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Cancers
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Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer
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Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 5033

Special Issue Editor

Dr. Biniam Kidane

E-Mail Website
Guest Editor
Section of Thoracic Surgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Interests: inflammatory response to intra-operative ventilation and lung surgery; inflammatory response and risk of metastasis; inflammatory mechanisms of treatment-related lung injury; health-related quality of life in esophageal cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to announce a call for submissions to this Special Issue of Cancers, titled "Clinical and Research Progress in the Resection of Gastro-Esophageal cancer". Gastro-esophageal cancers are a source of substantial global morbidity and mortality. Traditionally, non-metastatic cancers are treated with surgical resection, with a possible combination of chemotherapy and radiation therapy. These can also be sources of significant treatment-related toxicities. The resection of gastro-esophageal cancer is associated with some of the highest incidences of morbidity and mortality. The progress related to improving outcomes for patients with gastro-esophageal cancers is dependent on improving the morbidity and mortality associated with resection and surgery.

We encourage the submission of both original research articles and reviews on all aspects of the advances in resection and multi-modal management of gastro-esophageal cancer. All submitted articles will undergo peer review.

Dr. Biniam Kidane
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

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Research

13 pages, 570 KiB  
Article
Effect of Neoadjuvant Therapy on Endoluminal Vacuum-Assisted Closure Therapy (EVAC) for Anastomotic Leakage After Oesophagectomy
by Catharina Fahrenkrog, Sorin Miftode, Ahmed Al-Mawsheki, Fadl Alfarawan, Stella Wilters, Maximilian Bockhorn and Nader El-Sourani
Cancers 2024, 16(21), 3597; https://doi.org/10.3390/cancers16213597 - 25 Oct 2024
Viewed by 443
Abstract
Background: Anastomotic leakage (AL) is a dreaded complication after oesophagectomy. Endoluminal vacuum-assisted closure therapy (EVAC) has been increasingly used as a first-line treatment for AL. We aimed to identify any potential adverse effects of a neoadjuvant therapy (chemotherapy (CT) or radiochemotherapy (RCT)) on [...] Read more.
Background: Anastomotic leakage (AL) is a dreaded complication after oesophagectomy. Endoluminal vacuum-assisted closure therapy (EVAC) has been increasingly used as a first-line treatment for AL. We aimed to identify any potential adverse effects of a neoadjuvant therapy (chemotherapy (CT) or radiochemotherapy (RCT)) on EVAC. Methods: We performed a retrospective cohort study at our tertiary centre between 2013 and 2024. All patients who underwent EVAC for AL after oesophagectomy were included in this study. Parameters such as success rate, length of therapy, number of sponges needed, changes in treatment, and survival were analysed. Results: A total of 29 patients were included, 19 of whom received CT/RCT and 10 of whom received no neoadjuvant treatment (NT). There was no significant difference in patient survival (30-day survival rate CT/RCT n = 1 (5.3%) vs. NT n = 1 (10%), p = 0.632), success rate (CT/RCT n = 15 (78.9%) vs. NT n = 9 (90%), p = 0.454), and length of therapy (CT/RCT vs. NT 24.11 vs. 23.8, p = 0.681), the number of sponges required (CT/RCT vs. NT 6.26 vs. 6.6, p = 0.835), and the need for changing treatment (CT/RCT n = 5 (26.3%) vs. NT n = 1 (10%), p = 0.303). Conclusions: NT did not affect the success rate or length of therapy. Thus, we found no significant influence of CT/RCT on EVAC for AL after oesophagectomy. Full article
(This article belongs to the Special Issue Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer)
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9 pages, 862 KiB  
Article
Comparison of Short-Term Outcomes after Robotic Surgery for Gastric Cancer in Elderly and Younger Patients: A Retrospective Cohort Study
by Laura Fortuna, Fabio Staderini, Francesco Coratti and Fabio Cianchi
Cancers 2024, 16(16), 2849; https://doi.org/10.3390/cancers16162849 - 15 Aug 2024
Viewed by 564
Abstract
Robot-assisted surgery has recently been introduced to overcome some drawbacks and technical limitations in performing laparoscopic gastrectomy. The aim of the present study was to evaluate the feasibility and safety of robotic gastrectomy in elderly patients. The study enrolled 143 patients who underwent [...] Read more.
Robot-assisted surgery has recently been introduced to overcome some drawbacks and technical limitations in performing laparoscopic gastrectomy. The aim of the present study was to evaluate the feasibility and safety of robotic gastrectomy in elderly patients. The study enrolled 143 patients who underwent robotic gastrectomy in a single high-volume centre. All patients were divided into two groups based on age: elderly group ≥ 75 years old (EG; n = 64) and non-elderly group < 75 years old (NEG; n = 79). Comorbidities were significantly more frequent in the EG (95.3%) than in the NEG (81%) (p = 0.011). Similarly, the percentage of ASA 3 patients was significantly higher in the EG than in the NEG (43.8% vs. 24.0%, respectively; p = 0.048). Nevertheless, the incidence of Clavien–Dindo grade III and IV complications did not differ significantly between the two groups (10.9% in the EG and 6.3% in the NEG; p = 0.852). Moreover, operative time, re-operation rate, mean number of harvested lymph nodes, 30-day mortality, and median hospital stay were similar within the two groups. Our study suggests that robotic gastrectomy can be performed safely for elderly patients. In particular, chronological age does not seem to affect either the clinical or oncological short-term outcomes after robotic gastrectomy. Full article
(This article belongs to the Special Issue Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer)
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11 pages, 1181 KiB  
Article
Impact of Neoadjuvant Treatment on Body Composition in Patients with Locally Advanced Gastric Cancer
by Luz Divina Juez, Pablo Priego, Marta Cuadrado, Luis A. Blázquez, Silvia Sánchez-Picot, Pablo Gil, Federico Longo, Julio Galindo, José María Fernández-Cebrián and José I. Botella-Carretero
Cancers 2024, 16(13), 2408; https://doi.org/10.3390/cancers16132408 - 29 Jun 2024
Viewed by 1131
Abstract
Neoadjuvant chemotherapy (NT) followed by radical surgery is the standard treatment for locally advanced gastric cancer (GC). The incidence of sarcopenia in upper gastrointestinal tract malignancies is very high, and it may be increased after NT. This study aimed to evaluate the impact [...] Read more.
Neoadjuvant chemotherapy (NT) followed by radical surgery is the standard treatment for locally advanced gastric cancer (GC). The incidence of sarcopenia in upper gastrointestinal tract malignancies is very high, and it may be increased after NT. This study aimed to evaluate the impact of NT on body composition. A retrospective study of patients with locally advanced GC undergoing gastrectomy who had received NT in a tertiary hospital between 2012 and 2019 was conducted. CT measured the skeletal muscle index, total psoas area, and visceral and subcutaneous adipose tissue before and after NT. Of the 180 gastrectomies for GC, 61 patients received NT. During NT, changes in body composition were observed with a decrease in the skeletal muscle mass index (SMMI −2.5%; p < 0.001), and these changes were significantly greater in men (SMMI −10.55%). Before surgery, patients who received NT presented 15% more sarcopenia than those without NT (p = 0.048). In conclusion, patients with locally advanced gastric cancer who receive NT have significant changes in body composition during chemotherapy. These changes, which are at the expense of a loss of muscle mass, lead to an increased incidence of pre-surgical sarcopenia. Full article
(This article belongs to the Special Issue Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer)
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16 pages, 2362 KiB  
Article
Early Gastric Cancers in Central Norway 2001 to 2016—A Population-Based Study
by Camilla J. Kvamme, Thomas L. Stillingen, Alina D. Sandø, Patricia Mjønes, Erling A. Bringeland and Reidar Fossmark
Cancers 2024, 16(6), 1222; https://doi.org/10.3390/cancers16061222 - 20 Mar 2024
Viewed by 1032
Abstract
Early gastric cancers (EGCs) are confined to the gastric mucosa and submucosa irrespective of lymph node metastases and constitute only a minor proportion of gastric cancer in Western countries. We aimed to characterize EGCs and assess the survival of EGC in Central Norway [...] Read more.
Early gastric cancers (EGCs) are confined to the gastric mucosa and submucosa irrespective of lymph node metastases and constitute only a minor proportion of gastric cancer in Western countries. We aimed to characterize EGCs and assess the survival of EGC in Central Norway during 2001–2016. A retrospective population-based study on 1205 patients with gastric cancer was performed. At the time, surgical resection was the standard treatment, and 88 (7.3%) EGCs were identified. Histopathological specimens were re-examined, and the eCura score and survival were evaluated. The number of gastric cancers declined (p = 0.010), but the relative proportion of EGC was unchanged during the study period. EGCs were more often of the Lauren intestinal type (p < 0.001) compared with controls. A significant proportion (9.4%, n = 5) of the patients with a low-risk eCura had lymph node metastases, whereas further exclusion of tumors with histological ulceration or SM2 invasion identified an N0 cohort. The median survival for EGC patients was 117.1 months (95% CI 99.8–134.3) and the 5-year overall survival was 75%. Twelve deaths were cancer-related, either due to postoperative complications (5.7%, n = 5) or cancer recurrence (8%, n = 7). In conclusion, EGCs constituted a minor but constant proportion of gastric cancers. eCura alone was insufficient in predicting patients with pN0 disease. Full article
(This article belongs to the Special Issue Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer)
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14 pages, 272 KiB  
Article
Rural Women Have a Prolonged Recovery Process after Esophagectomy
by Julia Schroeder, Kiran Lagisetty, William Lynch, Jules Lin, Andrew C. Chang and Rishindra M. Reddy
Cancers 2024, 16(6), 1078; https://doi.org/10.3390/cancers16061078 - 7 Mar 2024
Viewed by 1377
Abstract
Background: Gender and geographic access to care play a large role in health disparities in esophageal cancer care. The aim of our study was to evaluate disparities in peri-operative outcomes for patients undergoing esophagectomy based on gender and geographic location. Methods: A retrospective [...] Read more.
Background: Gender and geographic access to care play a large role in health disparities in esophageal cancer care. The aim of our study was to evaluate disparities in peri-operative outcomes for patients undergoing esophagectomy based on gender and geographic location. Methods: A retrospective cohort of prospectively collected data from patients who underwent esophagectomy from 2003 to 2022 was identified and analyzed based on gender and county, which were aggregated into existing state-level “metropolitan” versus “rural” designations. The demographics, pre-operative treatment, surgical complications, post-operative outcomes, and length of stay (LOS) of each group were analyzed using chi-squared, paired t-tests and single-factor ANOVA. Results: Of the 1545 patients, men (83.6%) and women (16.4%) experienced similar rates of post-operative complications, but women experienced significantly longer hospital (p = 0.002) and ICU (p = 0.03) LOSs as compared with their male counterparts, with no differences in 30-day mortality. When separated by geographic criteria, rural women were further outliers, with significantly longer hospital LOSs (p < 0.001) and higher rates of ICU admission (p < 0.001). Conclusions: Rural female patients undergoing esophagectomy were more likely to have a longer inpatient recovery process compared with their female metropolitan or male counterparts, suggesting a need for more targeted interventions in this population. Full article
(This article belongs to the Special Issue Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer)
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