Neuroprotection in Ischemic Stroke: From Mechanisms to Therapeutics
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1712
Special Issue Editors
Interests: the link among neural plasticity, brain circuits and behavior, focusing on associative and non-associative learning in mice; neuromodulatory properties of the non-invasive brain stimulation (NIBS) techniques tDCS and rTMS in physiological and pathological conditions in mice, focusing on neural plasticity and cortical/subcortical functional networks
Interests: neuromodulation and neurorehabilitation for stroke, bio-signal processing; neuromusculoskeletal modeling
2. Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Interests: behavioral neuroscience; molecular and cellular neuroscience; neural plasticity and excitability; non-invasive brain stimulation techniques; stroke; dementia
Special Issue Information
Dear Colleagues,
Ischemic stroke is known to result in a significant loss of specific functions, mostly motor, with almost two thirds of survivors leaving the hospital with a disability. However, due to different neural and non-neural cell mechanisms (e.g. neural plasticity, glial or endothelial response), some functional aspects can be recovered. Notably, increasing evidence suggests that it is possible to effectively intervene at different timeframes with several tools, ranging from mechanical intervention to drugs, from physiotherapy to non-invasive neuromodulation. During the acute phase, a multifactorial pathological process and the causes and effects of cell death/suffering are among the main aspects to consider, while at chronic stages, interventions based on cell/network plasticity or activity modulation are mainly required.
The purpose of this Special Issue is to collect original data and reviews that focus on the mechanisms underlying neuroprotection and the recovery of brain damage in ischemic stroke, in both animal models and patients. Our hope is that contributions will give rise to a compendium, which will help to advance the knowledge of repair mechanisms and therapeutic and/or rehabilitative interventions across multiple continua to promote recovery after strokes.
Dr. Marco Cambiaghi
Dr. Le Li
Dr. Maria Vittoria Podda
Guest Editors
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Keywords
- neural plasticity
- neuromodulation
- penumbra
- quality of life
- acute
- chronic
- excitotoxicity
- molecular targets
- clinical trials
- safety
- animal models
- combination
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