Cell-to-Cell Crosstalk as a Target of Therapies

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 May 2025 | Viewed by 577

Special Issue Editors


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Guest Editor
Department of Molecular Physiology and Neurobiology, University of Wroclaw, ul. Sienkiewicza 21, 50-335 Wroclaw, Poland
Interests: multifunctional proteins; subcellular organization of energy metabolism; cell-to-cell crosstalk
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Molecular Physiology and Neurobiology, University of Wroclaw, Sienkiewicza 21, 50-335 Wroclaw, Poland
Interests: astrocyte-neuron crosstalk; aging; energy metabolism; brain plasticity and memory formation; proteomics; metabolomics; behavioral tests; electrophysiology; enzymology; protein-protein interaction; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In a multicellular organism, no cell is an isolated island. In an organ, tissue and the entire body, cells of different types and origins communicate with each other, sometimes over long distances, creating a healthy physiological environment. This complex set of interactions among cells is referred to as cell-to-cell crosstalk. It occurs through various mechanisms (e.g., paracrine signaling, extracellular vesicles, membrane nanotubes, and "classical" physical contacts between neighboring cells) and mediators (e.g., proteins, microRNA, and metabolites). The aim of this Special Issue is to disseminate and summarize the latest developments in our understanding of cell-to-cell crosstalk and its role in pathogenesis, and how our knowledge of this phenomenon can be used to create new therapies. We welcome original and review articles covering any aspects of this topic.

Dr. Agnieszka Gizak
Dr. Dominika Drulis-Fajdasz
Guest Editors

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Keywords

  • cell-to-cell crosstalk
  • cellular communication
  • microenvironment
  • extracellular vesicles
  • diagnostic tools
  • membrane nanotubes
  • pathogenesis
  • therapy
  • cell metabolism
  • homeostasis

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Published Papers (1 paper)

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Review

42 pages, 2107 KiB  
Review
Impact of Physical Activity on Cellular Metabolism Across Both Neurodegenerative and General Neurological Conditions: A Narrative Review
by Vicente Javier Clemente-Suárez, Alejandro Rubio-Zarapuz, Pedro Belinchón-deMiguel, Ana Isabel Beltrán-Velasco, Alexandra Martín-Rodríguez and José Francisco Tornero-Aguilera
Cells 2024, 13(23), 1940; https://doi.org/10.3390/cells13231940 - 22 Nov 2024
Abstract
Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Objective: The objective of this review is to evaluate the molecular mechanisms by which exercise influences cellular [...] Read more.
Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Objective: The objective of this review is to evaluate the molecular mechanisms by which exercise influences cellular metabolism, with a focus on its potential as a therapeutic intervention for neurological disorders. Methods: A comprehensive literature review was conducted using peer-reviewed scientific articles, with a focus on the period between 2015 and 2024, to analyze the effects of exercise on mitochondrial function, oxidative stress, and metabolic health. Results: The findings indicate that exercise promotes mitochondrial biogenesis, enhances oxidative phosphorylation, and reduces reactive oxygen species, contributing to improved energy production and cellular resilience. These metabolic adaptations are associated with delayed disease progression and reduced symptoms in patients with neurodegenerative conditions. Additionally, integrating exercise with nutritional strategies may further enhance therapeutic outcomes by addressing metabolic disturbances comprehensively. Conclusion: This review concludes that personalized exercise protocols should be developed to optimize metabolic benefits for patients with neurological diseases, while future research should focus on biomarker development for individualized treatment approaches. These findings highlight the importance of non-pharmacological interventions in managing neurodegenerative diseases. Full article
(This article belongs to the Special Issue Cell-to-Cell Crosstalk as a Target of Therapies)
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