100th Anniversary of Nobel Prize in Physiology or Medicine 1922: Metabolism in Muscle

Dear Colleagues,

The 1922 Nobel Prize in Physiology or Medicine was divided equally between Archibald Vivian Hill "for his discovery of heat generation in muscle" and Otto Fritz Meyerhof "for his discovery of the fixed relationship between oxygen consumption and lactic acid metabolism in muscle."

Both scientists’ research was concerned with muscle tissue.

Archibald Vivian Hill discovered that in order to work, our muscles need energy, which is released by chemical processes. He had been studying this process since the 1910s. He discovered that energy comes from a sequence of chemical processes, the first being independent of oxygen consumption and the second requiring oxygen.

Otto Fritz Meyerhof discovered that the conversions between carbohydrates and lactic acid play an important role in producing the energy that muscle needs to work. He demonstrated that lactic acid is produced from carbohydrates during muscle work and that lactic acid is burned and recycled from carbohydrates during recovery.

The discoveries of these two scientists, who were awarded the Nobel Prize in Medicine and Physiology, are a milestone in the study of skeletal muscle metabolism. A hundred years after their discovery, much more new information has been added to the ideas of these two scientists.

These 100 years have also seen the discovery of many similarities between skeletal muscle and cardiac muscle, the two striated muscle tissues of our body.

The new discoveries about satellite cells or progenitor cells of both cardiac muscle and skeletal muscle are certainly very important. New genetic or cellular therapies have been discovered to improve cardiac health or to improve the clinical condition of many patients with muscular dystrophy.

However, new discoveries are still needed because many muscle diseases, such as Duchenne dystrophy, still affect many people with no real cure, only palliative remedies.

This Special Issue aims to collect new discoveries that may lead to new advances in the field of muscle diseases in general, both skeletal and cardiac.

Dr. Valentina Di Felice
Guest Editor

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• exercise training
• striated muscle
• muscle regeneration
• muscular dystrophy
• muscle wasting
• muscle metabolism