B Cell Lymphoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 18630
Special Issue Editor
Interests: B-cell lymphoma and leukemia; addiction to the B cell proliferation and survival program; targeting of non-oncogenic addictions; Goldilocks therapy of B-cell neoplasia
Special Issue Information
Dear Colleagues,
The B-cell lymphomas are the clonal malignancies derived from mature B cells at different stages of differentiation. Although some of the B-cell lymphoma subtypes are sensitive to conventional chemotherapy and are among the most curable tumors, most of them represent a therapeutic challenge. Importantly, B-cell lymphoma survivors still suffer from acute and delayed treatment complications of aggressive chemotherapy. The introduction of the therapeutic antibodies targeting B-cell markers, followed by the appearance of immune checkpoint inhibitors, and finally CAR-T cell immunotherapy, have further improved treatment results. Unfortunately, these new modalities are not able to cure all patients, and are not free of serious side effects.
Fortunately, growing knowledge on molecular mechanisms that are instrumental in oncogenic programs of B-cell lymphoma might open new opportunities for the therapy of B cell lymphoma. B-cell lymphomas, except for classical Hodgkin lymphoma, maintain the phenotype as well as the proliferation and survival program of their normal counterparts. In the process of maturation, B cells pass through sequential differentiation stages which rely on distinct, sometimes mutually exclusive, survival programs. The specific oncogenic program of B-cell lymphoma entities arises from the corresponding physiological program by the oncogenic activation of the physiological differentiation-stage-specific pro-survival pathways and by blocking the transition to the next differentiation stage. The identification of the role of particular pathways in specific sub-types of B-cell lymphoma has permitted the rational implementation of specific inhibitors, many of which have reached or already passed clinical trials.
These include inhibitors of proliferation and survival signaling such as LYN and SYK kinases, as well as PY3K, PI3K, AKT, and mTOR inhibitors; inhibitors of anti-apoptotic proteins BCL2 and BCL2L1; drugs targeting neoplasia-related proteotoxic stress like proteasome inhibitors; and epigenetic modifiers targeting tumor-specific transcriptional programs, including demethylating agents, HDAC, and BRD inhibitors.
This Special Issue is dedicated to broad molecular aspects of B-cell lymphoma pathogenesis and treatment with a focus on the distinctive features of the oncogenic programs of B cell lymphoma subtypes including regulation of transcription, translation, cellular metabolism. We believe that discovering new lineage-specific vulnerabilities and synthetic lethalities will help improve the therapy of B-cell lymphoma.
Dr. Alexey Ushmorov
Guest Editor
Manuscript Submission Information
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Keywords
- oncogenic program of B cell lymphoma
- targeted therapy
- epigenetic therapy
- oncogenic dependency
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