Programmed Cell Death and Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 3237
Special Issue Editor
Interests: neurodegeneration; Inflammation; brain organoids; ESCs; iPSC
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many neurodegenerative diseases are characterized by the progressive deterioration of neuronal function caused by the degeneration of synapses, axons and ultimately the death of nerve cells. An increased understanding of the molecular pathways of programmed cell death (PCD) underlying altered cellular homeostasis and neurodegeneration is critical to the development of effective treatments for disease.
In recent decades, studies have elucidated several key cell death signaling pathways as well as their possible consequences. However, in neurodegenerative diseases, the immune system also plays a critical role. Therefore, future cell death studies need to analyze cell death machinery and explore the physiological response of the immune system to each cell death mechanism in order to develop new therapeutic approaches.
This Special Issue will present cutting-edge views on the mechanisms that determine those effects and consequences of programmed cell death in the surrounding microenvironment of many neurodegenerative diseases. Additionally, this Special Issue will cover promising, recent and novel research trends exploring the relationship of cell death mechanisms and surrounding cell responses. Original research, reviews and mini-reviews are welcome.
The topics will include, but are not limited to:
- Discoveries in novel cell death modes.
- Mechanisms that determine the physiological impact of dead cells.
- The role of cell death in physiological and pathological processes, such as Alzheimer’s disease, Parkinson’s disease, ALS, HD, etc.
- Mechanisms that determine the physiological impact of dead cells.
- Therapeutic implications of cell death regulation.
- The non-killing function of cell death machinery.
- New approaches to prevent cell death in neurodegenerative diseases.
Dr. Ana Sevilla
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegeneration
- cell death
- neuroinflammation
- apoptotic pathways
- neuronal loss
- Parkinson’s disease
- Alzheimer’s disease
- Huntington disease
- ALS
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