The Improvement of Biocatalysis: Enzyme and Reaction Medium Modification
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".
Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 3324
Special Issue Editors
Interests: metalloenzymes; catalytic mechanisms; enzymes from anaerobic metabolic pathways; modelling enzymatic reactions; reaction engineering
Special Issues, Collections and Topics in MDPI journals
Interests: food enzymes; biocatalysis; medium engineering; food compounds modification; enzyme inhibition; lignocellulose hydrolysis; fermentation
Special Issues, Collections and Topics in MDPI journals
Interests: enzymatic modification of food ingredients; food enzymes; reaction environmental engineering; enzymes in reduction of food immunoreactivity; fermentation
Special Issue Information
Dear Colleagues,
Chemical reactions catalyzed by enzymes are important because of the rate and stereospecificity of transformation. Biocatalysts are a greener alternative to traditional synthesis that offers a tool for the transformation under mild reaction conditions, low energy requirements and minimizing the problems of isomerization and rearrangement. However, the application of enzymes is often limited because of the harsh reaction medium conditions, and the use of non-conventional solvents. In recent decades, a new paradigm of biocatalysis was presented to overcome enzyme deactivation or a dramatic drop in catalytic activity. The new paradigm required modification and matching of enzyme properties to bioprocess requirements. The target is the development of tailor-made biocatalysts suitable for industrial applications. Detailed molecular understanding of the protein structure and conformational dynamics allows us to tune catalytic activity by modifying the solvent, the support, or the active site of the enzyme. Immobilization represents a promising and straightforward route to obtaining high activity and stability of enzymes. Along with physicochemical methods of enzyme stabilization, such as additive approach, chemical modification, also protein engineering and high-throughput screening can be used to enhance the performance of biocatalysts. It is quite important to obtain mutant libraries designed according to a “small but smart” concept.
This Special Issue aims to contribute to the current knowledge in the field of biocatalysis, e.g., in pharmacy, food industry and environmental application. Articles focusing on the improvement of the efficiency of biocatalysts and enzymatic processes, bioinformatics, and protein engineering are welcomed. In this Special Issue, we invite the submission of original research articles and reviews.
We look forward to your contributions.
Prof. Dr. Maciej Szaleniec
Dr. Marek Adamczak
Dr. Bartosz Brzozowski
Guest Editors
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Keywords
- biocatalysis
- biotransformation
- enzyme modification
- protein engineering
- medium engineering
- non-conventional media
- enzyme immobilization
- directed evolution
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