Immunohistochemical Markers in Endometrial Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 37131
Special Issue Editors
Interests: gynecological oncology; endometrial cancer; intraoperative sentinel lymph node mapping
Interests: gynecological oncology; conservative treatment for well-differentiated endometrial cancer; cytoreductive surgery; nerve-sparing radical hysterectomy
Special Issue Information
Dear Colleagues,
In the early 1980s, researchers proposed to classify endometrial cancer using two broad categories: type I (predominantly endometrioid, typical of perimenopause, with positive estrogen and progesterone receptors and usually a favorable prognosis) and type II (predominantly serous, typical of advanced post menopause, with negative estrogen and progesterone receptors and with a poorer prognosis). However, this classification did not allow for a clear location of grade III endometrioid carcinoma and clear cell carcinoma. For this reason, the current morphological classification of endometrial cancer is based on the use of numerous immunohistochemical markers to try to solve doubtful cases.
Less than ten years ago, a Cancer Genome Atlas (TCGA) study revealed that endometrial cancer is a complex pathology attributable to four molecular subtypes with prognostic significance. Unfortunately, this molecular classification cannot be obtained based on biopsy tissue before the definitive hysterectomy. For this reason, various immunohistochemical markers are now being studied as indicative of the belonging of a given tumor to a specific molecular subtype. This Special Issue aims to provide an overview of the current state of the art in the use of immunohistochemical markers to reclassify endometrial cancer into homogeneous groups characterized by specific prognoses and therapeutic possibilities.
Prof. Dr. Valerio Mais
Dr. Michele Peiretti
Guest Editors
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Keywords
- endometrial cancer
- immunohistochemistry
- immunohistochemical markers
- classification
- prognosis
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