-analyses), methodology articles, opinion/perspective articles, and case reports will be considered for publication.

Dr. Mohammed Ali Salehinejad
Prof. Dr. Carmelo M Vicario
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcranial electrical stimulation (tES)
  • tDCS
  • cognition
  • motor behavior
  • gait behavior
  • neuroplasticity
  • motor excitability
  • motor cortex
  • prefrontal cortex
  • memory
  • neurorehabilitation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (8 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

22 pages, 1597 KiB  
Article
Optimizing the Effect of tDCS on Motor Sequence Learning in the Elderly
by Ensiyeh Ghasemian-Shirvan, Ruxandra Ungureanu, Lorena Melo, Kim van Dun, Min-Fang Kuo, Michael A. Nitsche and Raf L. J. Meesen
Brain Sci. 2023, 13(1), 137; https://doi.org/10.3390/brainsci13010137 - 12 Jan 2023
Cited by 8 | Viewed by 2691
Abstract
One of the most visible effects of aging, even in healthy, normal aging, is a decline in motor performance. The range of strategies applicable to counteract this deterioration has increased. Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that can promote [...] Read more.
One of the most visible effects of aging, even in healthy, normal aging, is a decline in motor performance. The range of strategies applicable to counteract this deterioration has increased. Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that can promote neuroplasticity, has recently gained attention. However, knowledge about optimized tDCS parameters in the elderly is limited. Therefore, in this study, we investigated the effect of different anodal tDCS intensities on motor sequence learning in the elderly. Over the course of four sessions, 25 healthy older adults (over 65 years old) completed the Serial Reaction Time Task (SRTT) while receiving 1, 2, or 3 mA of anodal or sham stimulation over the primary motor cortex (M1). Additionally, 24 h after stimulation, motor memory consolidation was assessed. The results confirmed that motor sequence learning in all tDCS conditions was maintained the following day. While increased anodal stimulation intensity over M1 showed longer lasting excitability enhancement in the elderly in a prior study, the combination of higher intensity stimulation with an implicit motor learning task showed no significant effect. Future research should focus on the reason behind this lack of effect and probe alternative stimulation protocols. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

12 pages, 2701 KiB  
Article
Effect of Single Session of Anodal M1 Transcranial Direct Current Stimulation—TDCS—On Cortical Hemodynamic Activity: A Pilot Study in Fibromyalgia
by Marianna La Rocca, Livio Clemente, Eleonora Gentile, Katia Ricci, Marianna Delussi and Marina de Tommaso
Brain Sci. 2022, 12(11), 1569; https://doi.org/10.3390/brainsci12111569 - 18 Nov 2022
Cited by 4 | Viewed by 1763
Abstract
Transcranial direct current stimulation (TDCS) on the primary motor cortex (M1) has been reported to be effective in fibromyalgia (FM). Our previous works have shown hypometabolism of motor networks in FM using Functional Near Infrared Spectroscopy (fNIRS), which could contribute to pain symptoms. [...] Read more.
Transcranial direct current stimulation (TDCS) on the primary motor cortex (M1) has been reported to be effective in fibromyalgia (FM). Our previous works have shown hypometabolism of motor networks in FM using Functional Near Infrared Spectroscopy (fNIRS), which could contribute to pain symptoms. To investigate if a single Transcranial Direct Current Stimulation (TDCS) session can restore the reduced metabolism expected in FM patients, we compared metabolic activity in FM patients and controls during a finger-tapping task in basal condition, sham condition, and under anodal TDCS on M1. During the finger tapping task, a continuous wave 20 channel fNIRS system was placed across the bilateral central-frontal areas in 22 healthy controls and 54 FM patients. Subjects were randomly assigned to real TDCS or sham stimulation. The finger-tapping slowness did not change after real and sham stimulation. After real TDCS stimulation, FM patients showed an increased activation of cortical motor regions (t-statistic = −2.5246, p-value = 0.0125 for the stimulated hemisphere and t-statistic = −4.6638, p-value = 0.0001 for the non-stimulated hemisphere). The basal differences between FM and controls reverted after real TDCS, while this effect was not observed for sham stimulation. A single TDCS session of the cortical motor network seemed able to restore basic cortical hypometabolism in FM patients. Further studies could clarify the long-term effect of M1 stimulation on cortical metabolism, and its relevance in pain processing and clinical features. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

14 pages, 1115 KiB  
Article
Repetitive Anodal TDCS to the Frontal Cortex Increases the P300 during Working Memory Processing
by Angela Voegtle, Christoph Reichert, Hermann Hinrichs and Catherine M. Sweeney-Reed
Brain Sci. 2022, 12(11), 1545; https://doi.org/10.3390/brainsci12111545 - 14 Nov 2022
Cited by 6 | Viewed by 2240
Abstract
Transcranial direct current stimulation (TDCS) is a technique with which neuronal activity, and therefore potentially behavior, is modulated by applying weak electrical currents to the scalp. Application of TDCS to enhance working memory (WM) has shown promising but also contradictory results, and little [...] Read more.
Transcranial direct current stimulation (TDCS) is a technique with which neuronal activity, and therefore potentially behavior, is modulated by applying weak electrical currents to the scalp. Application of TDCS to enhance working memory (WM) has shown promising but also contradictory results, and little emphasis has been placed on repeated stimulation protocols, in which effects are expected to be increased. We aimed to characterize potential behavioral and electrophysiological changes induced by TDCS during WM training and evaluate whether repetitive anodal TDCS has a greater modulatory impact on the processes underpinning WM than single-session stimulation. We examined the effects of single-session and repetitive anodal TDCS to the dorsolateral prefrontal cortex (DLPFC), targeting the frontal-parietal network, during a WM task in 20 healthy participants. TDCS had no significant impact on behavioral measures, including reaction time and accuracy. Analyzing the electrophysiological response, the P300 amplitude significantly increased following repetitive anodal TDCS, however, positively correlating with task performance. P300 changes were identified over the parietal cortex, which is known to engage with the frontal cortex during WM processing. These findings support the hypothesis that repetitive anodal TDCS modulates electrophysiological processes underlying WM. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

11 pages, 771 KiB  
Article
The Impact of Bilateral Anodal tDCS over Left and Right DLPFC on Executive Functions in Children with ADHD
by Mohammad Ali Salehinejad, Younes Vosough and Vahid Nejati
Brain Sci. 2022, 12(8), 1098; https://doi.org/10.3390/brainsci12081098 - 18 Aug 2022
Cited by 8 | Viewed by 3171
Abstract
Transcranial direct current stimulation (tDCS) is increasingly used for therapeutic purposes in attention-deficit hyperactivity disorder (ADHD). The dorsolateral prefrontal cortex (DLPFC) is the most targeted region of tDCS studies in ADHD. There is limited knowledge and mixed results about the relevance of left [...] Read more.
Transcranial direct current stimulation (tDCS) is increasingly used for therapeutic purposes in attention-deficit hyperactivity disorder (ADHD). The dorsolateral prefrontal cortex (DLPFC) is the most targeted region of tDCS studies in ADHD. There is limited knowledge and mixed results about the relevance of left or right DLPFCs in ADHD’s cognitive deficits. No study so far has investigated the impact of the increased excitability of both left and right DLPFC with anodal tDCS on cognitive deficits in ADHD. Here, we explored the impact of online bilateral anodal left and right DLPFC tDCS on executive dysfunction in children with ADHD. Twenty-two children with ADHD (mean age ± SD =8.86 ± 1.80) received bilateral anodal online tDCS over the left and right DLPFC (1.5 mA, 15 min) in two separate sessions in active and sham states. They underwent a battery of four neuropsychological tasks of executive functions during stimulation that measured working memory, cognitive flexibility, response inhibition, and executive control. Bilateral anodal left and right DLPFC tDCS did not improve performance on working memory, cognitive flexibility, and response inhibition. Executive control was, however, partially improved for those who received active tDCS first. The upregulation of bilateral DLPFC tDCS with anodal polarity does not improve executive dysfunction in children with ADHD. The unilateral modulation of DLPFC with anodal tDCS may be more beneficial to cognitive deficits in ADHD in light of previous works targeting only left and/or right DLPFC. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

10 pages, 1573 KiB  
Article
Timing-Dependent Effects of Transcranial Direct Current Stimulation on Hand Motor Function in Healthy Individuals: A Randomized Controlled Study
by Nam-Gyu Jo, Gi-Wook Kim, Yu Hui Won, Sung-Hee Park, Jeong-Hwan Seo and Myoung-Hwan Ko
Brain Sci. 2021, 11(10), 1325; https://doi.org/10.3390/brainsci11101325 - 6 Oct 2021
Cited by 4 | Viewed by 2351
Abstract
The timing of transcranial direct current stimulation (tDCS) is essential for enhancing motor skill learning. Previously, tDCS, before or concurrently, with motor training was evaluated in healthy volunteers or elderly patients, but the optimal timing of stimulation has not been determined. In this [...] Read more.
The timing of transcranial direct current stimulation (tDCS) is essential for enhancing motor skill learning. Previously, tDCS, before or concurrently, with motor training was evaluated in healthy volunteers or elderly patients, but the optimal timing of stimulation has not been determined. In this study, we aimed to optimize the existing tDCS protocols by exploring the timing-dependent stimulation effects on finger movements in healthy individuals. We conducted a single-center, prospective, randomized controlled trial. The study participants (n = 39) were randomly assigned into three groups: tDCS concurrently with finger tapping training (CON), tDCS prior to finger tapping training (PRI), and SHAM-tDCS simultaneously with finger tapping training (SHAM). In all groups, the subjects participated in five 40-min training sessions for one week. Motor performance was measured before and after treatment using the finger-tapping task (FTT), the grooved pegboard test (GPT), and hand strength tests. tDCS treatment prior to finger tapping training significantly improved motor skill learning, as indicated by the GPT and hand strength measurements. In all groups, the treatment improved the FTT performance. Our results indicate that applying tDCS before training could be optimal for enhancing motor skill learning. Further research is required to confirm these findings. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

Other

Jump to: Research

12 pages, 1847 KiB  
Study Protocol
MRI-Based Personalized Transcranial Direct Current Stimulation to Enhance the Upper Limb Function in Patients with Stroke: Study Protocol for a Double-Blind Randomized Controlled Trial
by Yeun Jie Yoo, Hye Jung Park, Tae Yeong Kim, Mi-Jeong Yoon, Hyun-Mi Oh, Yoon Jung Lee, Bo Young Hong, Donghyeon Kim, Tae-Woo Kim and Seong Hoon Lim
Brain Sci. 2022, 12(12), 1673; https://doi.org/10.3390/brainsci12121673 - 5 Dec 2022
Cited by 7 | Viewed by 2852
Abstract
Transcranial direct current stimulation (tDCS) has been shown to have the potential to improve the motor recovery of the affected upper limbs in patients with stroke, and recently, several optimized tDCS methods have been proposed to magnify its effectiveness. This study aims to [...] Read more.
Transcranial direct current stimulation (tDCS) has been shown to have the potential to improve the motor recovery of the affected upper limbs in patients with stroke, and recently, several optimized tDCS methods have been proposed to magnify its effectiveness. This study aims to determine the effectiveness of personalized tDCS using brain MRI-based electrical field simulation and optimization, to enhance motor recovery of the upper limbs in the patients. This trial is a double-blind, randomized controlled trial in the subacute to chronic rehabilitation phase. Forty-two adult stroke patients with unilateral upper limb involvement will be randomly allocated to three groups: (1) personalized tDCS with MRI-based electrical field simulation and optimized stimulation, (2) conventional tDCS with bihemispheric stimulation of the primary motor cortex, and (3) sham tDCS. All three groups will undergo 10 intervention sessions with 30 min of 2-mA intensity stimulation, during a regular upper limb rehabilitation program over two weeks. The primary outcome measure for the motor recovery of the upper limb impairment is the Fugl–Meyer assessment for the upper extremity score at the end of the intervention, and the secondary measures include changes in the motor evoked potentials, the frequency power and coherence of the electroencephalography, performance in activities of daily living, and adverse events with a 1-month follow-up assessment. The primary outcome will be analyzed on the intention-to-treat principle. There is a paucity of studies regarding the effectiveness of personalized and optimized tDCS that considers individual brain lesions and electrical field characteristics in the real world. No feasibility or pivotal studies have been performed in stroke patients using brain MRI, to determine a lesion-specific tDCS simulation and optimization that considers obstacles in the segmentation and analysis of the affected brain tissue, such as ischemic and hemorrhagic lesions. This trial will contribute to addressing the effectiveness and safety of personalized tDCS, using brain MRI-based electrical field simulation and optimization, to enhance the motor recovery of the upper limbs in patients with stroke. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

18 pages, 1325 KiB  
Study Protocol
Personalized Frequency Modulated Transcranial Electrical Stimulation for Associative Memory Enhancement
by Jovana Bjekić, Marko Živanović, Dunja Paunović, Katarina Vulić, Uroš Konstantinović and Saša R. Filipović
Brain Sci. 2022, 12(4), 472; https://doi.org/10.3390/brainsci12040472 - 2 Apr 2022
Cited by 4 | Viewed by 4288
Abstract
Associative memory (AM) is the ability to remember the relationship between previously unrelated items. AM is significantly affected by normal aging and neurodegenerative conditions, thus there is a growing interest in applying non-invasive brain stimulation (NIBS) techniques for AM enhancement. A growing body [...] Read more.
Associative memory (AM) is the ability to remember the relationship between previously unrelated items. AM is significantly affected by normal aging and neurodegenerative conditions, thus there is a growing interest in applying non-invasive brain stimulation (NIBS) techniques for AM enhancement. A growing body of studies identifies posterior parietal cortex (PPC) as the most promising cortical target for both transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES) to modulate a cortico-hippocampal network that underlines AM. In that sense, theta frequency oscillatory tES protocols, targeted towards the hallmark oscillatory activity within the cortico-hippocampal network, are increasingly coming to prominence. To increase precision and effectiveness, the need for EEG guided individualization of the tES protocols is proposed. Here, we present the study protocol in which two types of personalized oscillatory tES–transcranial alternating current stimulation (tACS) and oscillatory transcranial direct current stimulation (otDCS), both frequency-modulated to the individual theta-band frequency (ITF), are compared to the non-oscillatory transcranial direct current stimulation (tDCS) and to the sham stimulation. The study has cross-over design with four tES conditions (tACS, otDCS, tDCS, sham), and the comprehensive set of neurophysiological (resting state EEG and AM-evoked EEG) and behavioral outcomes, including AM tasks (short-term associative memory, face–word, face–object, object-location), as well as measures of other cognitive functions (cognitive control, verbal fluency, and working memory). Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

12 pages, 1221 KiB  
Study Protocol
Non-Invasive Transcutaneous Vagus Nerve Stimulation for the Treatment of Fibromyalgia Symptoms: A Study Protocol
by Andrés Molero-Chamizo, Michael A. Nitsche, Armin Bolz, Rafael Tomás Andújar Barroso, José R. Alameda Bailén, Jesús Carlos García Palomeque and Guadalupe Nathzidy Rivera-Urbina
Brain Sci. 2022, 12(1), 95; https://doi.org/10.3390/brainsci12010095 - 12 Jan 2022
Cited by 10 | Viewed by 9614
Abstract
Stimulation of the vagus nerve, a parasympathetic nerve that controls the neuro-digestive, vascular, and immune systems, induces pain relief, particularly in clinical conditions such as headache and rheumatoid arthritis. Transmission through vagal afferents towards the nucleus of the solitary tract (NST), the central [...] Read more.
Stimulation of the vagus nerve, a parasympathetic nerve that controls the neuro-digestive, vascular, and immune systems, induces pain relief, particularly in clinical conditions such as headache and rheumatoid arthritis. Transmission through vagal afferents towards the nucleus of the solitary tract (NST), the central relay nucleus of the vagus nerve, has been proposed as the main physiological mechanism that reduces pain intensity after vagal stimulation. Chronic pain symptoms of fibromyalgia patients might benefit from stimulation of the vagus nerve via normalization of altered autonomic and immune systems causing their respective symptoms. However, multi-session non-invasive vagal stimulation effects on fibromyalgia have not been evaluated in randomized clinical trials. We propose a parallel group, sham-controlled, randomized study to modulate the sympathetic–vagal balance and pain intensity in fibromyalgia patients by application of non-invasive transcutaneous vagus nerve stimulation (tVNS) over the vagal auricular and cervical branches. We will recruit 136 fibromyalgia patients with chronic moderate to high pain intensity. The primary outcome measure will be pain intensity, and secondary measures will be fatigue, health-related quality of life, sleep disorders, and depression. Heart rate variability and pro-inflammatory cytokine levels will be obtained as secondary physiological measures. We hypothesize that multiple tVNS sessions (five per week, for 4 weeks) will reduce pain intensity and improve quality of life as a result of normalization of the vagal control of nociception and immune–autonomic functions. Since both vagal branches project to the NST, we do not predict significantly different results between the two stimulation protocols. Full article
(This article belongs to the Special Issue Application of Transcranial Electrical Stimulation (tES) for Improving Neurocognitive and Motor Deficits)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-8
Back to TopTop