Pediatric Cancer Research from Basic Biology to Experimental Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Pediatric Oncology".
Deadline for manuscript submissions: 14 February 2025 | Viewed by 595
Special Issue Editor
2. Department of Pathology, Seattle Children's Hospitals, Seattle, WA 98105, USA
Interests: pediatric tumors; pediatric cancer biology; protein expression in cancer; proteome profiling from histologic slides; microRNA expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumors in children are different from those in adults and can range from benign, intermediate, and malignant neoplasia. The incidence of pediatric tumors varies in different racial and ethnic groups and geographic regions, reflecting their diverse biology and environmental influence. A better understanding of pediatric cancer biology and genetics is needed to reflect its heterogeneity, clinical behavior, and response to therapy. Malignant tumors have a complex biology that is characterized by rapid proliferation, a spectrum of cellular differentiation, and an association with developmental genes. The pediatric cancer genetic profile is unique, featuring a high prevalence of specific structural variations (e.g., gene fusions and chromosomal rearrangements) and predisposing germline variants. The classification of pediatric tumors has recently evolved, now incorporating novel genetically defined entities and ancillary tests that have resulted in more precise tumor definition. This unique profile translates to unique biology, morphology, microenvironment, clinical behavior, and therapy response. Traditional and novel therapeutic regimens are burdened by therapy resistance and tumor progression. Basic and translation research, genetic sequencing, and epigenetic analysis have opened new opportunities for patients to be included in clinical trials. This Special Issue aims to highlight the recent advances in pediatric tumor research, including basic biology, tumor microenvironment, novel treatment, and cellular and genetic landscapes.
In this Special Issue, original research articles and reviews are welcome that may include (but are not limited to) the following:
- Developmental biology and cancer predisposition syndromes;
- Preclinical models of pediatric cancer and translational research;
- Genetics and epigenetics of different pediatric tumors including hematopoietic malignancies, solid cancers, and tumors of intermediate malignancy;
- Biologic basis of therapy and therapy resistance;
- Molecular diagnostic, prognostic, and predictive biomarkers.
We look forward to receiving your contributions
Prof. Dr. Atif Ahmed
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pediatric tumors
- solid cancers
- leukemias
- cancer predisposition syndromes
- genetics
- omics
- immunotherapy
- therapy resistance
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