Novel therapies for Multiple Sclerosis
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurorehabilitation".
Deadline for manuscript submissions: closed (20 November 2020) | Viewed by 8943
Special Issue Editor
Interests: Neurology; Neurorehabilitation; Multiple Sclerosis; Multiple Sclerosis Treatment; Quality of Life; Cognitive impairment; Neuroepidemiology; Clinical immunology; Amyotrophic Lateral Sclerosis; NMOSD; Myastenia Gravis; Parkinson disease; Epilepsy; Patient centricity
Special Issue Information
Dear Colleagues,
There is no curative treatment available for multiple sclerosis (MS), and the current therapeutic strategy is finalized to reduce the risk of relapses and, potentially, disability progression. The field of MS therapeutics is evolving rapidly. In the last decades, new disease modifying therapies (DMTs) have been added to our armamentarium. Most DMTS are currently approved either as first line therapy or second line therapy, to treat patients with relapsing forms of MS. Fewer DMTs are approved and used to treat both primary and secondary progressive MS patients.
Beta interferons, glatiramer acetate, azathioprine, teriflunomide, dimethyl-fumarate, natalizumab, fingolimod, and alemtuzumab, as well as ocrelizumab, cladribine, siponimod, rituximab, ozanimod, ofatumumab, and autologous stem cell transplantation show different mechanisms of action that can suppress or modulate the dysregulated immune system, limiting neuroinflammation, preventing new relapses and new MRI lesions, and, finally, reducing disability worsening.
With this great variety of therapeutic options, neurologists may face new challenges selecting early more effective and personalized treatments that do not carry over a potential safety risk. Nonetheless, there is a need to thoroughly select and strictly monitor safety programs, towards a complete cessation of any disease activity. There is also a need to think of the first treatment choice for how to sequence in case of treatment failure, poor tolerability, reduced adherence, or safety concerns.
This Issue aims to provide useful guidance on personalized treatment selection based on the newest paradigms of MS management.
Prof. Dr. Francesco Patti
Guest Editor
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Keywords
- Novel therapies for Multiple Sclerosis
- Induction/Escalation
- Sequencing therapies
- Monoclonal antibodies
- Oral therapies
- Neuropathology:
- Neuroinflammation
- Neurodegeneration
- Neuroprotection
- Remyelination
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