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Cancers
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The Role of Ferroptosis in Cancer
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The Role of Ferroptosis in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1588

Special Issue Editor

Dr. Wei Li

E-Mail Website
Guest Editor
Department of Pediatrics, Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, USA
Interests: hippo pathway; brain tumor; tumor microenvironment; ferroptosis; regulated cell death

Special Issue Information

Dear Colleagues,

Ferroptosis is a type of regulated cell death (RCD) that depends on iron and is caused by lethal accumulation of intracellular lipid peroxides. Since it was discovered more than a decade ago, studies have found that tumor cells, while able to resist other types of therapy-induced cell death, such as apoptosis, are sensitive to ferroptosis. These different responses led people to examine the therapeutic benefit of eliminating tumor cells through ferroptosis. Accumulating evidence has been emerging to support this notion. On the other hand, ferroptotic cells, through releasing damage-associated molecular patterns (DAMPs) or other metabolites, could alter the tumor microenvironment, especially immune cells. This effect could be associated with enhanced immunogenicity; however, in certain situations, it may lead to sustained inflammation and have an immunosuppressive impact, thereby promoting tumor progression and therapeutic resistance. How to exploit ferroptosis to benefit cancer therapy while circumventing the potential tumor promotion effect is under intense study.

This Special Issue will highlight the latest advances in basic and translational research of ferroptosis in cancer, aiming to accelerate the speed in exploiting ferroptosis for cancer treatment.

Dr. Wei Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ferroptosis
  • cancer
  • reactive oxygen species
  • ROS
  • regulated cell death
  • RCD
  • immunogenic cell death
  • ICD
  • immunosuppression

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Published Papers (2 papers)

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Research

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17 pages, 2237 KiB  
Article
GPX4 and FSP1 Expression in Lung Adenocarcinoma: Prognostic Implications and Ferroptosis-Based Therapeutic Strategies
by Hirotomo Takahara, Takumi Kanazawa, Haruna Oshita, Yoshinobu Tomita, Yuri Hananoi, Sachiko Ishibashi, Masumi Ikeda, Asuka Furukawa, Mayumi Kinoshita, Kurara Yamamoto, Yuki Kato, Hironori Ishibashi, Kenichi Okubo, Morito Kurata, Masanobu Kitagawa, Kenichi Ohashi and Kouhei Yamamoto
Cancers 2024, 16(22), 3888; https://doi.org/10.3390/cancers16223888 - 20 Nov 2024
Viewed by 255
Abstract
Background: Primary lung cancer is among the cancers with the poorest prognosis, having the highest mortality rate among men and the second highest among women in Japan. While surgery is the primary treatment, advanced stages often require pharmacotherapy. Recently, ferroptosis, an iron-dependent form [...] Read more.
Background: Primary lung cancer is among the cancers with the poorest prognosis, having the highest mortality rate among men and the second highest among women in Japan. While surgery is the primary treatment, advanced stages often require pharmacotherapy. Recently, ferroptosis, an iron-dependent form of cell death caused by lipid peroxidation, has gained attention as a potential therapeutic strategy. This study investigated the prognostic impact of lipid peroxidation marker and regulators involved in ferroptosis in lung adenocarcinoma. Methods: We analyzed 207 patients who underwent resection surgery for lung adenocarcinoma at Tokyo Medical and Dental University Hospital. Immunohistochemistry was used to evaluate the expression levels of glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), and 4-hydroxy-2-nonenal (4-HNE). The association between these markers and clinicopathological factors was assessed, and in vitro experiments were conducted to examine the effects of these markers on cell death. Results: Low cytoplasmic accumulation of 4-HNE and low expression of GPX4 were associated with a worse prognosis, and low FSP1 expression was associated with unfavorable relapse-free survival. In vitro experiments demonstrated that 4-HNE inhibited cell proliferation, and combined inhibition of GPX4 and FSP1 induced ferroptosis. Conclusions: These findings suggest that lipid peroxidation markers and regulators can serve as prognostic biomarkers and therapeutic targets in lung adenocarcinoma. Full article
(This article belongs to the Special Issue The Role of Ferroptosis in Cancer)
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Review

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19 pages, 4025 KiB  
Review
Inorganic Nanomedicine—Mediated Ferroptosis: A Synergistic Approach to Combined Cancer Therapies and Immunotherapy
by Adityanarayan Mohapatra, Ayeskanta Mohanty and In-Kyu Park
Cancers 2024, 16(18), 3210; https://doi.org/10.3390/cancers16183210 - 20 Sep 2024
Cited by 1 | Viewed by 927
Abstract
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis in tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, ferroptosis presents unique [...] Read more.
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis in tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, ferroptosis presents unique molecular and cellular features, representing a promising approach for cancers resistant to conventional treatments. Recent research indicates a strong link between ferroptosis and the tumor immune microenvironment, suggesting the potential of ferroptosis to trigger robust antitumor immune responses. Multiple cellular metabolic pathways control ferroptosis, including iron, lipid, and redox metabolism. Thus, understanding the interaction between tumor metabolism and ferroptosis is crucial for developing effective anticancer therapies. This review provides an in-depth discussion on combining inorganic nanoparticles with cancer therapies such as phototherapy, chemotherapy, radiotherapy, and immunotherapy, and the role of ferroptosis in these combination treatments. Furthermore, this paper explores the future of tumor treatment using nanomedicine, focusing on how inorganic nanoparticles can enhance ferroptosis in tumor cells and boost antitumor immunity. The goal is to advance ferroptosis-based nanomedicine from the laboratory to clinical applications. Full article
(This article belongs to the Special Issue The Role of Ferroptosis in Cancer)
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